Experimental evaluation of a nNew antithrombogenic stent using ion beam surface modification

Yoichi Sugita, Yoshiaki Suzuki, Kenji Someya, Akira Ogawa, Hiroshi Furuhata, Shinichiro Miyoshi, Tadashi Motomura, Hiroshi Miyamoto, Stephen Igo, Yukihiko Nosé

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


A new antithrombogenic stent using ion beam surface modification nanotechnology was evaluated. The ion stent is being developed to inhibit acute and chronic stent-related thrombosis. Thirty self-expanding mesh stents were fabricated from Ti-Ni metal wires with a dimension of 4 mm (diameter) × 25 mm (length) × 0.15 mm (thickness). Twenty stents were coated with type I collagen and irradiated with a He+ ion beam at an energy of 150 keV with fluences of 1 × 1014 ions/cm2 (ion stent group). Ten stents had no treatment (non-ion stent group). The self-expanding stents were implanted into the right and left peripheral femoral arteries of 15 beagle dogs (vessel diameter approximately 3 mm) via a 6Fr catheter under fluoroscopic guidance. Heparin (100 units/kg) was administered intravenously before implantation. Following stent implantation, no antiplatelet or anticoagulant drugs were administered. The 1-month patency rate for the non-ion stent group was 10% (1/10), and for the ion stent group it was 80% (16/20) with no anticoagulant or antiplatelet drugs given after stent implantation (P = 0.0004 by Fisher's exact test). Ten stents remain patent after 2 years in vivo with no anticoagulant or antiplatelet drugs. These results indicate that He + ion-implanted collagen-coated Ti-Ni self-expanding stents have excellent antithrombogenicity and biocompatibility. This ion stent is promising for coronary and cerebral stent applications.

Original languageEnglish
Pages (from-to)456-463
Number of pages8
JournalArtificial Organs
Issue number6
Publication statusPublished - Jun 2009
Externally publishedYes


  • Cerebral stent
  • Collagen
  • Coronary stent
  • Ion beam surface modification
  • Neointima

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering


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