Exchange transfusion and cytarabine for transient abnormal myelopoiesis in hydrops fetalis

Tomoka Okamura; Yousuke Washio; Junko Yoshimoto; Kazumasa Tani; Hirokazu Tsukahara; Akira Shimada

Exchange transfusion and cytarabine for transient abnormal myelopoiesis in hydrops fetalis

Tomoka Okamura, Yousuke Washio, Junko Yoshimoto, Kazumasa Tani, Hirokazu Tsukahara, Akira Shimada

Research output: Contribution to journal › Article › peer-review

Abstract

Most cases of transient abnormal myelopoiesis (TAM) in neonates with Down syndrome (DS) resolve spontaneously; however, DS-TAM neonates with hydrops fetalis (HF) show poor clinical outcomes. We report three infants with DS-TAM and HF who were treated with exchange transfusion (ET) followed by low-dose cytarabine (LD-CA). All of them survived without developing liver failure, acute leukemia, or other serious adverse events. Our results suggest that this combination treatment with ET and LD-CA would be safe, tolerable and effective as an novel approach for DS-TAM patients with HF.

Original language	English
Pages (from-to)	181-188
Number of pages	8
Journal	Acta medica Okayama
Volume	73
Issue number	2
Publication status	Published - 2019

Keywords

Cytarabine
Down syndrome
Exchange transfusion
Hydrops fetalis
Transient abnormal myelopoiesis

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Cite this

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title = "Exchange transfusion and cytarabine for transient abnormal myelopoiesis in hydrops fetalis",

abstract = "Most cases of transient abnormal myelopoiesis (TAM) in neonates with Down syndrome (DS) resolve spontaneously; however, DS-TAM neonates with hydrops fetalis (HF) show poor clinical outcomes. We report three infants with DS-TAM and HF who were treated with exchange transfusion (ET) followed by low-dose cytarabine (LD-CA). All of them survived without developing liver failure, acute leukemia, or other serious adverse events. Our results suggest that this combination treatment with ET and LD-CA would be safe, tolerable and effective as an novel approach for DS-TAM patients with HF.",

keywords = "Cytarabine, Down syndrome, Exchange transfusion, Hydrops fetalis, Transient abnormal myelopoiesis",

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T1 - Exchange transfusion and cytarabine for transient abnormal myelopoiesis in hydrops fetalis

AU - Okamura, Tomoka

AU - Washio, Yousuke

AU - Yoshimoto, Junko

AU - Tani, Kazumasa

AU - Tsukahara, Hirokazu

AU - Shimada, Akira

PY - 2019

Y1 - 2019

N2 - Most cases of transient abnormal myelopoiesis (TAM) in neonates with Down syndrome (DS) resolve spontaneously; however, DS-TAM neonates with hydrops fetalis (HF) show poor clinical outcomes. We report three infants with DS-TAM and HF who were treated with exchange transfusion (ET) followed by low-dose cytarabine (LD-CA). All of them survived without developing liver failure, acute leukemia, or other serious adverse events. Our results suggest that this combination treatment with ET and LD-CA would be safe, tolerable and effective as an novel approach for DS-TAM patients with HF.

AB - Most cases of transient abnormal myelopoiesis (TAM) in neonates with Down syndrome (DS) resolve spontaneously; however, DS-TAM neonates with hydrops fetalis (HF) show poor clinical outcomes. We report three infants with DS-TAM and HF who were treated with exchange transfusion (ET) followed by low-dose cytarabine (LD-CA). All of them survived without developing liver failure, acute leukemia, or other serious adverse events. Our results suggest that this combination treatment with ET and LD-CA would be safe, tolerable and effective as an novel approach for DS-TAM patients with HF.

KW - Cytarabine

KW - Down syndrome

KW - Exchange transfusion

KW - Hydrops fetalis

KW - Transient abnormal myelopoiesis

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Exchange transfusion and cytarabine for transient abnormal myelopoiesis in hydrops fetalis

Abstract

Keywords

ASJC Scopus subject areas

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