Expression of Collagen IV a1 to a6 Chains in Basement Membranes of Odontogenic Tumors

Hitoshi Nagatsuka, Eiki Fujii, Ryo Tamamura, Naoki Katase, Noriyuki Nagai, Chong Huat Siar, Yasushi Morimoto

Research output: Contribution to journalArticle

Abstract

Type IV collagen, the major component of basement membrane (BM), demonstrates a stage- and position-specific distribution of its isoforms during tooth development. To determine its localization in BM of odontogenic neoplasms, immunohistochemistry using six anti- a (IV) chain-specific monoclonal antibodies was performed. Expression of a 1(IV)/ a 2(IV) and a 5(IV)/ a 6(IV) chains was stronger in the desmoplastic than in ordinary ameloblastomas. The adenomatoid odontogenic tumor distinctly expressed these chains in BM of cribriform areas and hyaline materials (which was also a 4(IV)-positive. These five chains also stained BM and tumor cells of ameloblastic fibroma. Present results suggest that collagen IV composition and distribution in the basement membranes of odontogenic neoplasms plays a key role in tumor growth and progression.

Original languageEnglish
Pages (from-to)130-131
Number of pages2
JournalJournal of Hard Tissue Biology
Volume14
Issue number2
DOIs
Publication statusPublished - 2005

Fingerprint

Odontogenic Tumors
Basement Membrane
Collagen
Tumors
Neoplasms
Ameloblastoma
Hyalin
Monoclonal antibodies
Fibroma
Collagen Type IV
Tooth
Protein Isoforms
Immunohistochemistry
Monoclonal Antibodies
Cells
Growth
Chemical analysis

Keywords

  • Ameloblastoma
  • Basement membrane
  • Type IV collagen

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry
  • Biomaterials
  • Orthopedics and Sports Medicine
  • Dentistry(all)
  • Cell Biology

Cite this

Expression of Collagen IV a1 to a6 Chains in Basement Membranes of Odontogenic Tumors. / Nagatsuka, Hitoshi; Fujii, Eiki; Tamamura, Ryo; Katase, Naoki; Nagai, Noriyuki; Siar, Chong Huat; Morimoto, Yasushi.

In: Journal of Hard Tissue Biology, Vol. 14, No. 2, 2005, p. 130-131.

Research output: Contribution to journalArticle

Nagatsuka, H, Fujii, E, Tamamura, R, Katase, N, Nagai, N, Siar, CH & Morimoto, Y 2005, 'Expression of Collagen IV a1 to a6 Chains in Basement Membranes of Odontogenic Tumors', Journal of Hard Tissue Biology, vol. 14, no. 2, pp. 130-131. https://doi.org/10.2485/jhtb.14.130
Nagatsuka, Hitoshi ; Fujii, Eiki ; Tamamura, Ryo ; Katase, Naoki ; Nagai, Noriyuki ; Siar, Chong Huat ; Morimoto, Yasushi. / Expression of Collagen IV a1 to a6 Chains in Basement Membranes of Odontogenic Tumors. In: Journal of Hard Tissue Biology. 2005 ; Vol. 14, No. 2. pp. 130-131.
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