Expression of cIAP-1 correlates with nodal metastasis in squamous cell carcinoma of the tongue

S. Qi, S. Mogi, H. Tsuda, Y. Tanaka, K. Kozaki, I. Imoto, J. Inazawa, S. Hasegawa, K. Omura

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Cellular inhibitor-of-apoptosis protein 1 (cIAP-1) is a member of the inhibitor-of- apoptosis protein family, which predominantly regulates apoptosis. It has been suggested that expression of cIAP-1 correlates with certain clinicopathological features. The possible significance of cIAP-1 expression in cervical lymph node metastasis of tongue squamous cell carcinoma (SCC) is investigated. Seventy-five tongue SCCs were analyzed by immunohistochemistry. cIAP-1 immunoreactivity patterns were nuclear in 38 (51%), cytoplasmic in 47 (63%), and concurrent in 37 (49%) cases. Nuclear, cytoplasmic and concurrent cIAP-1 immunoreactions were significantly correlated with lymph node metastasis in tongue SCCs (P = 0.0011, 0.0012, and 0.0006, respectively). The cleaved caspase-3, which is a marker of tumor apoptosis, and Ki-67 index, which is a marker of tumor proliferation, were immunohistochemically examined in 21 tongue SCCs with concurrent nuclear and cytoplasmic cIAP-1 expression and with metastasis, and in 23 tongue SCCs without concurrent nuclear and cytoplasmic cIAP-1 expression and without metastasis. Concurrent cIAP-1 expression was inversely correlated with caspase-3 (P = 0.0066), but was positively correlated with Ki-67 expression (P = 0.0028). The mode of invasion was associated with lymph node metastasis (P = 0.014) and differentiation (P = 0.013), but was not correlated with cIAP-1 expression. There was no statistically significant correlation between nuclear or cytoplasmic cIAP-1 expression and the clinicopathological factors of gender, age, clinical stage or differentiation. These results suggest that both patterns of cIAP-1 are useful markers for predicting cervical lymph node metastasis in tongue SCC.

Original languageEnglish
Pages (from-to)1047-1053
Number of pages7
JournalInternational Journal of Oral and Maxillofacial Surgery
Volume37
Issue number11
DOIs
Publication statusPublished - Nov 1 2008

Keywords

  • cIAP-1
  • lymph node metastasis
  • squamous cell carcinoma
  • tongue cancer

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

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