Evidence for association between a Toll-like receptor 4 gene polymorphism and moderate/severe periodontitis in the Japanese population

T. Fukusaki, Naoya Oohara, Y. Hara, A. Yoshimura, K. Yoshiura

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Background and Objective: Chronic periodontitis is an inflammatory disease caused by bacteria in subgingival pockets. Because Toll-like receptor 2 and Toll-like receptor 4 have been shown to play an important role in the recognition of periodontal pathogens, we investigated the relevance of genetic variations in TLR2 and TLR4 to susceptibility to periodontitis. A total of 97 patients with chronic periodontitis and 100 control subjects were examined for mutations in TLR2 and TLR4. Case-control analysis was performed using individual single nucleotide polymorphisms detected during the mutation search. The missense mutations reported previously in TLR2 (677 Arg>Trp and 753 Arg>Gln) and in TLR4 (299 Asp>Gly and 399 Thr>Ile) were not detected in 97 of the Japanese patients with chronic periodontitis or in 100 of the Japanese control subjects. Nine single nucleotide polymorphisms were identified in exons of TLR2 and TLR4. The case-control analysis revealed that the frequency of the C/C genotype at base-pair position +3725 in TLR4 was significantly higher in both the moderate and the severe periodontitis patient group than in the control group. A genetic variation of TLR4 might be associated with moderate and severe periodontitis in the Japanese population.

Original languageEnglish
Pages (from-to)541-545
Number of pages5
JournalJournal of Periodontal Research
Volume42
Issue number6
DOIs
Publication statusPublished - Dec 2007
Externally publishedYes

Fingerprint

Chronic Periodontitis
Toll-Like Receptor 4
Periodontitis
Single Nucleotide Polymorphism
Population
Genes
Toll-Like Receptor 2
Mutation
Missense Mutation
Viperidae
Base Pairing
Exons
Genotype
Bacteria
Control Groups

Keywords

  • Chronic periodontitis
  • Polymorphism
  • Toll-like receptor 2
  • Toll-like receptor 4

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Evidence for association between a Toll-like receptor 4 gene polymorphism and moderate/severe periodontitis in the Japanese population. / Fukusaki, T.; Oohara, Naoya; Hara, Y.; Yoshimura, A.; Yoshiura, K.

In: Journal of Periodontal Research, Vol. 42, No. 6, 12.2007, p. 541-545.

Research output: Contribution to journalArticle

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