Expression of adrenoreceptor and melanocortin 2 receptor mRNA in various tissues from SHR.CG-LEPRCP/NDMCR rats

Naoki Harikai, Rie Shinnou, Masanori Semma, Satoshi Tanaka, Atsushi Ichikawa

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

1. Obese and spontaneously hypertensive SHR.Cg-Leprcp/NDmcr (cp/cp) rats exhibit phenotypic features that resemble metabolic syndrome. 2. As an initial approach in defining the roles of the sympathetic nervous system and hypothalamic-pituitary-adrenal axis in the mechanism of metabolic syndrome, we examined the gene expression of the adrenoreceptors (a1A, a 1B, a1D, a2A, a2B, a2C, b1, b2 and b3) and the adrenocorticotrophin receptor melanocortin 2 receptor (mc2r) in various tissues from cp/cp rats using real-time reverse transcription-polymerase chain reaction. 3. In cp/cp rats, the gene expression of a1A-, a1B- and b 1-adrenoceptors in the heart was increased compared with that in Wistar-Kyoto (WKY) rats and lean spontaneously hypertensive rats, namely SHR.Cg-Leprcp/NDmcr (+/+) rats. However, the gene expression of b2-, b3-adrenoceptors and mc2r in adipose tissue was decreased compared with that in +/+ and WKY rats. These changes in the gene expression in cp/cp rats may be associated with the development and persistence of metabolic syndrome.

Original languageEnglish
Pages (from-to)S20-S22
JournalClinical and Experimental Pharmacology and Physiology
Volume34
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Nov 1 2007

Keywords

  • Hypothalamic-pituitary-adrenal axis
  • Metabolic syndrome
  • RNA
  • Spontaneously hypertensive rats
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

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