Experimental allergic conjunctivitis in guinea pigs induced by Japanese cedar pollen

Miho Takada, Tamao Yamada, Hiroto Nakahara, Yukio Sugimoto, Keiji Izushi, Chiaki Kamei

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We report a new experimental allergic conjunctivitis with Japanese cedar pollen as antigen in guinea pigs, and the immunological characteristics of this model were also elucidated. Allergic conjunctivitis was developed by immunization in guinea pigs with a mixture containing Japanese cedar pollen and killed Bordetella pertussis. When local application of Japanese cedar pollen suspension 14 d after systemic immunization was performed every 3 d, remarkable conjunctivitis was observed from 20 to 35d. Increase in vascular permeability and decrease in histamine contents of the conjunctiva were also observed after local application of antigen. Passive cutaneous anaphylactic (PCA) reactions revealed that both IgG- and IgE-rich antibodies were produced in this model. Chlorpheniramine, ketotifen and levocabastine were effective in inhibiting cedar pollen-induced conjunctivitis. Although a high concentration was needed, tranilast and amlexanox also showed significant inhibition of conjunctivitis induced by cedar pollen.

Original languageEnglish
Pages (from-to)566-569
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Volume23
Issue number5
DOIs
Publication statusPublished - May 2000

Keywords

  • Allergic conjunctivitis
  • Amlexanox
  • Chlorpheniramine
  • IgG antibody
  • Japanese cedar pollen
  • Ketotifen

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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