Evolution of mammalian Opn5 as a specialized UV-absorbing pigment by a single amino acid mutation

Takahiro Yamashita; Katsuhiko Ono; Hideyo Ohuchi; Akane Yumoto; Hitoshi Gotoh; Sayuri Tomonari; Kazumi Sakai; Hirofumi Fujita; Yasushi Imamoto; Sumihare Noji; Katsuki Nakamura; Yoshinori Shichida

doi:10.1074/jbc.M113.514075

Evolution of mammalian Opn5 as a specialized UV-absorbing pigment by a single amino acid mutation

Takahiro Yamashita, Katsuhiko Ono, Hideyo Ohuchi, Akane Yumoto, Hitoshi Gotoh, Sayuri Tomonari, Kazumi Sakai, Hirofumi Fujita, Yasushi Imamoto, Sumihare Noji, Katsuki Nakamura, Yoshinori Shichida

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Background: Opn5 is considered to regulate nonvisual photoreception in the retina and brain of animals. Results: Mouse and primate UV-sensitive Opn5 along with retinoid isomerase are localized in the preoptic hypothalamus. Conclusion: Mammalian Opn5 can function as a high sensitivity photosensor in the deep brain with the assistance of 11-cisretinal supplying system. Significance: Mammals, including humans, may detect short wavelength light within the brain via Opn5.

Original language	English
Pages (from-to)	3991-4000
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	289
Issue number	7
DOIs	https://doi.org/10.1074/jbc.M113.514075
Publication status	Published - Feb 14 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "Evolution of mammalian Opn5 as a specialized UV-absorbing pigment by a single amino acid mutation",

abstract = "Background: Opn5 is considered to regulate nonvisual photoreception in the retina and brain of animals. Results: Mouse and primate UV-sensitive Opn5 along with retinoid isomerase are localized in the preoptic hypothalamus. Conclusion: Mammalian Opn5 can function as a high sensitivity photosensor in the deep brain with the assistance of 11-cisretinal supplying system. Significance: Mammals, including humans, may detect short wavelength light within the brain via Opn5.",

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T1 - Evolution of mammalian Opn5 as a specialized UV-absorbing pigment by a single amino acid mutation

AU - Yamashita, Takahiro

AU - Ono, Katsuhiko

AU - Ohuchi, Hideyo

AU - Yumoto, Akane

AU - Gotoh, Hitoshi

AU - Tomonari, Sayuri

AU - Sakai, Kazumi

AU - Fujita, Hirofumi

AU - Imamoto, Yasushi

AU - Noji, Sumihare

AU - Nakamura, Katsuki

AU - Shichida, Yoshinori

PY - 2014/2/14

Y1 - 2014/2/14

N2 - Background: Opn5 is considered to regulate nonvisual photoreception in the retina and brain of animals. Results: Mouse and primate UV-sensitive Opn5 along with retinoid isomerase are localized in the preoptic hypothalamus. Conclusion: Mammalian Opn5 can function as a high sensitivity photosensor in the deep brain with the assistance of 11-cisretinal supplying system. Significance: Mammals, including humans, may detect short wavelength light within the brain via Opn5.

AB - Background: Opn5 is considered to regulate nonvisual photoreception in the retina and brain of animals. Results: Mouse and primate UV-sensitive Opn5 along with retinoid isomerase are localized in the preoptic hypothalamus. Conclusion: Mammalian Opn5 can function as a high sensitivity photosensor in the deep brain with the assistance of 11-cisretinal supplying system. Significance: Mammals, including humans, may detect short wavelength light within the brain via Opn5.

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Evolution of mammalian Opn5 as a specialized UV-absorbing pigment by a single amino acid mutation

Abstract

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