Expression of glucocorticoid receptor α and its regulation in the bovine endometrium: Possible role in cyclic prostaglandin F2α production

Mariko Kuse, Hwa Yong Lee, Tomas J. Acosta, Takuo Hojo, Kiyoshi Okuda

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Cortisol (Cr), the most important glucocorticoid (GC), is well known to suppress uterine prostaglandin F2α (PGF) production. However, the details of the regulatory mechanisms controlling the cyclic changes in endometrial PGF production remain unclear. Here we investigated the expression of the GC receptor (GC-Rα), the actions of cortisol throughout the estrous cycle and the regulatory mechanism of GC-Rα in the bovine endometrium. The levels of GC-Rα protein were greater at the mid-luteal stage (Days 8-12) than at the other stages. Cr more strongly suppressed PGF production at the mid-luteal stage than at the follicular stage. GC-Rα expression was increased by progesterone (P4) but decreased by estradiol-17β (E2) in cultured endometrial stromal cells. The overall results suggest that ovarian steroid hormones control the cyclic changes in endometrial PGF production by regulating GC-Rα expression in bovine endometrial stromal cells.

Original languageEnglish
Pages (from-to)346-352
Number of pages7
JournalJournal of Reproduction and Development
Volume59
Issue number4
DOIs
Publication statusPublished - Aug 27 2013

Keywords

  • Cattle
  • Endometrium
  • GC-Rα
  • Prostaglandins
  • Steroids

ASJC Scopus subject areas

  • Animal Science and Zoology

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