Exposure of mouse to high gravitation forces induces long-term potentiation in the hippocampus

Masamitsu Ishii, Kazuhito Tomizawa, Masayuki Matsushita, Hideki Matsui

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The central nervous system is highly plastic and has been shown to undergo both transient and chronic adaptive changes in response to environmental influences. The purpose of this study was to investigate the effect of hypergravic field on long-term potentiation (LTP) in the mouse hippocampus. Exposure of mice to 4G fields for 48 h had no effect on input-output coupling during extracellular stimulation of Schaffer collaterals and paired pulse facilitation, suggesting that the hypergravic exposure had no detrimental effect on basal neurotransmission in the hippocampus. However, the exposure to 4G fields for 48 h significantly induced LTP compared with the control mouse hippocampus. In contrast, no significant changes of late-phase LTP (L-LTP) were found in the hippocampi of mice exposed to the hypergravic field. Exposure of mice to 4G fields for 48 h enhanced AMPA receptor phosphorylation but not cyclic AMP-responsive element binding protein (CREB) phosphorylation. These results suggest that exposure to hyperdynamic fields influences the synaptic plasticity in the hippocampus.

Original languageEnglish
Pages (from-to)143-149
Number of pages7
JournalActa medica Okayama
Volume58
Issue number3
Publication statusPublished - Jun 2004

Keywords

  • AMPA receptor
  • Cyclic AMP-responsive element binding protein (CREB)
  • Long-term potentiation (LTP)
  • Plasticity
  • Synapse

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Ishii, M., Tomizawa, K., Matsushita, M., & Matsui, H. (2004). Exposure of mouse to high gravitation forces induces long-term potentiation in the hippocampus. Acta medica Okayama, 58(3), 143-149.