Expression of H-related antigen on human megakaryocytes and megakaryocytic leukemic cells

M. Okumura, Y. Morishima, M. Ogura, Y. Morishita, M. Tanimoto, R. Ohno, H. Saito

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Abstract

A mouse monoclonal antibody (MoAb), MG-2, was produced by immunizing a characterized human megakaryoblastic cell line, MEG-01. Since MG-2 reacted with erythrocytes of all ABH blood groups except O(h) (O Bombay), and since anti-H MoAb inhibited MG-2 binding to MEG-01 cells, MG-2 is considered to recognize a molecule closely related to blood group antigen H. MG-2 reacted more strongly with normal smaller sized megakaryocytes than with larger sized ones, and not with platelets. The expression of the intrinsic H-related antigen on MEG-01 cells decreased concomitant to megakaryocytic differentiation induced by phorbol esters. This H-related antigen was expressed on leukemia cells with the megakaryocytic features from blast crisis of chronic myelogenous leukemia and acute megakaryoblastic leukemia.

Original languageEnglish
Pages (from-to)151-158
Number of pages8
JournalInternational journal of hematology
Volume54
Issue number2
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Hematology

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    Okumura, M., Morishima, Y., Ogura, M., Morishita, Y., Tanimoto, M., Ohno, R., & Saito, H. (1991). Expression of H-related antigen on human megakaryocytes and megakaryocytic leukemic cells. International journal of hematology, 54(2), 151-158.