Expression of H-related antigen on human megakaryocytes and megakaryocytic leukemic cells

M. Okumura, Y. Morishima, M. Ogura, Y. Morishita, M. Tanimoto, R. Ohno, H. Saito

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A mouse monoclonal antibody (MoAb), MG-2, was produced by immunizing a characterized human megakaryoblastic cell line, MEG-01. Since MG-2 reacted with erythrocytes of all ABH blood groups except O(h) (O Bombay), and since anti-H MoAb inhibited MG-2 binding to MEG-01 cells, MG-2 is considered to recognize a molecule closely related to blood group antigen H. MG-2 reacted more strongly with normal smaller sized megakaryocytes than with larger sized ones, and not with platelets. The expression of the intrinsic H-related antigen on MEG-01 cells decreased concomitant to megakaryocytic differentiation induced by phorbol esters. This H-related antigen was expressed on leukemia cells with the megakaryocytic features from blast crisis of chronic myelogenous leukemia and acute megakaryoblastic leukemia.

Original languageEnglish
Pages (from-to)151-158
Number of pages8
JournalInternational Journal of Hematology
Volume54
Issue number2
Publication statusPublished - 1991
Externally publishedYes

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Megakaryocytes
Leukemia, Megakaryoblastic, Acute
Monoclonal Antibodies
ABO Blood-Group System
Blast Crisis
Phorbol Esters
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Blood Group Antigens
Leukemia
Blood Platelets
Erythrocytes
Cell Line
H antigen

ASJC Scopus subject areas

  • Hematology

Cite this

Okumura, M., Morishima, Y., Ogura, M., Morishita, Y., Tanimoto, M., Ohno, R., & Saito, H. (1991). Expression of H-related antigen on human megakaryocytes and megakaryocytic leukemic cells. International Journal of Hematology, 54(2), 151-158.

Expression of H-related antigen on human megakaryocytes and megakaryocytic leukemic cells. / Okumura, M.; Morishima, Y.; Ogura, M.; Morishita, Y.; Tanimoto, M.; Ohno, R.; Saito, H.

In: International Journal of Hematology, Vol. 54, No. 2, 1991, p. 151-158.

Research output: Contribution to journalArticle

Okumura, M, Morishima, Y, Ogura, M, Morishita, Y, Tanimoto, M, Ohno, R & Saito, H 1991, 'Expression of H-related antigen on human megakaryocytes and megakaryocytic leukemic cells', International Journal of Hematology, vol. 54, no. 2, pp. 151-158.
Okumura M, Morishima Y, Ogura M, Morishita Y, Tanimoto M, Ohno R et al. Expression of H-related antigen on human megakaryocytes and megakaryocytic leukemic cells. International Journal of Hematology. 1991;54(2):151-158.
Okumura, M. ; Morishima, Y. ; Ogura, M. ; Morishita, Y. ; Tanimoto, M. ; Ohno, R. ; Saito, H. / Expression of H-related antigen on human megakaryocytes and megakaryocytic leukemic cells. In: International Journal of Hematology. 1991 ; Vol. 54, No. 2. pp. 151-158.
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