Expression of cutaneous lymphocyte antigen is associated with a poor outcome of nasal-type natural killer-cell lymphoma

Tadashi Yoshino, Shigeo Nakamura, Junji Suzumiya, Nozomi Niitsu, Koichi Ohshima, Junjiro Tsuchiyama, Katsuji Shinagawa, Mitsune Tanimoto, Yoshito Sadahira, Mine Harada, Masahiro Kikuchi, Tadaatsu Akagi

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Nasal and nasal-type natural killer (NK) lymphoma is a distinct clinicopathological entity mostly associated with Epstein-Barr virus. Cases that have widespread lesions are resistant to ordinary anti-cancer therapy and take a highly aggressive course. To date, there are no available data on the relationships between the localization, clinical outcome and expression of adhesion molecules in such cases. We examined the expression of cutaneous lymphocyte antigen (CLA) in 52 cases of NK-cell lymphoma. CLA was highly expressed in cutaneous cases. Also, the CLA+ group (n = 29) had a much worse prognosis than the CLA- group (n = 23), regardless of the primary site or clinical staging. Univariate analysis identified some significant prognostic factors, and multivariate analysis of these factors showed that the expression of CLA was an independent prognostic indicator. In conclusion, the present findings established that CLA is an independent and important prognostic factor in patients with NK-cell lymphomas.

Original languageEnglish
Pages (from-to)482-487
Number of pages6
JournalBritish Journal of Haematology
Volume118
Issue number2
DOIs
Publication statusPublished - 2002

Fingerprint

Nose
Natural Killer Cells
Lymphoma
Lymphocytes
Antigens
Skin
Human Herpesvirus 4
Statistical Factor Analysis
Multivariate Analysis
Neoplasms

Keywords

  • Adhesion molecule
  • Cutaneous lymphocyte antigen
  • Nasal-type lymphoma
  • NK lymphoma
  • Prognostic factor

ASJC Scopus subject areas

  • Hematology

Cite this

Expression of cutaneous lymphocyte antigen is associated with a poor outcome of nasal-type natural killer-cell lymphoma. / Yoshino, Tadashi; Nakamura, Shigeo; Suzumiya, Junji; Niitsu, Nozomi; Ohshima, Koichi; Tsuchiyama, Junjiro; Shinagawa, Katsuji; Tanimoto, Mitsune; Sadahira, Yoshito; Harada, Mine; Kikuchi, Masahiro; Akagi, Tadaatsu.

In: British Journal of Haematology, Vol. 118, No. 2, 2002, p. 482-487.

Research output: Contribution to journalArticle

Yoshino, T, Nakamura, S, Suzumiya, J, Niitsu, N, Ohshima, K, Tsuchiyama, J, Shinagawa, K, Tanimoto, M, Sadahira, Y, Harada, M, Kikuchi, M & Akagi, T 2002, 'Expression of cutaneous lymphocyte antigen is associated with a poor outcome of nasal-type natural killer-cell lymphoma', British Journal of Haematology, vol. 118, no. 2, pp. 482-487. https://doi.org/10.1046/j.1365-2141.2002.03607.x
Yoshino, Tadashi ; Nakamura, Shigeo ; Suzumiya, Junji ; Niitsu, Nozomi ; Ohshima, Koichi ; Tsuchiyama, Junjiro ; Shinagawa, Katsuji ; Tanimoto, Mitsune ; Sadahira, Yoshito ; Harada, Mine ; Kikuchi, Masahiro ; Akagi, Tadaatsu. / Expression of cutaneous lymphocyte antigen is associated with a poor outcome of nasal-type natural killer-cell lymphoma. In: British Journal of Haematology. 2002 ; Vol. 118, No. 2. pp. 482-487.
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AU - Shinagawa, Katsuji

AU - Tanimoto, Mitsune

AU - Sadahira, Yoshito

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AU - Akagi, Tadaatsu

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