Abstract
Expression of Bcl-2 protein and Fas antigens was analyzed in 12 cases of follicular lymphoma and 32 cases of diffuse lymphoma, including 22 B cell and 10 T-cell lymphomas. It was shown that 75% of follicular lymphomas had clear expression of both Bcl-2 protein and Fas antigen. Thus, follicular lymphomas may have a growth advantage due to their high expression of Bcl-2 protein, which tended to impede apoptosis mediated by Fas antigen. On the other hand, diffuse lymphomas showed various patterns; 28% were double positive, 16% were only Bcl-2 protein-positive, 28% were only Fas antigen-positive, and 28% were double negative or equivocal. Cytocidal assay of seven leukemia/lymphoma cell lines using anti-human Fas monoclonal antibody revealed that overexpression of Bcl-2 protein tended to impede apoptosis mediated by Fas antigen. However, this inhibitory effect of Bcl-2 protein was incomplete and its effect might be dependent upon cell type.
| Original language | English |
|---|---|
| Pages (from-to) | 330-337 |
| Number of pages | 8 |
| Journal | American Journal of Pathology |
| Volume | 145 |
| Issue number | 2 |
| Publication status | Published - Aug 1994 |
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ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
Expression of Bcl-2 protein and Fas antigen in non-Hodgkin's lymphomas. / Kondo, Eisaku; Yoshino, Tadashi; Yamadori, Ichiro; Matsuo, Yoshinobu; Kawasaki, Nobuhiro; Minowada, Jun; Akagi, Tadaatsu.
In: American Journal of Pathology, Vol. 145, No. 2, 08.1994, p. 330-337.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Expression of Bcl-2 protein and Fas antigen in non-Hodgkin's lymphomas
AU - Kondo, Eisaku
AU - Yoshino, Tadashi
AU - Yamadori, Ichiro
AU - Matsuo, Yoshinobu
AU - Kawasaki, Nobuhiro
AU - Minowada, Jun
AU - Akagi, Tadaatsu
PY - 1994/8
Y1 - 1994/8
N2 - Expression of Bcl-2 protein and Fas antigens was analyzed in 12 cases of follicular lymphoma and 32 cases of diffuse lymphoma, including 22 B cell and 10 T-cell lymphomas. It was shown that 75% of follicular lymphomas had clear expression of both Bcl-2 protein and Fas antigen. Thus, follicular lymphomas may have a growth advantage due to their high expression of Bcl-2 protein, which tended to impede apoptosis mediated by Fas antigen. On the other hand, diffuse lymphomas showed various patterns; 28% were double positive, 16% were only Bcl-2 protein-positive, 28% were only Fas antigen-positive, and 28% were double negative or equivocal. Cytocidal assay of seven leukemia/lymphoma cell lines using anti-human Fas monoclonal antibody revealed that overexpression of Bcl-2 protein tended to impede apoptosis mediated by Fas antigen. However, this inhibitory effect of Bcl-2 protein was incomplete and its effect might be dependent upon cell type.
AB - Expression of Bcl-2 protein and Fas antigens was analyzed in 12 cases of follicular lymphoma and 32 cases of diffuse lymphoma, including 22 B cell and 10 T-cell lymphomas. It was shown that 75% of follicular lymphomas had clear expression of both Bcl-2 protein and Fas antigen. Thus, follicular lymphomas may have a growth advantage due to their high expression of Bcl-2 protein, which tended to impede apoptosis mediated by Fas antigen. On the other hand, diffuse lymphomas showed various patterns; 28% were double positive, 16% were only Bcl-2 protein-positive, 28% were only Fas antigen-positive, and 28% were double negative or equivocal. Cytocidal assay of seven leukemia/lymphoma cell lines using anti-human Fas monoclonal antibody revealed that overexpression of Bcl-2 protein tended to impede apoptosis mediated by Fas antigen. However, this inhibitory effect of Bcl-2 protein was incomplete and its effect might be dependent upon cell type.
UR - http://www.scopus.com/inward/record.url?scp=0028017552&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028017552&partnerID=8YFLogxK
M3 - Article
C2 - 7519826
AN - SCOPUS:0028017552
VL - 145
SP - 330
EP - 337
JO - American Journal of Pathology
JF - American Journal of Pathology
SN - 0002-9440
IS - 2
ER -