Expression of calbindin-D28K by reactive astrocytes in gerbil hippocampus after ischaemia

Tetsuhiko Toyoshima, Shinichi Yamagami, Bushra Y. Ahmed, Li Jin, Osamu Miyamoto, Toshifumi Itano, Masaaki Tokuda, Hideki Matsui, Osamu Hatase

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Calbindin-D28K (calbindin) is a member of the superfamily of calcium-binding proteins that is implicated in the regulation of intracellular calcium. In the adult mammalian brain, calbindin was thought to be present only in neurones, where it is believed to serve a neuroprotective role. We now report the expression of calbindin after ischaemia in reactive astrocytes in the CA1 subfield of the hippocampus. Since other calcium-binding proteins, such as S-100 and calmodulin, which induce transformation or proliferation of glia, occur in astrocytes, it is conceivable that the expression of calbindin after ischaemia might be an important part of the process of gliosis.

Original languageEnglish
Pages (from-to)2087-2091
Number of pages5
JournalNeuroReport
Volume7
Issue number13
Publication statusPublished - 1996
Externally publishedYes

Fingerprint

Calbindin 1
Calbindins
Gerbillinae
Astrocytes
Hippocampus
Ischemia
Calcium-Binding Proteins
Gliosis
Calmodulin
Neuroglia
Calcium
Neurons
Brain

Keywords

  • Calbindin-D28K
  • Hippocampus
  • Immunocytochemistry
  • Reactive astrocytes
  • Transient ischaemia

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Toyoshima, T., Yamagami, S., Ahmed, B. Y., Jin, L., Miyamoto, O., Itano, T., ... Hatase, O. (1996). Expression of calbindin-D28K by reactive astrocytes in gerbil hippocampus after ischaemia. NeuroReport, 7(13), 2087-2091.

Expression of calbindin-D28K by reactive astrocytes in gerbil hippocampus after ischaemia. / Toyoshima, Tetsuhiko; Yamagami, Shinichi; Ahmed, Bushra Y.; Jin, Li; Miyamoto, Osamu; Itano, Toshifumi; Tokuda, Masaaki; Matsui, Hideki; Hatase, Osamu.

In: NeuroReport, Vol. 7, No. 13, 1996, p. 2087-2091.

Research output: Contribution to journalArticle

Toyoshima, T, Yamagami, S, Ahmed, BY, Jin, L, Miyamoto, O, Itano, T, Tokuda, M, Matsui, H & Hatase, O 1996, 'Expression of calbindin-D28K by reactive astrocytes in gerbil hippocampus after ischaemia', NeuroReport, vol. 7, no. 13, pp. 2087-2091.
Toyoshima T, Yamagami S, Ahmed BY, Jin L, Miyamoto O, Itano T et al. Expression of calbindin-D28K by reactive astrocytes in gerbil hippocampus after ischaemia. NeuroReport. 1996;7(13):2087-2091.
Toyoshima, Tetsuhiko ; Yamagami, Shinichi ; Ahmed, Bushra Y. ; Jin, Li ; Miyamoto, Osamu ; Itano, Toshifumi ; Tokuda, Masaaki ; Matsui, Hideki ; Hatase, Osamu. / Expression of calbindin-D28K by reactive astrocytes in gerbil hippocampus after ischaemia. In: NeuroReport. 1996 ; Vol. 7, No. 13. pp. 2087-2091.
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