Experimental curative fluorescence-guided surgery of highly invasive glioblastoma multiforme selectively labeled with a killer-reporter adenovirus

Shuuya Yano, Shinji Miwa, Hiroyuki Kishimoto, Makoto Toneri, Yukihiko Hiroshima, Mako Yamamoto, Michael Bouvet, Yasuo Urata, Hiroshi Tazawa, Shunsuke Kagawa, Toshiyoshi Fujiwara, Robert M. Hoffman

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Fluorescence-guided surgery (FGS) of cancer is an area of intense current interest. However, although benefits have been demonstrated with FGS, curative strategies need to be developed. Glioblastoma multiforme (GBM) is one of the most invasive of cancers and is not totally resectable using standard bright-light surgery (BLS) or current FGS strategies. We report here a curative strategy for FGS of GBM. In this study, telomerase-dependent adenovirus OBP-401 infection brightly and selectively labeled GBM with green fluorescent protein (GFP) for FGS in orthotopic nude mouse models. OBP-401-based FGS enabled curative resection of GBM without recurrence for at least 150 days, compared to less than 30 days with BLS.

Original languageEnglish
Pages (from-to)1182-1188
Number of pages7
JournalMolecular Therapy
Volume23
Issue number7
DOIs
Publication statusPublished - Jul 1 2015

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Glioblastoma
Adenoviridae
Fluorescence
Light
Telomerase
Green Fluorescent Proteins
Nude Mice
Neoplasms
Recurrence
Infection

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine
  • Genetics
  • Drug Discovery
  • Pharmacology

Cite this

Experimental curative fluorescence-guided surgery of highly invasive glioblastoma multiforme selectively labeled with a killer-reporter adenovirus. / Yano, Shuuya; Miwa, Shinji; Kishimoto, Hiroyuki; Toneri, Makoto; Hiroshima, Yukihiko; Yamamoto, Mako; Bouvet, Michael; Urata, Yasuo; Tazawa, Hiroshi; Kagawa, Shunsuke; Fujiwara, Toshiyoshi; Hoffman, Robert M.

In: Molecular Therapy, Vol. 23, No. 7, 01.07.2015, p. 1182-1188.

Research output: Contribution to journalArticle

Yano, Shuuya ; Miwa, Shinji ; Kishimoto, Hiroyuki ; Toneri, Makoto ; Hiroshima, Yukihiko ; Yamamoto, Mako ; Bouvet, Michael ; Urata, Yasuo ; Tazawa, Hiroshi ; Kagawa, Shunsuke ; Fujiwara, Toshiyoshi ; Hoffman, Robert M. / Experimental curative fluorescence-guided surgery of highly invasive glioblastoma multiforme selectively labeled with a killer-reporter adenovirus. In: Molecular Therapy. 2015 ; Vol. 23, No. 7. pp. 1182-1188.
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