Abstract
Fluorescence-guided surgery (FGS) of cancer is an area of intense current interest. However, although benefits have been demonstrated with FGS, curative strategies need to be developed. Glioblastoma multiforme (GBM) is one of the most invasive of cancers and is not totally resectable using standard bright-light surgery (BLS) or current FGS strategies. We report here a curative strategy for FGS of GBM. In this study, telomerase-dependent adenovirus OBP-401 infection brightly and selectively labeled GBM with green fluorescent protein (GFP) for FGS in orthotopic nude mouse models. OBP-401-based FGS enabled curative resection of GBM without recurrence for at least 150 days, compared to less than 30 days with BLS.
| Original language | English |
|---|---|
| Pages (from-to) | 1182-1188 |
| Number of pages | 7 |
| Journal | Molecular Therapy |
| Volume | 23 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 1 2015 |
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ASJC Scopus subject areas
- Molecular Biology
- Molecular Medicine
- Genetics
- Drug Discovery
- Pharmacology
Cite this
Experimental curative fluorescence-guided surgery of highly invasive glioblastoma multiforme selectively labeled with a killer-reporter adenovirus. / Yano, Shuuya; Miwa, Shinji; Kishimoto, Hiroyuki; Toneri, Makoto; Hiroshima, Yukihiko; Yamamoto, Mako; Bouvet, Michael; Urata, Yasuo; Tazawa, Hiroshi; Kagawa, Shunsuke; Fujiwara, Toshiyoshi; Hoffman, Robert M.
In: Molecular Therapy, Vol. 23, No. 7, 01.07.2015, p. 1182-1188.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Experimental curative fluorescence-guided surgery of highly invasive glioblastoma multiforme selectively labeled with a killer-reporter adenovirus
AU - Yano, Shuuya
AU - Miwa, Shinji
AU - Kishimoto, Hiroyuki
AU - Toneri, Makoto
AU - Hiroshima, Yukihiko
AU - Yamamoto, Mako
AU - Bouvet, Michael
AU - Urata, Yasuo
AU - Tazawa, Hiroshi
AU - Kagawa, Shunsuke
AU - Fujiwara, Toshiyoshi
AU - Hoffman, Robert M.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Fluorescence-guided surgery (FGS) of cancer is an area of intense current interest. However, although benefits have been demonstrated with FGS, curative strategies need to be developed. Glioblastoma multiforme (GBM) is one of the most invasive of cancers and is not totally resectable using standard bright-light surgery (BLS) or current FGS strategies. We report here a curative strategy for FGS of GBM. In this study, telomerase-dependent adenovirus OBP-401 infection brightly and selectively labeled GBM with green fluorescent protein (GFP) for FGS in orthotopic nude mouse models. OBP-401-based FGS enabled curative resection of GBM without recurrence for at least 150 days, compared to less than 30 days with BLS.
AB - Fluorescence-guided surgery (FGS) of cancer is an area of intense current interest. However, although benefits have been demonstrated with FGS, curative strategies need to be developed. Glioblastoma multiforme (GBM) is one of the most invasive of cancers and is not totally resectable using standard bright-light surgery (BLS) or current FGS strategies. We report here a curative strategy for FGS of GBM. In this study, telomerase-dependent adenovirus OBP-401 infection brightly and selectively labeled GBM with green fluorescent protein (GFP) for FGS in orthotopic nude mouse models. OBP-401-based FGS enabled curative resection of GBM without recurrence for at least 150 days, compared to less than 30 days with BLS.
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UR - http://www.scopus.com/inward/citedby.url?scp=84934444477&partnerID=8YFLogxK
U2 - 10.1038/mt.2015.63
DO - 10.1038/mt.2015.63
M3 - Article
VL - 23
SP - 1182
EP - 1188
JO - Molecular Therapy
JF - Molecular Therapy
SN - 1525-0016
IS - 7
ER -