Ex vivo gene therapy: Transplantation of neurotrophic factor-secreting cells for cerebral ischemia

Takao Yasuhara, Cesario V. Borlongan, Isao Date

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Expressions of various neurotrophic factors or their receptors fluctuate after stroke, which in part prompted investigations into the efficacy of neurotrophic factors as treatment modality for stroke. The methods to deliver neurotrophic factors into the brain can be categorized into: 1) the surgical route of administration, such as intracerebral, intraventricular, intra-arterial, or intravenous systemic administration and 2) the manipulation of the therapeutic molecules via ex vivo or in vivo techniques. With ex vivo method, genetically engineered cells, including the use of autologous cells, have been explored. In this review, the potent therapeutic applications of neurotrophic factors in stroke are described, with emphasis on ex vivo methods, especially transplantation of encapsulated stem cells modified with adenovirus. Neurotrophic factor delivery, combined with ex vivo method, poses as novel treatment for stroke, although additional safety and efficacy studies remain to be examined.

Original languageEnglish
Pages (from-to)760-775
Number of pages16
JournalFrontiers in Bioscience
Volume11
Issue number1 P.447-888
DOIs
Publication statusPublished - 2006

Keywords

  • BDNF
  • Brain
  • Cytokine
  • Encapsulation
  • GDNF
  • Gene therapy
  • Nervous system
  • Neurotrophic factor
  • Review
  • Stem cell
  • Stroke
  • Therapeutics
  • Treatment
  • VEGF
  • ex vivo

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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