Expression of Fibroblast growth factor 19 (Fgf19) during chicken embryogenesis and eye development, compared with Fgf15 expression in the mouse

Hitomi Kurose, Takaaki Bito, Taro Adachi, Miyuki Shimizu, Sumihare Noji, Hideyo Ohuchi

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

The normal development of eyes relies on proper signaling through Fibroblast growth factor (FGF) receptors, but the source and identity of cognate ligands have remained largely unknown. We have found that Fgf19 is expressed in the developing chicken retina. In situ hybridization discloses dynamic expression patterns for Fgf19 in the optic vesicle, lens primordia and retinal horizontal cells. Overall expression pattern of Fgf19 during chicken embryogenesis was also examined: Fgf19 is expressed in the regions associated with cranial placodes induction, boundary regions of rhombomeres, somites, specific groups of neural cells in midbrain, hindbrain, and those derived from epibranchial placodes, and the apical ectodermal ridge of limb buds. Expression pattern of the Fgf19 -orthologous gene Fgf15 was further examined in the mouse developing eye. Fgf15 is expressed in the optic vesicle, a subset of progenitor cells of neural retina, and emerging ganglion and amacrine cells during retinogenesis.

Original languageEnglish
Pages (from-to)687-693
Number of pages7
JournalGene Expression Patterns
Volume4
Issue number6
DOIs
Publication statusPublished - Oct 2004
Externally publishedYes

Fingerprint

Fibroblast Growth Factors
Embryonic Development
Chickens
Retina
Retinal Horizontal Cells
Limb Buds
Amacrine Cells
Fibroblast Growth Factor Receptors
Somites
Rhombencephalon
Mesencephalon
Ganglia
Lenses
In Situ Hybridization
Stem Cells
Ligands
Genes

Keywords

  • Chicken
  • Cranial placodes
  • Embryogenesis
  • Eye development
  • FGF15
  • FGF19
  • Fibroblast growth factor
  • Lens
  • Mouse
  • Retina
  • Retinal horizontal cell

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience

Cite this

Expression of Fibroblast growth factor 19 (Fgf19) during chicken embryogenesis and eye development, compared with Fgf15 expression in the mouse. / Kurose, Hitomi; Bito, Takaaki; Adachi, Taro; Shimizu, Miyuki; Noji, Sumihare; Ohuchi, Hideyo.

In: Gene Expression Patterns, Vol. 4, No. 6, 10.2004, p. 687-693.

Research output: Contribution to journalArticle

Kurose, Hitomi ; Bito, Takaaki ; Adachi, Taro ; Shimizu, Miyuki ; Noji, Sumihare ; Ohuchi, Hideyo. / Expression of Fibroblast growth factor 19 (Fgf19) during chicken embryogenesis and eye development, compared with Fgf15 expression in the mouse. In: Gene Expression Patterns. 2004 ; Vol. 4, No. 6. pp. 687-693.
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