Experimental curative fluorescence-guided surgery of highly invasive glioblastoma multiforme selectively labeled with a killer-reporter adenovirus

Shuya Yano; Shinji Miwa; Hiroyuki Kishimoto; Makoto Toneri; Yukihiko Hiroshima; Mako Yamamoto; Michael Bouvet; Yasuo Urata; Hiroshi Tazawa; Shunsuke Kagawa; Toshiyoshi Fujiwara; Robert M. Hoffman

doi:10.1038/mt.2015.63

Experimental curative fluorescence-guided surgery of highly invasive glioblastoma multiforme selectively labeled with a killer-reporter adenovirus

Shuya Yano, Shinji Miwa, Hiroyuki Kishimoto, Makoto Toneri, Yukihiko Hiroshima, Mako Yamamoto, Michael Bouvet, Yasuo Urata, Hiroshi Tazawa, Shunsuke Kagawa, Toshiyoshi Fujiwara, Robert M. Hoffman

Research output: Contribution to journal › Article

32 Citations (Scopus)

Abstract

Fluorescence-guided surgery (FGS) of cancer is an area of intense current interest. However, although benefits have been demonstrated with FGS, curative strategies need to be developed. Glioblastoma multiforme (GBM) is one of the most invasive of cancers and is not totally resectable using standard bright-light surgery (BLS) or current FGS strategies. We report here a curative strategy for FGS of GBM. In this study, telomerase-dependent adenovirus OBP-401 infection brightly and selectively labeled GBM with green fluorescent protein (GFP) for FGS in orthotopic nude mouse models. OBP-401-based FGS enabled curative resection of GBM without recurrence for at least 150 days, compared to less than 30 days with BLS.

Original language	English
Pages (from-to)	1182-1188
Number of pages	7
Journal	Molecular Therapy
Volume	23
Issue number	7
DOIs	https://doi.org/10.1038/mt.2015.63
Publication status	Published - Jul 1 2015

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ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Genetics
Pharmacology
Drug Discovery

Cite this

Yano, S., Miwa, S., Kishimoto, H., Toneri, M., Hiroshima, Y., Yamamoto, M., Bouvet, M., Urata, Y., Tazawa, H., Kagawa, S., Fujiwara, T., & Hoffman, R. M. (2015). Experimental curative fluorescence-guided surgery of highly invasive glioblastoma multiforme selectively labeled with a killer-reporter adenovirus. Molecular Therapy, 23(7), 1182-1188. https://doi.org/10.1038/mt.2015.63

Experimental curative fluorescence-guided surgery of highly invasive glioblastoma multiforme selectively labeled with a killer-reporter adenovirus. / Yano, Shuya; Miwa, Shinji; Kishimoto, Hiroyuki; Toneri, Makoto; Hiroshima, Yukihiko; Yamamoto, Mako; Bouvet, Michael; Urata, Yasuo; Tazawa, Hiroshi ; Kagawa, Shunsuke ; Fujiwara, Toshiyoshi; Hoffman, Robert M.

In: Molecular Therapy, Vol. 23, No. 7, 01.07.2015, p. 1182-1188.

Research output: Contribution to journal › Article

Yano, S, Miwa, S, Kishimoto, H, Toneri, M, Hiroshima, Y, Yamamoto, M, Bouvet, M, Urata, Y, Tazawa, H , Kagawa, S , Fujiwara, T & Hoffman, RM 2015, 'Experimental curative fluorescence-guided surgery of highly invasive glioblastoma multiforme selectively labeled with a killer-reporter adenovirus', Molecular Therapy, vol. 23, no. 7, pp. 1182-1188. https://doi.org/10.1038/mt.2015.63

Yano, Shuya ; Miwa, Shinji ; Kishimoto, Hiroyuki ; Toneri, Makoto ; Hiroshima, Yukihiko ; Yamamoto, Mako ; Bouvet, Michael ; Urata, Yasuo ; Tazawa, Hiroshi ; Kagawa, Shunsuke ; Fujiwara, Toshiyoshi ; Hoffman, Robert M. / Experimental curative fluorescence-guided surgery of highly invasive glioblastoma multiforme selectively labeled with a killer-reporter adenovirus. In: Molecular Therapy. 2015 ; Vol. 23, No. 7. pp. 1182-1188.

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10.1038/mt.2015.63