Expression of heat shock protein (Hsp) 70 and Hsp 40 in gastric cancer

Hajime Isomoto, Mikio Oka, Yoshitsugu Yano, Yusei Kanazawa, Hiroshi Soda, Ryusuke Terada, Toru Yasutake, Toshiyuki Nakayama, Saburo Shikuwa, Fuminao Takeshima, Heiichiro Udono, Ikuo Murata, Kenzo Ohtsuka, Shigeru Kohno

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70 Citations (Scopus)

Abstract

Heat shock proteins (Hsp) 70 and Hsp 40 are stress proteins that cooperate as chaperones in mammalian cells. We determined the expression of Hsp 70 and Hsp 40 in 81 gastric cancers. Immunoreactivities to Hsp 70 and Hsp 40 were detected in 67.9 and 22.2% of tumors, respectively. Immunohistochemical analysis showed enhanced Hsp 70 and Hsp 40 expression in gastric tumor tissue, relative to the surrounding normal tissue. Overexpression of Hsp 70 and Hsp 40 was also confirmed by immunoblotting. Among various clinicopathological parameters, low histopathological differentiation was associated with reduced expression of both proteins.

Original languageEnglish
Pages (from-to)219-228
Number of pages10
JournalCancer Letters
Volume198
Issue number2
DOIs
Publication statusPublished - Aug 2003
Externally publishedYes

Keywords

  • Gastric cancer
  • Heat shock protein 40
  • Heat shock protein 70
  • Immunoblot
  • Immunohistochemistry

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Isomoto, H., Oka, M., Yano, Y., Kanazawa, Y., Soda, H., Terada, R., Yasutake, T., Nakayama, T., Shikuwa, S., Takeshima, F., Udono, H., Murata, I., Ohtsuka, K., & Kohno, S. (2003). Expression of heat shock protein (Hsp) 70 and Hsp 40 in gastric cancer. Cancer Letters, 198(2), 219-228. https://doi.org/10.1016/S0304-3835(03)00305-7