Existence of a Novel Hemagglutinin Having No Protease Activity in Vibrio mimicus

Munirul Alam, Shin Ichi Miyoshi, Ikuyo Maruo, Chiemi Ogawa, Sumio Shinoda

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The protease elaborated by Vibrio mimicus is known to possess hemagglutinating ability to chicken erythrocytes, the well-known HA/protease. A non-protease hemagglutinin (HA) with strong agglutinating ability towards rabbit erythrocytes was obtained from 32 hr culture supernatant of a pathogenic environmental strain of V. mimicus. This HA (V. mimicus HA: VMHA) appeared stable at relatively higher temperature and agglutinated the erythrocytes from rabbit, guinea pig and mouse but not the erythrocytes from chicken, bovine, horse and sheep. Simple sugars, metal ions and chelating agents failed to inhibit the activity of VMHA. The activity of VMHA was found to be sensitive to digestion by proteolytic enzymes including HA/protease. These results provide evidence for the existence of novel HA other than HA/protease in V. mimicus.

Original languageEnglish
Pages (from-to)467-470
Number of pages4
JournalMICROBIOLOGY and IMMUNOLOGY
Volume38
Issue number6
DOIs
Publication statusPublished - Jan 1 1994

Keywords

  • HA/protease
  • Hemagglutinin
  • Vibrio mimicus

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology

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