Expression and mutation analysis of her2 in head and neck squamous cell carcinoma

Mahmoud Al Sheikh Ali, Mehmet Gunduz, Esra Gunduz, Ryo Tamamura, Levent Bekir Beder, Naoki Katase, Omer Faruk Hatipoglu, Kunihiro Fukushima, Noboru Yamanaka, Kenji Shimizu, Hitoshi Nagatsuka

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14 Citations (Scopus)

Abstract

We analyzed mutation and expression status of human epidermal growth factor receptor 2 (Her2) in head and neck squamous cell carcinoma (HNSCC) using single strand conformation polymorphism (SSCP) mutation analysis and immunohistochemistry (IHC). Mutations were absent in all 85 cases. Out of 57 cases available for IHC, Her2 protein expression was negative (0) in 40 tumors (70). Seventeen tumors (29.8) expressed Her2, among these 13 tumors (22.8%) showed a weak (+1) expression and 4 (7%) showed a moderate expression (+2), none showed a strong (+3) expression. There was not a significant association between expression and any of the patients' clinical variables or prognosis. Our results suggest that Her2 may not be useful as a molecular target in HNSCC.

Original languageEnglish
Pages (from-to)495-500
Number of pages6
JournalCancer Investigation
Volume28
Issue number5
DOIs
Publication statusPublished - May 2010

Keywords

  • Head and neck cancer
  • Her2
  • Immunohistochemistry
  • Mutation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Ali, M. A. S., Gunduz, M., Gunduz, E., Tamamura, R., Beder, L. B., Katase, N., Hatipoglu, O. F., Fukushima, K., Yamanaka, N., Shimizu, K., & Nagatsuka, H. (2010). Expression and mutation analysis of her2 in head and neck squamous cell carcinoma. Cancer Investigation, 28(5), 495-500. https://doi.org/10.3109/07357900903476778