Expression of Bcl-2 protein and Fas antigen in non-Hodgkin's lymphomas

Eisaku Kondo, Tadashi Yoshino, Ichiro Yamadori, Yoshinobu Matsuo, Nobuhiro Kawasaki, Jun Minowada, Tadaatsu Akagi

Research output: Contribution to journalArticle

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Abstract

Expression of Bcl-2 protein and Fas antigens was analyzed in 12 cases of follicular lymphoma and 32 cases of diffuse lymphoma, including 22 B cell and 10 T-cell lymphomas. It was shown that 75% of follicular lymphomas had clear expression of both Bcl-2 protein and Fas antigen. Thus, follicular lymphomas may have a growth advantage due to their high expression of Bcl-2 protein, which tended to impede apoptosis mediated by Fas antigen. On the other hand, diffuse lymphomas showed various patterns; 28% were double positive, 16% were only Bcl-2 protein-positive, 28% were only Fas antigen-positive, and 28% were double negative or equivocal. Cytocidal assay of seven leukemia/lymphoma cell lines using anti-human Fas monoclonal antibody revealed that overexpression of Bcl-2 protein tended to impede apoptosis mediated by Fas antigen. However, this inhibitory effect of Bcl-2 protein was incomplete and its effect might be dependent upon cell type.

Original languageEnglish
Pages (from-to)330-337
Number of pages8
JournalAmerican Journal of Pathology
Volume145
Issue number2
Publication statusPublished - Aug 1994

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CD95 Antigens
Non-Hodgkin's Lymphoma
Follicular Lymphoma
Proteins
anti-Fas monoclonal antibody
Apoptosis
T-Cell Lymphoma
Lymphoma
Leukemia
B-Lymphocytes
Cell Line
Growth

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Kondo, E., Yoshino, T., Yamadori, I., Matsuo, Y., Kawasaki, N., Minowada, J., & Akagi, T. (1994). Expression of Bcl-2 protein and Fas antigen in non-Hodgkin's lymphomas. American Journal of Pathology, 145(2), 330-337.

Expression of Bcl-2 protein and Fas antigen in non-Hodgkin's lymphomas. / Kondo, Eisaku; Yoshino, Tadashi; Yamadori, Ichiro; Matsuo, Yoshinobu; Kawasaki, Nobuhiro; Minowada, Jun; Akagi, Tadaatsu.

In: American Journal of Pathology, Vol. 145, No. 2, 08.1994, p. 330-337.

Research output: Contribution to journalArticle

Kondo, E, Yoshino, T, Yamadori, I, Matsuo, Y, Kawasaki, N, Minowada, J & Akagi, T 1994, 'Expression of Bcl-2 protein and Fas antigen in non-Hodgkin's lymphomas', American Journal of Pathology, vol. 145, no. 2, pp. 330-337.
Kondo E, Yoshino T, Yamadori I, Matsuo Y, Kawasaki N, Minowada J et al. Expression of Bcl-2 protein and Fas antigen in non-Hodgkin's lymphomas. American Journal of Pathology. 1994 Aug;145(2):330-337.
Kondo, Eisaku ; Yoshino, Tadashi ; Yamadori, Ichiro ; Matsuo, Yoshinobu ; Kawasaki, Nobuhiro ; Minowada, Jun ; Akagi, Tadaatsu. / Expression of Bcl-2 protein and Fas antigen in non-Hodgkin's lymphomas. In: American Journal of Pathology. 1994 ; Vol. 145, No. 2. pp. 330-337.
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