Abstract
A new antithrombogenic stent using ion beam surface modification nanotechnology was evaluated. The ion stent is being developed to inhibit acute and chronic stent-related thrombosis. Thirty self-expanding mesh stents were fabricated from Ti-Ni metal wires with a dimension of 4 mm (diameter) × 25 mm (length) × 0.15 mm (thickness). Twenty stents were coated with type I collagen and irradiated with a He+ ion beam at an energy of 150 keV with fluences of 1 × 1014 ions/cm2 (ion stent group). Ten stents had no treatment (non-ion stent group). The self-expanding stents were implanted into the right and left peripheral femoral arteries of 15 beagle dogs (vessel diameter approximately 3 mm) via a 6Fr catheter under fluoroscopic guidance. Heparin (100 units/kg) was administered intravenously before implantation. Following stent implantation, no antiplatelet or anticoagulant drugs were administered. The 1-month patency rate for the non-ion stent group was 10% (1/10), and for the ion stent group it was 80% (16/20) with no anticoagulant or antiplatelet drugs given after stent implantation (P = 0.0004 by Fisher's exact test). Ten stents remain patent after 2 years in vivo with no anticoagulant or antiplatelet drugs. These results indicate that He + ion-implanted collagen-coated Ti-Ni self-expanding stents have excellent antithrombogenicity and biocompatibility. This ion stent is promising for coronary and cerebral stent applications.
| Original language | English |
|---|---|
| Pages (from-to) | 456-463 |
| Number of pages | 8 |
| Journal | Artificial Organs |
| Volume | 33 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 2009 |
| Externally published | Yes |
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Keywords
- Cerebral stent
- Collagen
- Coronary stent
- Ion beam surface modification
- Neointima
ASJC Scopus subject areas
- Biomaterials
- Biomedical Engineering
- Bioengineering
- Medicine (miscellaneous)
Cite this
Experimental evaluation of a nNew antithrombogenic stent using ion beam surface modification. / Sugita, Yoichi; Suzuki, Yoshiaki; Someya, Kenji; Ogawa, Akira; Furuhata, Hiroshi; Miyoshi, Shinichiro; Motomura, Tadashi; Miyamoto, Hiroshi; Igo, Stephen; Nosé, Yukihiko.
In: Artificial Organs, Vol. 33, No. 6, 06.2009, p. 456-463.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Experimental evaluation of a nNew antithrombogenic stent using ion beam surface modification
AU - Sugita, Yoichi
AU - Suzuki, Yoshiaki
AU - Someya, Kenji
AU - Ogawa, Akira
AU - Furuhata, Hiroshi
AU - Miyoshi, Shinichiro
AU - Motomura, Tadashi
AU - Miyamoto, Hiroshi
AU - Igo, Stephen
AU - Nosé, Yukihiko
PY - 2009/6
Y1 - 2009/6
N2 - A new antithrombogenic stent using ion beam surface modification nanotechnology was evaluated. The ion stent is being developed to inhibit acute and chronic stent-related thrombosis. Thirty self-expanding mesh stents were fabricated from Ti-Ni metal wires with a dimension of 4 mm (diameter) × 25 mm (length) × 0.15 mm (thickness). Twenty stents were coated with type I collagen and irradiated with a He+ ion beam at an energy of 150 keV with fluences of 1 × 1014 ions/cm2 (ion stent group). Ten stents had no treatment (non-ion stent group). The self-expanding stents were implanted into the right and left peripheral femoral arteries of 15 beagle dogs (vessel diameter approximately 3 mm) via a 6Fr catheter under fluoroscopic guidance. Heparin (100 units/kg) was administered intravenously before implantation. Following stent implantation, no antiplatelet or anticoagulant drugs were administered. The 1-month patency rate for the non-ion stent group was 10% (1/10), and for the ion stent group it was 80% (16/20) with no anticoagulant or antiplatelet drugs given after stent implantation (P = 0.0004 by Fisher's exact test). Ten stents remain patent after 2 years in vivo with no anticoagulant or antiplatelet drugs. These results indicate that He + ion-implanted collagen-coated Ti-Ni self-expanding stents have excellent antithrombogenicity and biocompatibility. This ion stent is promising for coronary and cerebral stent applications.
AB - A new antithrombogenic stent using ion beam surface modification nanotechnology was evaluated. The ion stent is being developed to inhibit acute and chronic stent-related thrombosis. Thirty self-expanding mesh stents were fabricated from Ti-Ni metal wires with a dimension of 4 mm (diameter) × 25 mm (length) × 0.15 mm (thickness). Twenty stents were coated with type I collagen and irradiated with a He+ ion beam at an energy of 150 keV with fluences of 1 × 1014 ions/cm2 (ion stent group). Ten stents had no treatment (non-ion stent group). The self-expanding stents were implanted into the right and left peripheral femoral arteries of 15 beagle dogs (vessel diameter approximately 3 mm) via a 6Fr catheter under fluoroscopic guidance. Heparin (100 units/kg) was administered intravenously before implantation. Following stent implantation, no antiplatelet or anticoagulant drugs were administered. The 1-month patency rate for the non-ion stent group was 10% (1/10), and for the ion stent group it was 80% (16/20) with no anticoagulant or antiplatelet drugs given after stent implantation (P = 0.0004 by Fisher's exact test). Ten stents remain patent after 2 years in vivo with no anticoagulant or antiplatelet drugs. These results indicate that He + ion-implanted collagen-coated Ti-Ni self-expanding stents have excellent antithrombogenicity and biocompatibility. This ion stent is promising for coronary and cerebral stent applications.
KW - Cerebral stent
KW - Collagen
KW - Coronary stent
KW - Ion beam surface modification
KW - Neointima
UR - http://www.scopus.com/inward/record.url?scp=66449121405&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=66449121405&partnerID=8YFLogxK
U2 - 10.1111/j.1525-1594.2009.00747.x
DO - 10.1111/j.1525-1594.2009.00747.x
M3 - Article
C2 - 19473141
AN - SCOPUS:66449121405
VL - 33
SP - 456
EP - 463
JO - Artificial Organs
JF - Artificial Organs
SN - 0160-564X
IS - 6
ER -