TY - JOUR
T1 - Evolutionary history of the calcitonin gene-related peptide family in vertebrates revealed by comparative genomic analyses
AU - Ogoshi, Maho
AU - Inoue, Koji
AU - Naruse, Kiyoshi
AU - Takei, Yoshio
N1 - Funding Information:
We thank Dr. Naoto Minamino (National Cardiovascular Center Research Institute), Dr. Hideo Bannai (Kyushu University) and Dr. Satoru Miyano (Institute of Medical Science, University of Tokyo) for valuable discussion. We also thank Dr. Jorge M.O. Fernandes (University of St. Andrews) for his critical reading of the manuscript. This work was supported by Grant-in-Aid for Scientific Research (16207004) from the Japan Society for the Promotion of Science to Y.T. and by a Research Fellowship from the Japan Society for the Promotion of Science for young scientists to M.O.
PY - 2006/12
Y1 - 2006/12
N2 - The calcitonin gene-related peptide (CGRP) family is composed of CGRP, amylin and adrenomedullin (AM) in mammals. In teleost fish, AM forms an independent subfamily of five members (AM1-5), which inspired us to trace the evolutionary history of the CGRP family throughout vertebrates by comparative genomic approach. Linkage mapping and synteny analyses of the CGRP family genes in medaka, Oryzias latipes, revealed that AM1/CGRP, AM2/amylin, and AM5 genes were located on respective proto-chromosomes before the divergence of teleost lineage. In teleost fish, additional whole genome duplication generated AM1/4, CGRP1/2, AM2/3, but one of the duplicated amylin and AM5 genes was silenced. In mammals, the amylin or AM2 gene was translocated to different chromosomes, while the CGRP gene was multiplied in tandem to generate CGRP-α,β, and recently identified calcitonin receptor-stimulating peptide genes. Based on these data, we identified a novel AM5 gene in several mammalian species as we previously did for AM2.
AB - The calcitonin gene-related peptide (CGRP) family is composed of CGRP, amylin and adrenomedullin (AM) in mammals. In teleost fish, AM forms an independent subfamily of five members (AM1-5), which inspired us to trace the evolutionary history of the CGRP family throughout vertebrates by comparative genomic approach. Linkage mapping and synteny analyses of the CGRP family genes in medaka, Oryzias latipes, revealed that AM1/CGRP, AM2/amylin, and AM5 genes were located on respective proto-chromosomes before the divergence of teleost lineage. In teleost fish, additional whole genome duplication generated AM1/4, CGRP1/2, AM2/3, but one of the duplicated amylin and AM5 genes was silenced. In mammals, the amylin or AM2 gene was translocated to different chromosomes, while the CGRP gene was multiplied in tandem to generate CGRP-α,β, and recently identified calcitonin receptor-stimulating peptide genes. Based on these data, we identified a novel AM5 gene in several mammalian species as we previously did for AM2.
KW - Adrenomedullin
KW - Amylin
KW - CGRP
KW - Linkage analyses
KW - Molecular evolution
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U2 - 10.1016/j.peptides.2006.09.011
DO - 10.1016/j.peptides.2006.09.011
M3 - Article
C2 - 17092606
AN - SCOPUS:33750958474
SN - 0196-9781
VL - 27
SP - 3154
EP - 3164
JO - Peptides
JF - Peptides
IS - 12
ER -