Expression of Bcl-2 protein and Fas antigen in non-Hodgkin's lymphomas

Eisaku Kondo, Tadashi Yoshino, Ichiro Yamadori, Yoshinobu Matsuo, Nobuhiro Kawasaki, Jun Minowada, Tadaatsu Akagi

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Abstract

Expression of Bcl-2 protein and Fas antigens was analyzed in 12 cases of follicular lymphoma and 32 cases of diffuse lymphoma, including 22 B cell and 10 T-cell lymphomas. It was shown that 75% of follicular lymphomas had clear expression of both Bcl-2 protein and Fas antigen. Thus, follicular lymphomas may have a growth advantage due to their high expression of Bcl-2 protein, which tended to impede apoptosis mediated by Fas antigen. On the other hand, diffuse lymphomas showed various patterns; 28% were double positive, 16% were only Bcl-2 protein-positive, 28% were only Fas antigen-positive, and 28% were double negative or equivocal. Cytocidal assay of seven leukemia/lymphoma cell lines using anti-human Fas monoclonal antibody revealed that overexpression of Bcl-2 protein tended to impede apoptosis mediated by Fas antigen. However, this inhibitory effect of Bcl-2 protein was incomplete and its effect might be dependent upon cell type.

Original languageEnglish
Pages (from-to)330-337
Number of pages8
JournalAmerican Journal of Pathology
Volume145
Issue number2
Publication statusPublished - Aug 1 1994

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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    Kondo, E., Yoshino, T., Yamadori, I., Matsuo, Y., Kawasaki, N., Minowada, J., & Akagi, T. (1994). Expression of Bcl-2 protein and Fas antigen in non-Hodgkin's lymphomas. American Journal of Pathology, 145(2), 330-337.