Experimental curative fluorescence-guided surgery of highly invasive glioblastoma multiforme selectively labeled with a killer-reporter adenovirus

Shuuya Yano; Shinji Miwa; Hiroyuki Kishimoto; Makoto Toneri; Yukihiko Hiroshima; Mako Yamamoto; Michael Bouvet; Yasuo Urata; Hiroshi Tazawa; Shunsuke Kagawa; Toshiyoshi Fujiwara; Robert M. Hoffman

doi:10.1038/mt.2015.63

Experimental curative fluorescence-guided surgery of highly invasive glioblastoma multiforme selectively labeled with a killer-reporter adenovirus

Shuuya Yano, Shinji Miwa, Hiroyuki Kishimoto, Makoto Toneri, Yukihiko Hiroshima, Mako Yamamoto, Michael Bouvet, Yasuo Urata, Hiroshi Tazawa, Shunsuke Kagawa, Toshiyoshi Fujiwara, Robert M. Hoffman

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37 Citations (Scopus)

Abstract

Fluorescence-guided surgery (FGS) of cancer is an area of intense current interest. However, although benefits have been demonstrated with FGS, curative strategies need to be developed. Glioblastoma multiforme (GBM) is one of the most invasive of cancers and is not totally resectable using standard bright-light surgery (BLS) or current FGS strategies. We report here a curative strategy for FGS of GBM. In this study, telomerase-dependent adenovirus OBP-401 infection brightly and selectively labeled GBM with green fluorescent protein (GFP) for FGS in orthotopic nude mouse models. OBP-401-based FGS enabled curative resection of GBM without recurrence for at least 150 days, compared to less than 30 days with BLS.

Original language	English
Pages (from-to)	1182-1188
Number of pages	7
Journal	Molecular Therapy
Volume	23
Issue number	7
DOIs	https://doi.org/10.1038/mt.2015.63
Publication status	Published - Jul 1 2015

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Genetics
Pharmacology
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/mt.2015.63

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Yano, S., Miwa, S., Kishimoto, H., Toneri, M., Hiroshima, Y., Yamamoto, M., Bouvet, M., Urata, Y., Tazawa, H., Kagawa, S., Fujiwara, T., & Hoffman, R. M. (2015). Experimental curative fluorescence-guided surgery of highly invasive glioblastoma multiforme selectively labeled with a killer-reporter adenovirus. Molecular Therapy, 23(7), 1182-1188. https://doi.org/10.1038/mt.2015.63

Yano, S, Miwa, S, Kishimoto, H, Toneri, M, Hiroshima, Y, Yamamoto, M, Bouvet, M, Urata, Y, Tazawa, H , Kagawa, S , Fujiwara, T & Hoffman, RM 2015, 'Experimental curative fluorescence-guided surgery of highly invasive glioblastoma multiforme selectively labeled with a killer-reporter adenovirus', Molecular Therapy, vol. 23, no. 7, pp. 1182-1188. https://doi.org/10.1038/mt.2015.63

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title = "Experimental curative fluorescence-guided surgery of highly invasive glioblastoma multiforme selectively labeled with a killer-reporter adenovirus",

abstract = "Fluorescence-guided surgery (FGS) of cancer is an area of intense current interest. However, although benefits have been demonstrated with FGS, curative strategies need to be developed. Glioblastoma multiforme (GBM) is one of the most invasive of cancers and is not totally resectable using standard bright-light surgery (BLS) or current FGS strategies. We report here a curative strategy for FGS of GBM. In this study, telomerase-dependent adenovirus OBP-401 infection brightly and selectively labeled GBM with green fluorescent protein (GFP) for FGS in orthotopic nude mouse models. OBP-401-based FGS enabled curative resection of GBM without recurrence for at least 150 days, compared to less than 30 days with BLS.",

author = "Shuuya Yano and Shinji Miwa and Hiroyuki Kishimoto and Makoto Toneri and Yukihiko Hiroshima and Mako Yamamoto and Michael Bouvet and Yasuo Urata and Hiroshi Tazawa and Shunsuke Kagawa and Toshiyoshi Fujiwara and Hoffman, {Robert M.}",

note = "Funding Information: This paper is dedicated to the memory of A. R. Moossa. This study was supported by grants-in-aid from the Ministry of Education, Science and Culture, Japan, and grants from the Ministry of Health and Welfare, Japan, and supported in part by National Cancer Institute grants CA132971 and CA142669. Publisher Copyright: {\textcopyright} 2015 The American Society of Gene & Cell Therapy.",

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AU - Yano, Shuuya

AU - Miwa, Shinji

AU - Kishimoto, Hiroyuki

AU - Toneri, Makoto

AU - Hiroshima, Yukihiko

AU - Yamamoto, Mako

AU - Bouvet, Michael

AU - Urata, Yasuo

AU - Tazawa, Hiroshi

AU - Kagawa, Shunsuke

AU - Fujiwara, Toshiyoshi

AU - Hoffman, Robert M.

N1 - Funding Information: This paper is dedicated to the memory of A. R. Moossa. This study was supported by grants-in-aid from the Ministry of Education, Science and Culture, Japan, and grants from the Ministry of Health and Welfare, Japan, and supported in part by National Cancer Institute grants CA132971 and CA142669. Publisher Copyright: © 2015 The American Society of Gene & Cell Therapy.

PY - 2015/7/1

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N2 - Fluorescence-guided surgery (FGS) of cancer is an area of intense current interest. However, although benefits have been demonstrated with FGS, curative strategies need to be developed. Glioblastoma multiforme (GBM) is one of the most invasive of cancers and is not totally resectable using standard bright-light surgery (BLS) or current FGS strategies. We report here a curative strategy for FGS of GBM. In this study, telomerase-dependent adenovirus OBP-401 infection brightly and selectively labeled GBM with green fluorescent protein (GFP) for FGS in orthotopic nude mouse models. OBP-401-based FGS enabled curative resection of GBM without recurrence for at least 150 days, compared to less than 30 days with BLS.

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Experimental curative fluorescence-guided surgery of highly invasive glioblastoma multiforme selectively labeled with a killer-reporter adenovirus

Abstract

ASJC Scopus subject areas

UN SDGs

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