Evidence that CD8+ dendritic cells enable the development of γδ T cells that modulate airway hyperresponsiveness

Laura Cook, Nobuaki Miyahara, Niyun Jin, J. M. Wands, Christian Taube, Christina L. Roark, Terry A. Potter, Erwin W. Gelfand, Rebecca L. O'Brien, Willi K. Born

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Airway hyperresponsiveness (AHR), a hallmark of asthma and several other diseases, can be modulated by γδ T cells. In mice sensitized and challenged with OVA, AHR depends on allergen-specific αβ T cells; but Vγ1+ γδ T cells spontaneously enhance AHR, whereas Vγ4+ γδ T cells, after being induced by airway challenge, suppress AHR. The activity of these γδ T cell modulators is allergen nonspecific, and how they develop is unclear. We now show that CD8 is essential for the development of both the AHR suppressor and enhancer γδ T cells, although neither type needs to express CD8 itself. Both cell types encounter CD8-expressing non-T cells in the spleen, and their functional development in an otherwise CD8-negative environment can be restored with transferred spleen cell preparations containing CD8+ dendritic cells (DCs), but not CD8+ T cells or CD8- DCs. Our findings suggest that CD8+ DCs in the lymphoid tissues enable an early step in the development of γδ T cells through direct cell contact. DC-expressed CD8 might take part in this interaction.

Original languageEnglish
Pages (from-to)309-319
Number of pages11
JournalJournal of Immunology
Volume181
Issue number1
DOIs
Publication statusPublished - 2008
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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