Evolutionary history of the calcitonin gene-related peptide family in vertebrates revealed by comparative genomic analyses

Maho Ogoshi, Koji Inoue, Kiyoshi Naruse, Yoshio Takei

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

The calcitonin gene-related peptide (CGRP) family is composed of CGRP, amylin and adrenomedullin (AM) in mammals. In teleost fish, AM forms an independent subfamily of five members (AM1-5), which inspired us to trace the evolutionary history of the CGRP family throughout vertebrates by comparative genomic approach. Linkage mapping and synteny analyses of the CGRP family genes in medaka, Oryzias latipes, revealed that AM1/CGRP, AM2/amylin, and AM5 genes were located on respective proto-chromosomes before the divergence of teleost lineage. In teleost fish, additional whole genome duplication generated AM1/4, CGRP1/2, AM2/3, but one of the duplicated amylin and AM5 genes was silenced. In mammals, the amylin or AM2 gene was translocated to different chromosomes, while the CGRP gene was multiplied in tandem to generate CGRP-α,β, and recently identified calcitonin receptor-stimulating peptide genes. Based on these data, we identified a novel AM5 gene in several mammalian species as we previously did for AM2.

Original languageEnglish
Pages (from-to)3154-3164
Number of pages11
JournalPeptides
Volume27
Issue number12
DOIs
Publication statusPublished - Dec 1 2006
Externally publishedYes

Keywords

  • Adrenomedullin
  • Amylin
  • CGRP
  • Linkage analyses
  • Molecular evolution

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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