Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer

Ken Ichi Kozaki, Issei Imoto, Seiki Mogi, Ken Omura, Johji Inazawa

Research output: Contribution to journalArticle

473 Citations (Scopus)

Abstract

In the last few years, microRNAs (miRNA) have started a revolution in molecular biology and emerged as key players in the carcinogenesis. They have been identified in various tumor types, showing that different sets of miRNAs are usually deregulated in different cancers. To identify the miRNA signature that was specific for oral squamous cell carcinoma (OSCC), we first examined expression profiles of 148 miRNAs in a panel of 18 OSCC cell lines and the immortalized oral keratinocyte line RT7 as a control. Compared with RT7, the expression of 54 miRNAs (36.5%) was frequently down-regulated in OSCC lines (

Original languageEnglish
Pages (from-to)2094-2105
Number of pages12
JournalCancer Research
Volume68
Issue number7
DOIs
Publication statusPublished - Apr 1 2008
Externally publishedYes

Fingerprint

Mouth Neoplasms
MicroRNAs
DNA
Squamous Cell Carcinoma
Neoplasms
Cell Line
Keratinocytes
Molecular Biology
Carcinogenesis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer. / Kozaki, Ken Ichi; Imoto, Issei; Mogi, Seiki; Omura, Ken; Inazawa, Johji.

In: Cancer Research, Vol. 68, No. 7, 01.04.2008, p. 2094-2105.

Research output: Contribution to journalArticle

Kozaki, Ken Ichi ; Imoto, Issei ; Mogi, Seiki ; Omura, Ken ; Inazawa, Johji. / Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer. In: Cancer Research. 2008 ; Vol. 68, No. 7. pp. 2094-2105.
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