Exchange of dominant lymphoid cell clones in a patient with adult T-cell leukemia/lymphoma

K. Iwatsuki, F. Inoue, M. Takigawa, G. Iemoto, T. Nagatani, H. Nakajima, M. Yamada

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We performed a genotypic study on lymphoid cells from a patient with adult T-cell leukemia (ATL). Clonal proliferation of human lymphotropic virus type-1 (HTLV-1)-infected helper T-cells was detected in the primary skin tumors, while no clonality of the virus-infected lymphocytes was observed in the peripheral blood. Following intensive chemotherapy, however, we detected the presence of two genotypically different HTLV-1-infected lymphocyte clones in different samples taken from the peripheral blood. These data demonstrated the exchange of the dominant neoplastic clone in the clinical course of ATL, suggesting the possibility that a certain clone among many repertoires of HTLV-1-infected T-cells has a capability of leukemogenesis, instead of the primary tumour cells.

Original languageEnglish
Pages (from-to)49-52
Number of pages4
JournalActa Dermato-Venereologica
Volume70
Issue number1
Publication statusPublished - 1990
Externally publishedYes

Fingerprint

Adult T Cell Leukemia Lymphoma
Human T-lymphotropic virus 1
Clone Cells
Lymphocytes
Viruses
Helper-Inducer T-Lymphocytes
Neoplasms
T-Lymphocytes
Drug Therapy
Skin

Keywords

  • clonality
  • genotypic analysis
  • human T-cell lymphotropic virus type 1

ASJC Scopus subject areas

  • Dermatology

Cite this

Iwatsuki, K., Inoue, F., Takigawa, M., Iemoto, G., Nagatani, T., Nakajima, H., & Yamada, M. (1990). Exchange of dominant lymphoid cell clones in a patient with adult T-cell leukemia/lymphoma. Acta Dermato-Venereologica, 70(1), 49-52.

Exchange of dominant lymphoid cell clones in a patient with adult T-cell leukemia/lymphoma. / Iwatsuki, K.; Inoue, F.; Takigawa, M.; Iemoto, G.; Nagatani, T.; Nakajima, H.; Yamada, M.

In: Acta Dermato-Venereologica, Vol. 70, No. 1, 1990, p. 49-52.

Research output: Contribution to journalArticle

Iwatsuki, K, Inoue, F, Takigawa, M, Iemoto, G, Nagatani, T, Nakajima, H & Yamada, M 1990, 'Exchange of dominant lymphoid cell clones in a patient with adult T-cell leukemia/lymphoma', Acta Dermato-Venereologica, vol. 70, no. 1, pp. 49-52.
Iwatsuki K, Inoue F, Takigawa M, Iemoto G, Nagatani T, Nakajima H et al. Exchange of dominant lymphoid cell clones in a patient with adult T-cell leukemia/lymphoma. Acta Dermato-Venereologica. 1990;70(1):49-52.
Iwatsuki, K. ; Inoue, F. ; Takigawa, M. ; Iemoto, G. ; Nagatani, T. ; Nakajima, H. ; Yamada, M. / Exchange of dominant lymphoid cell clones in a patient with adult T-cell leukemia/lymphoma. In: Acta Dermato-Venereologica. 1990 ; Vol. 70, No. 1. pp. 49-52.
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