TY - JOUR
T1 - Excretion of 3,3′,4,4′,5-pentachlorobiphenyl (PCB126) from rat liver following oral administration of Lactobacillus reuteri and Lactobacillus acidophilus
AU - Suzuki, Takehito
AU - Yamazaki, Kaoru
AU - Shinoda, Tadashi
AU - Shirai, Mitsuyuki
AU - Yoshikawa, Hiroshi
AU - Noguchi, Yurika
AU - Ito, Tetsuro
AU - Shii, Yasuoi
AU - Takizawa, Tatsuya
AU - Morita, Hidetoshi
N1 - Publisher Copyright:
Copyright © 2014, Japanese Society for Food Science and Technology.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2014
Y1 - 2014
N2 - Oral administration of Lactobacillus reuteri CP3012 or Lactobacillus acidophilus L-92 for 60 days in rats that were previously administered 3,3′,4,4′,5-pentachlorobiphenyl (PCB126) orally at a dose of 100 μg/kg of body weight resulted in a significant decrease in hepatic bioaccumulation of PCB126 (p < 0.05), with levels of 30.7 ± 3.7 ng/g and 92.6 ± 25.0 ng/g of liver tissue, respectively, compared with 133.1 ± 12.7 ng/g of liver tissue in the controls. The electron paramagnetic resonance signal level of the liver PCB126-specific g = 2.49 species in rats administered L. reuteri CP3012 decreased significantly (p < 0.05). Both the bile acid concentration in the feces and total stool output increased significantly following administration of lactobacilli (p < 0.05); however, adsorption of PCB126 onto the bacterial cells was not observed. These results suggest that these bacteria inhibit reabsorption of PCB126 with bile acid by blocking enterohepatic circulation through absorbing and/or deconjugating the bile acids in the intestinal tract and by promoting excretion of bile acids from the body, thus reducing PCB126 accumulation in the liver.
AB - Oral administration of Lactobacillus reuteri CP3012 or Lactobacillus acidophilus L-92 for 60 days in rats that were previously administered 3,3′,4,4′,5-pentachlorobiphenyl (PCB126) orally at a dose of 100 μg/kg of body weight resulted in a significant decrease in hepatic bioaccumulation of PCB126 (p < 0.05), with levels of 30.7 ± 3.7 ng/g and 92.6 ± 25.0 ng/g of liver tissue, respectively, compared with 133.1 ± 12.7 ng/g of liver tissue in the controls. The electron paramagnetic resonance signal level of the liver PCB126-specific g = 2.49 species in rats administered L. reuteri CP3012 decreased significantly (p < 0.05). Both the bile acid concentration in the feces and total stool output increased significantly following administration of lactobacilli (p < 0.05); however, adsorption of PCB126 onto the bacterial cells was not observed. These results suggest that these bacteria inhibit reabsorption of PCB126 with bile acid by blocking enterohepatic circulation through absorbing and/or deconjugating the bile acids in the intestinal tract and by promoting excretion of bile acids from the body, thus reducing PCB126 accumulation in the liver.
KW - Enterohepatic circulation
KW - Lactobacillus acidophilus
KW - Lactobacillus reuteri
KW - PCB126
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U2 - 10.3136/fstr.20.821
DO - 10.3136/fstr.20.821
M3 - Article
AN - SCOPUS:84908876824
VL - 20
SP - 821
EP - 828
JO - Food Science and Technology Research
JF - Food Science and Technology Research
SN - 1344-6606
IS - 4
ER -