Examination of an inhibitory effect on the immunoglobulin E production by Th2 cytokine inhibitor on atopic dermatitis

Shun Kitaba, Shigeki Inui, Ichiro Katayama, Yoshinari Matsumoto, Yumi Matsumura, Yoshiki Miyachi, Akiko Kishioka, Fukumi Furukawa, Yasuo Kubota, Gen Nakanishi, Keiji Iwatsuki, Sakae Kaneko, Eishin Morita, Kunio Izu, Yoshiki Tokura, Shuji Fukagawa, Masutaka Furue, Motoi Takenaka, Shinichi Sato, Kazumoto Katagiri

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Abstract

We investigated the effects of oral Suplatast tosilate(IPD), the selective Th2 cytokine suppressor, on adult atopic dermatitis(AD). We divided the patients into two groups; (1)IPD+topical ointment (IPD group) and (2) antiallergic drug+topical ointment or topical ointment alone (control groups), and evaluated skin symptoms, serum immunoglobulin E level, LDH level, and the number of eosinophils and basophils. Although there were no significant improvement of laboratory data, skin symptoms improved in both groups. Especially in high value of immunoglobulin E and basophils patients, the IPD group showed significant improvement of skin symptoms compared with the control group. Therefore, we suggest that IPD may be more effective to the patients with high value of immunoglobulin E and basophils.

Original languageEnglish
Pages (from-to)8-14
Number of pages7
JournalSkin Research
Volume6
Issue numberSUPPL. 8
Publication statusPublished - Mar 2007

Keywords

  • Atopic dermatitis
  • Immunoglobulin E
  • Suplatast tosilate

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

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  • Cite this

    Kitaba, S., Inui, S., Katayama, I., Matsumoto, Y., Matsumura, Y., Miyachi, Y., Kishioka, A., Furukawa, F., Kubota, Y., Nakanishi, G., Iwatsuki, K., Kaneko, S., Morita, E., Izu, K., Tokura, Y., Fukagawa, S., Furue, M., Takenaka, M., Sato, S., & Katagiri, K. (2007). Examination of an inhibitory effect on the immunoglobulin E production by Th2 cytokine inhibitor on atopic dermatitis. Skin Research, 6(SUPPL. 8), 8-14.