Evolution of mammalian Opn5 as a specialized UV-absorbing pigment by a single amino acid mutation

Takahiro Yamashita, Katsuhiko Ono, Hideyo Ohuchi, Akane Yumoto, Hitoshi Gotoh, Sayuri Tomonari, Kazumi Sakai, Hirofumi Fujita, Yasushi Imamoto, Sumihare Noji, Katsuki Nakamura, Yoshinori Shichida

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background: Opn5 is considered to regulate nonvisual photoreception in the retina and brain of animals. Results: Mouse and primate UV-sensitive Opn5 along with retinoid isomerase are localized in the preoptic hypothalamus. Conclusion: Mammalian Opn5 can function as a high sensitivity photosensor in the deep brain with the assistance of 11-cisretinal supplying system. Significance: Mammals, including humans, may detect short wavelength light within the brain via Opn5.

Original languageEnglish
Pages (from-to)3991-4000
Number of pages10
JournalJournal of Biological Chemistry
Volume289
Issue number7
DOIs
Publication statusPublished - Feb 14 2014

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Pigments
Brain
Amino Acids
Mutation
Mammals
Primates
Hypothalamus
Retina
Animals
Light
Wavelength
retinoid isomerohydrolase

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Evolution of mammalian Opn5 as a specialized UV-absorbing pigment by a single amino acid mutation. / Yamashita, Takahiro; Ono, Katsuhiko; Ohuchi, Hideyo; Yumoto, Akane; Gotoh, Hitoshi; Tomonari, Sayuri; Sakai, Kazumi; Fujita, Hirofumi; Imamoto, Yasushi; Noji, Sumihare; Nakamura, Katsuki; Shichida, Yoshinori.

In: Journal of Biological Chemistry, Vol. 289, No. 7, 14.02.2014, p. 3991-4000.

Research output: Contribution to journalArticle

Yamashita, T, Ono, K, Ohuchi, H, Yumoto, A, Gotoh, H, Tomonari, S, Sakai, K, Fujita, H, Imamoto, Y, Noji, S, Nakamura, K & Shichida, Y 2014, 'Evolution of mammalian Opn5 as a specialized UV-absorbing pigment by a single amino acid mutation', Journal of Biological Chemistry, vol. 289, no. 7, pp. 3991-4000. https://doi.org/10.1074/jbc.M113.514075
Yamashita, Takahiro ; Ono, Katsuhiko ; Ohuchi, Hideyo ; Yumoto, Akane ; Gotoh, Hitoshi ; Tomonari, Sayuri ; Sakai, Kazumi ; Fujita, Hirofumi ; Imamoto, Yasushi ; Noji, Sumihare ; Nakamura, Katsuki ; Shichida, Yoshinori. / Evolution of mammalian Opn5 as a specialized UV-absorbing pigment by a single amino acid mutation. In: Journal of Biological Chemistry. 2014 ; Vol. 289, No. 7. pp. 3991-4000.
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