Excretion of 3,3′,4,4′,5-pentachlorobiphenyl (PCB126) from rat liver following oral administration of Lactobacillus reuteri and Lactobacillus acidophilus

Takehito Suzuki, Kaoru Yamazaki, Tadashi Shinoda, Mitsuyuki Shirai, Hiroshi Yoshikawa, Yurika Noguchi, Tetsuro Ito, Yasuoi Shii, Tatsuya Takizawa, Hidetoshi Morita

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Oral administration of Lactobacillus reuteri CP3012 or Lactobacillus acidophilus L-92 for 60 days in rats that were previously administered 3,3′,4,4′,5-pentachlorobiphenyl (PCB126) orally at a dose of 100 μg/kg of body weight resulted in a significant decrease in hepatic bioaccumulation of PCB126 (p < 0.05), with levels of 30.7 ± 3.7 ng/g and 92.6 ± 25.0 ng/g of liver tissue, respectively, compared with 133.1 ± 12.7 ng/g of liver tissue in the controls. The electron paramagnetic resonance signal level of the liver PCB126-specific g = 2.49 species in rats administered L. reuteri CP3012 decreased significantly (p < 0.05). Both the bile acid concentration in the feces and total stool output increased significantly following administration of lactobacilli (p < 0.05); however, adsorption of PCB126 onto the bacterial cells was not observed. These results suggest that these bacteria inhibit reabsorption of PCB126 with bile acid by blocking enterohepatic circulation through absorbing and/or deconjugating the bile acids in the intestinal tract and by promoting excretion of bile acids from the body, thus reducing PCB126 accumulation in the liver.

Original languageEnglish
Pages (from-to)821-828
Number of pages8
JournalFood Science and Technology Research
Volume20
Issue number4
DOIs
Publication statusPublished - Jan 1 2014
Externally publishedYes

Keywords

  • Enterohepatic circulation
  • Lactobacillus acidophilus
  • Lactobacillus reuteri
  • PCB126

ASJC Scopus subject areas

  • Biotechnology
  • Food Science
  • Chemical Engineering(all)
  • Industrial and Manufacturing Engineering
  • Marketing

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