Expression and mutation analysis of her2 in head and neck squamous cell carcinoma

Mahmoud Al Sheikh Ali, Mehmet Gunduz, Esra Gunduz, Ryo Tamamura, Levent Bekir Beder, Naoki Katase, Omer Faruk Hatipoglu, Kunihiro Fukushima, Noboru Yamanaka, Kenji Shimizu, Hitoshi Nagatsuka

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We analyzed mutation and expression status of human epidermal growth factor receptor 2 (Her2) in head and neck squamous cell carcinoma (HNSCC) using single strand conformation polymorphism (SSCP) mutation analysis and immunohistochemistry (IHC). Mutations were absent in all 85 cases. Out of 57 cases available for IHC, Her2 protein expression was negative (0) in 40 tumors (70). Seventeen tumors (29.8) expressed Her2, among these 13 tumors (22.8%) showed a weak (+1) expression and 4 (7%) showed a moderate expression (+2), none showed a strong (+3) expression. There was not a significant association between expression and any of the patients' clinical variables or prognosis. Our results suggest that Her2 may not be useful as a molecular target in HNSCC.

Original languageEnglish
Pages (from-to)495-500
Number of pages6
JournalCancer Investigation
Volume28
Issue number5
DOIs
Publication statusPublished - May 2010

Fingerprint

Mutation
Immunohistochemistry
Neoplasms
human ERBB2 protein
Carcinoma, squamous cell of head and neck
Proteins

Keywords

  • Head and neck cancer
  • Her2
  • Immunohistochemistry
  • Mutation

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Expression and mutation analysis of her2 in head and neck squamous cell carcinoma. / Ali, Mahmoud Al Sheikh; Gunduz, Mehmet; Gunduz, Esra; Tamamura, Ryo; Beder, Levent Bekir; Katase, Naoki; Hatipoglu, Omer Faruk; Fukushima, Kunihiro; Yamanaka, Noboru; Shimizu, Kenji; Nagatsuka, Hitoshi.

In: Cancer Investigation, Vol. 28, No. 5, 05.2010, p. 495-500.

Research output: Contribution to journalArticle

Ali, MAS, Gunduz, M, Gunduz, E, Tamamura, R, Beder, LB, Katase, N, Hatipoglu, OF, Fukushima, K, Yamanaka, N, Shimizu, K & Nagatsuka, H 2010, 'Expression and mutation analysis of her2 in head and neck squamous cell carcinoma', Cancer Investigation, vol. 28, no. 5, pp. 495-500. https://doi.org/10.3109/07357900903476778
Ali MAS, Gunduz M, Gunduz E, Tamamura R, Beder LB, Katase N et al. Expression and mutation analysis of her2 in head and neck squamous cell carcinoma. Cancer Investigation. 2010 May;28(5):495-500. https://doi.org/10.3109/07357900903476778
Ali, Mahmoud Al Sheikh ; Gunduz, Mehmet ; Gunduz, Esra ; Tamamura, Ryo ; Beder, Levent Bekir ; Katase, Naoki ; Hatipoglu, Omer Faruk ; Fukushima, Kunihiro ; Yamanaka, Noboru ; Shimizu, Kenji ; Nagatsuka, Hitoshi. / Expression and mutation analysis of her2 in head and neck squamous cell carcinoma. In: Cancer Investigation. 2010 ; Vol. 28, No. 5. pp. 495-500.
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