Expression of antiangiogenic prolactin fragments in the placentas of women with pregnancy induced hypertension

Akio Masumoto, Hisashi Masuyama, Norio Takamoto, Yoichiro Akahori, Yuji Hiramatsu

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

It has been reported that prolactin (PRL) is cleaved to 14 or 16 kDa fragments by cathepsin D in vitro and in vivo, and that such fragments exhibit antiangiogenic and proapoptotic properties. The aim of this study was to investigate the relationship between pregnancy induced hypertension (PIH) and the placental expression of antiangiogenic PRL fragments and cathepsin D. Placental expression of PRL fragments and cathepsin D was evaluated by Western blot analysis in a group of 9 pregnant women consisting of 5 normal pregnancies and 4 severe PIH cases. Antiangiogenic PRL fragments were detected in 4 placental samples from all PIH cases but not detected in those from normal pregnancies (p <0.05). The expression of cathepsin D in PIH placentas was significantly lower than that in those without PIH (p

Original languageEnglish
Pages (from-to)249-255
Number of pages7
JournalActa Medica Okayama
Volume64
Issue number4
Publication statusPublished - Aug 2010

Fingerprint

Pregnancy Induced Hypertension
Cathepsin D
Prolactin
Placenta
Pregnancy
Pregnant Women
Western Blotting

Keywords

  • Cathepsin-D
  • Preeclampsia
  • Pregnancy induced hypertension
  • Prolactin
  • Prolactin fragment

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Expression of antiangiogenic prolactin fragments in the placentas of women with pregnancy induced hypertension. / Masumoto, Akio; Masuyama, Hisashi; Takamoto, Norio; Akahori, Yoichiro; Hiramatsu, Yuji.

In: Acta Medica Okayama, Vol. 64, No. 4, 08.2010, p. 249-255.

Research output: Contribution to journalArticle

Masumoto, Akio ; Masuyama, Hisashi ; Takamoto, Norio ; Akahori, Yoichiro ; Hiramatsu, Yuji. / Expression of antiangiogenic prolactin fragments in the placentas of women with pregnancy induced hypertension. In: Acta Medica Okayama. 2010 ; Vol. 64, No. 4. pp. 249-255.
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