Abstract
A new antithrombogenic stent using ion beam surface modification nanotechnology was evaluated. The ion stent is being developed to inhibit acute and chronic stent-related thrombosis. Thirty self-expanding mesh stents were fabricated from Ti-Ni metal wires with a dimension of 4 mm (diameter) × 25 mm (length) × 0.15 mm (thickness). Twenty stents were coated with type I collagen and irradiated with a He+ ion beam at an energy of 150 keV with fluences of 1 × 1014 ions/cm2 (ion stent group). Ten stents had no treatment (non-ion stent group). The self-expanding stents were implanted into the right and left peripheral femoral arteries of 15 beagle dogs (vessel diameter approximately 3 mm) via a 6Fr catheter under fluoroscopic guidance. Heparin (100 units/kg) was administered intravenously before implantation. Following stent implantation, no antiplatelet or anticoagulant drugs were administered. The 1-month patency rate for the non-ion stent group was 10% (1/10), and for the ion stent group it was 80% (16/20) with no anticoagulant or antiplatelet drugs given after stent implantation (P = 0.0004 by Fisher's exact test). Ten stents remain patent after 2 years in vivo with no anticoagulant or antiplatelet drugs. These results indicate that He + ion-implanted collagen-coated Ti-Ni self-expanding stents have excellent antithrombogenicity and biocompatibility. This ion stent is promising for coronary and cerebral stent applications.
Original language | English |
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Pages (from-to) | 456-463 |
Number of pages | 8 |
Journal | Artificial Organs |
Volume | 33 |
Issue number | 6 |
DOIs | |
Publication status | Published - Jun 2009 |
Externally published | Yes |
Keywords
- Cerebral stent
- Collagen
- Coronary stent
- Ion beam surface modification
- Neointima
ASJC Scopus subject areas
- Bioengineering
- Medicine (miscellaneous)
- Biomaterials
- Biomedical Engineering