The purpose of this study was to investigate the predictive factors of weight loss in head and neck cancer patients treated by intensity-modulated radiation therapy（IMRT）. We retrospectively reviewed 43 patients with head and neck cancers treated with radical RT at doses ≥ 60Gy from January 2016 to December 2018. All patients received chemo-IMRT. The median weight loss was 8.5％. The incidence of weight loss ≥ 5％ was 88％ （38 patients）and ≥ 10％ was 35％（15 patients）. The factors significantly associated with ≥ 10％weight loss in the univariate analysis were younger age（p＝0.009）, size of planning target volume for gross tumor volume （＜0.001）, size of total planning target volume including prophylactic nodal areas（p＝0.021）, presence of lymph node metastasis（p＝0.04）, higher maximum radiation dose in the oral cavity（p＝0.02）, and dental status（max-illary and/or mandibular edentulous, p＝0.008）. Sex, body mass index, tumor site, T stage, diabetes mellitus, percutaneous endoscopic gastrostomy, and mean dose of radiation in the oral cavity were not significantly associated with weight loss. In multivariate analysis of ≥ 10％ weight loss, younger age（p＝0.03）and dental status （dentulous patient, p＝0.013）were significantly associated with weight loss. From these results, younger age and dental status（dentulous patient）might be predictors of ≥ 10％ weight loss during IMRT for head and neck cancer.
- Head and neck cancer
- Intensity-modulated radiation therapy
- Predictive factors
- Weight loss
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