Expression of cys-cys chemokine ligand 21 on human gingival lymphatic vessels

Shin Ichiro Kuroshima, Yoshihiko Sawa, Yuji Yamaoka, Kenji Notani, Shigemitsu Yoshida, Nobuo Inoue

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The cys-cys (C-C) chemokine ligand 21 is a member of the C-C chemokines that constitute a group of heparin-binding cytokines with a pattern of four or six conserved cysteines. The CCL21 is known to be expressed in secondary lymphoid tissues, however it has rarely been reported for the expression on peripheral lymphatic vessels in somatic tissue. Here we investigated the expression of CCL21 on lymphatic vessels identified by anti-desmoplakin in uninflamed and inflamed human gingiva. In uninflamed tissue the expression of CCL21 was detected on lymphatic vessels in gingiva. In uninflamed gingiva the expression of CCL21 was detected on all lymphatic capillaries of the mucosal connective tissue papillae. There were two types of collecting lymphatic vessels in the lamina propria mucosae expressing CCL21 strongly or very weakly. In inflamed gingiva no expression of CCL21 was detected on lymphatic vessels. In all tissue sections no blood vessels expressing CCL21 were observed. These results may suggest that the expression of CCL21 is predominantly induced in the peripheral lymphatic endothelium of the uninflamed mucosal microcirculation, and that under inflamed conditions a reduction of CCL21 occurs in lymphatic endothelium.

Original languageEnglish
Pages (from-to)121-127
Number of pages7
JournalTissue and Cell
Volume36
Issue number2
DOIs
Publication statusPublished - 2004
Externally publishedYes

Fingerprint

cysteinylcysteine
Lymphatic Vessels
Chemokines
Gingiva
Ligands
Lymphatic Endothelium
Mucous Membrane
Desmoplakins
Lymphoid Tissue
Microcirculation
Connective Tissue
Cysteine
Blood Vessels
Heparin
Cytokines

Keywords

  • CCL21
  • Desmoplakin
  • Human gingiva
  • Lymphatic endothelium

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Kuroshima, S. I., Sawa, Y., Yamaoka, Y., Notani, K., Yoshida, S., & Inoue, N. (2004). Expression of cys-cys chemokine ligand 21 on human gingival lymphatic vessels. Tissue and Cell, 36(2), 121-127. https://doi.org/10.1016/j.tice.2003.10.004

Expression of cys-cys chemokine ligand 21 on human gingival lymphatic vessels. / Kuroshima, Shin Ichiro; Sawa, Yoshihiko; Yamaoka, Yuji; Notani, Kenji; Yoshida, Shigemitsu; Inoue, Nobuo.

In: Tissue and Cell, Vol. 36, No. 2, 2004, p. 121-127.

Research output: Contribution to journalArticle

Kuroshima, SI, Sawa, Y, Yamaoka, Y, Notani, K, Yoshida, S & Inoue, N 2004, 'Expression of cys-cys chemokine ligand 21 on human gingival lymphatic vessels', Tissue and Cell, vol. 36, no. 2, pp. 121-127. https://doi.org/10.1016/j.tice.2003.10.004
Kuroshima, Shin Ichiro ; Sawa, Yoshihiko ; Yamaoka, Yuji ; Notani, Kenji ; Yoshida, Shigemitsu ; Inoue, Nobuo. / Expression of cys-cys chemokine ligand 21 on human gingival lymphatic vessels. In: Tissue and Cell. 2004 ; Vol. 36, No. 2. pp. 121-127.
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