Abstract
Cellular inhibitor-of-apoptosis protein 1 (cIAP-1) is a member of the inhibitor-of- apoptosis protein family, which predominantly regulates apoptosis. It has been suggested that expression of cIAP-1 correlates with certain clinicopathological features. The possible significance of cIAP-1 expression in cervical lymph node metastasis of tongue squamous cell carcinoma (SCC) is investigated. Seventy-five tongue SCCs were analyzed by immunohistochemistry. cIAP-1 immunoreactivity patterns were nuclear in 38 (51%), cytoplasmic in 47 (63%), and concurrent in 37 (49%) cases. Nuclear, cytoplasmic and concurrent cIAP-1 immunoreactions were significantly correlated with lymph node metastasis in tongue SCCs (P = 0.0011, 0.0012, and 0.0006, respectively). The cleaved caspase-3, which is a marker of tumor apoptosis, and Ki-67 index, which is a marker of tumor proliferation, were immunohistochemically examined in 21 tongue SCCs with concurrent nuclear and cytoplasmic cIAP-1 expression and with metastasis, and in 23 tongue SCCs without concurrent nuclear and cytoplasmic cIAP-1 expression and without metastasis. Concurrent cIAP-1 expression was inversely correlated with caspase-3 (P = 0.0066), but was positively correlated with Ki-67 expression (P = 0.0028). The mode of invasion was associated with lymph node metastasis (P = 0.014) and differentiation (P = 0.013), but was not correlated with cIAP-1 expression. There was no statistically significant correlation between nuclear or cytoplasmic cIAP-1 expression and the clinicopathological factors of gender, age, clinical stage or differentiation. These results suggest that both patterns of cIAP-1 are useful markers for predicting cervical lymph node metastasis in tongue SCC.
| Original language | English |
|---|---|
| Pages (from-to) | 1047-1053 |
| Number of pages | 7 |
| Journal | International Journal of Oral and Maxillofacial Surgery |
| Volume | 37 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 2008 |
| Externally published | Yes |
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Keywords
- cIAP-1
- lymph node metastasis
- squamous cell carcinoma
- tongue cancer
ASJC Scopus subject areas
- Oral Surgery
- Otorhinolaryngology
- Surgery
Cite this
Expression of cIAP-1 correlates with nodal metastasis in squamous cell carcinoma of the tongue. / Qi, S.; Mogi, S.; Tsuda, H.; Tanaka, Y.; Kozaki, K.; Imoto, I.; Inazawa, J.; Hasegawa, S.; Omura, K.
In: International Journal of Oral and Maxillofacial Surgery, Vol. 37, No. 11, 11.2008, p. 1047-1053.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Expression of cIAP-1 correlates with nodal metastasis in squamous cell carcinoma of the tongue
AU - Qi, S.
AU - Mogi, S.
AU - Tsuda, H.
AU - Tanaka, Y.
AU - Kozaki, K.
AU - Imoto, I.
AU - Inazawa, J.
AU - Hasegawa, S.
AU - Omura, K.
PY - 2008/11
Y1 - 2008/11
N2 - Cellular inhibitor-of-apoptosis protein 1 (cIAP-1) is a member of the inhibitor-of- apoptosis protein family, which predominantly regulates apoptosis. It has been suggested that expression of cIAP-1 correlates with certain clinicopathological features. The possible significance of cIAP-1 expression in cervical lymph node metastasis of tongue squamous cell carcinoma (SCC) is investigated. Seventy-five tongue SCCs were analyzed by immunohistochemistry. cIAP-1 immunoreactivity patterns were nuclear in 38 (51%), cytoplasmic in 47 (63%), and concurrent in 37 (49%) cases. Nuclear, cytoplasmic and concurrent cIAP-1 immunoreactions were significantly correlated with lymph node metastasis in tongue SCCs (P = 0.0011, 0.0012, and 0.0006, respectively). The cleaved caspase-3, which is a marker of tumor apoptosis, and Ki-67 index, which is a marker of tumor proliferation, were immunohistochemically examined in 21 tongue SCCs with concurrent nuclear and cytoplasmic cIAP-1 expression and with metastasis, and in 23 tongue SCCs without concurrent nuclear and cytoplasmic cIAP-1 expression and without metastasis. Concurrent cIAP-1 expression was inversely correlated with caspase-3 (P = 0.0066), but was positively correlated with Ki-67 expression (P = 0.0028). The mode of invasion was associated with lymph node metastasis (P = 0.014) and differentiation (P = 0.013), but was not correlated with cIAP-1 expression. There was no statistically significant correlation between nuclear or cytoplasmic cIAP-1 expression and the clinicopathological factors of gender, age, clinical stage or differentiation. These results suggest that both patterns of cIAP-1 are useful markers for predicting cervical lymph node metastasis in tongue SCC.
AB - Cellular inhibitor-of-apoptosis protein 1 (cIAP-1) is a member of the inhibitor-of- apoptosis protein family, which predominantly regulates apoptosis. It has been suggested that expression of cIAP-1 correlates with certain clinicopathological features. The possible significance of cIAP-1 expression in cervical lymph node metastasis of tongue squamous cell carcinoma (SCC) is investigated. Seventy-five tongue SCCs were analyzed by immunohistochemistry. cIAP-1 immunoreactivity patterns were nuclear in 38 (51%), cytoplasmic in 47 (63%), and concurrent in 37 (49%) cases. Nuclear, cytoplasmic and concurrent cIAP-1 immunoreactions were significantly correlated with lymph node metastasis in tongue SCCs (P = 0.0011, 0.0012, and 0.0006, respectively). The cleaved caspase-3, which is a marker of tumor apoptosis, and Ki-67 index, which is a marker of tumor proliferation, were immunohistochemically examined in 21 tongue SCCs with concurrent nuclear and cytoplasmic cIAP-1 expression and with metastasis, and in 23 tongue SCCs without concurrent nuclear and cytoplasmic cIAP-1 expression and without metastasis. Concurrent cIAP-1 expression was inversely correlated with caspase-3 (P = 0.0066), but was positively correlated with Ki-67 expression (P = 0.0028). The mode of invasion was associated with lymph node metastasis (P = 0.014) and differentiation (P = 0.013), but was not correlated with cIAP-1 expression. There was no statistically significant correlation between nuclear or cytoplasmic cIAP-1 expression and the clinicopathological factors of gender, age, clinical stage or differentiation. These results suggest that both patterns of cIAP-1 are useful markers for predicting cervical lymph node metastasis in tongue SCC.
KW - cIAP-1
KW - lymph node metastasis
KW - squamous cell carcinoma
KW - tongue cancer
UR - http://www.scopus.com/inward/record.url?scp=55549084196&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=55549084196&partnerID=8YFLogxK
U2 - 10.1016/j.ijom.2008.06.004
DO - 10.1016/j.ijom.2008.06.004
M3 - Article
C2 - 18621506
AN - SCOPUS:55549084196
VL - 37
SP - 1047
EP - 1053
JO - International Journal of Oral and Maxillofacial Surgery
JF - International Journal of Oral and Maxillofacial Surgery
SN - 0901-5027
IS - 11
ER -