Expression and mutation analysis of her2 in head and neck squamous cell carcinoma

Mahmoud Al Sheikh Ali; Mehmet Gunduz; Esra Gunduz; Ryo Tamamura; Levent Bekir Beder; Naoki Katase; Omer Faruk Hatipoglu; Kunihiro Fukushima; Noboru Yamanaka; Kenji Shimizu; Hitoshi Nagatsuka

doi:10.3109/07357900903476778

Expression and mutation analysis of her2 in head and neck squamous cell carcinoma

Mahmoud Al Sheikh Ali, Mehmet Gunduz, Esra Gunduz, Ryo Tamamura, Levent Bekir Beder, Naoki Katase, Omer Faruk Hatipoglu, Kunihiro Fukushima, Noboru Yamanaka, Kenji Shimizu, Hitoshi Nagatsuka

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

We analyzed mutation and expression status of human epidermal growth factor receptor 2 (Her2) in head and neck squamous cell carcinoma (HNSCC) using single strand conformation polymorphism (SSCP) mutation analysis and immunohistochemistry (IHC). Mutations were absent in all 85 cases. Out of 57 cases available for IHC, Her2 protein expression was negative (0) in 40 tumors (70). Seventeen tumors (29.8) expressed Her2, among these 13 tumors (22.8%) showed a weak (+1) expression and 4 (7%) showed a moderate expression (+2), none showed a strong (+3) expression. There was not a significant association between expression and any of the patients' clinical variables or prognosis. Our results suggest that Her2 may not be useful as a molecular target in HNSCC.

Original language	English
Pages (from-to)	495-500
Number of pages	6
Journal	Cancer Investigation
Volume	28
Issue number	5
DOIs	https://doi.org/10.3109/07357900903476778
Publication status	Published - May 2010

Keywords

Head and neck cancer
Her2
Immunohistochemistry
Mutation

ASJC Scopus subject areas

Oncology
Cancer Research

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Expression and mutation analysis of her2 in head and neck squamous cell carcinoma. / Ali, Mahmoud Al Sheikh; Gunduz, Mehmet; Gunduz, Esra; Tamamura, Ryo; Beder, Levent Bekir; Katase, Naoki; Hatipoglu, Omer Faruk; Fukushima, Kunihiro; Yamanaka, Noboru; Shimizu, Kenji; Nagatsuka, Hitoshi.

In: Cancer Investigation, Vol. 28, No. 5, 05.2010, p. 495-500.

Research output: Contribution to journal › Article › peer-review

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abstract = "We analyzed mutation and expression status of human epidermal growth factor receptor 2 (Her2) in head and neck squamous cell carcinoma (HNSCC) using single strand conformation polymorphism (SSCP) mutation analysis and immunohistochemistry (IHC). Mutations were absent in all 85 cases. Out of 57 cases available for IHC, Her2 protein expression was negative (0) in 40 tumors (70). Seventeen tumors (29.8) expressed Her2, among these 13 tumors (22.8%) showed a weak (+1) expression and 4 (7%) showed a moderate expression (+2), none showed a strong (+3) expression. There was not a significant association between expression and any of the patients' clinical variables or prognosis. Our results suggest that Her2 may not be useful as a molecular target in HNSCC.",

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AU - Ali, Mahmoud Al Sheikh

AU - Gunduz, Mehmet

AU - Gunduz, Esra

AU - Tamamura, Ryo

AU - Beder, Levent Bekir

AU - Katase, Naoki

AU - Hatipoglu, Omer Faruk

AU - Fukushima, Kunihiro

AU - Yamanaka, Noboru

AU - Shimizu, Kenji

AU - Nagatsuka, Hitoshi

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N2 - We analyzed mutation and expression status of human epidermal growth factor receptor 2 (Her2) in head and neck squamous cell carcinoma (HNSCC) using single strand conformation polymorphism (SSCP) mutation analysis and immunohistochemistry (IHC). Mutations were absent in all 85 cases. Out of 57 cases available for IHC, Her2 protein expression was negative (0) in 40 tumors (70). Seventeen tumors (29.8) expressed Her2, among these 13 tumors (22.8%) showed a weak (+1) expression and 4 (7%) showed a moderate expression (+2), none showed a strong (+3) expression. There was not a significant association between expression and any of the patients' clinical variables or prognosis. Our results suggest that Her2 may not be useful as a molecular target in HNSCC.

AB - We analyzed mutation and expression status of human epidermal growth factor receptor 2 (Her2) in head and neck squamous cell carcinoma (HNSCC) using single strand conformation polymorphism (SSCP) mutation analysis and immunohistochemistry (IHC). Mutations were absent in all 85 cases. Out of 57 cases available for IHC, Her2 protein expression was negative (0) in 40 tumors (70). Seventeen tumors (29.8) expressed Her2, among these 13 tumors (22.8%) showed a weak (+1) expression and 4 (7%) showed a moderate expression (+2), none showed a strong (+3) expression. There was not a significant association between expression and any of the patients' clinical variables or prognosis. Our results suggest that Her2 may not be useful as a molecular target in HNSCC.

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