TY - JOUR
T1 - Evaluation of weight loss during intensity-modulated radiation therapy for head and neck cancer patients
AU - Matsuzaki, Hidenobu
AU - Katsui, Kuniaki
AU - Matsuzaki, Kumiko
AU - Nagamoto, Yukiko
AU - Takahara, Yoko
AU - Kubo, Kazuko
AU - Kajikiyo, Tomomi
AU - Mizukawa, Nobuyoshi
AU - Kariya, Shin
AU - Yoshiyama, Masahiro
AU - Asaumi, Jun Ichi
AU - Kimata, Yoshihiro
N1 - Publisher Copyright:
© 2020, Japan Society for Head and Neck Cancer. All rights reserved.
PY - 2020
Y1 - 2020
N2 - The purpose of this study was to investigate the predictive factors of weight loss in head and neck cancer patients treated by intensity-modulated radiation therapy(IMRT). We retrospectively reviewed 43 patients with head and neck cancers treated with radical RT at doses ≥ 60Gy from January 2016 to December 2018. All patients received chemo-IMRT. The median weight loss was 8.5%. The incidence of weight loss ≥ 5% was 88% (38 patients)and ≥ 10% was 35%(15 patients). The factors significantly associated with ≥ 10%weight loss in the univariate analysis were younger age(p=0.009), size of planning target volume for gross tumor volume (<0.001), size of total planning target volume including prophylactic nodal areas(p=0.021), presence of lymph node metastasis(p=0.04), higher maximum radiation dose in the oral cavity(p=0.02), and dental status(max-illary and/or mandibular edentulous, p=0.008). Sex, body mass index, tumor site, T stage, diabetes mellitus, percutaneous endoscopic gastrostomy, and mean dose of radiation in the oral cavity were not significantly associated with weight loss. In multivariate analysis of ≥ 10% weight loss, younger age(p=0.03)and dental status (dentulous patient, p=0.013)were significantly associated with weight loss. From these results, younger age and dental status(dentulous patient)might be predictors of ≥ 10% weight loss during IMRT for head and neck cancer.
AB - The purpose of this study was to investigate the predictive factors of weight loss in head and neck cancer patients treated by intensity-modulated radiation therapy(IMRT). We retrospectively reviewed 43 patients with head and neck cancers treated with radical RT at doses ≥ 60Gy from January 2016 to December 2018. All patients received chemo-IMRT. The median weight loss was 8.5%. The incidence of weight loss ≥ 5% was 88% (38 patients)and ≥ 10% was 35%(15 patients). The factors significantly associated with ≥ 10%weight loss in the univariate analysis were younger age(p=0.009), size of planning target volume for gross tumor volume (<0.001), size of total planning target volume including prophylactic nodal areas(p=0.021), presence of lymph node metastasis(p=0.04), higher maximum radiation dose in the oral cavity(p=0.02), and dental status(max-illary and/or mandibular edentulous, p=0.008). Sex, body mass index, tumor site, T stage, diabetes mellitus, percutaneous endoscopic gastrostomy, and mean dose of radiation in the oral cavity were not significantly associated with weight loss. In multivariate analysis of ≥ 10% weight loss, younger age(p=0.03)and dental status (dentulous patient, p=0.013)were significantly associated with weight loss. From these results, younger age and dental status(dentulous patient)might be predictors of ≥ 10% weight loss during IMRT for head and neck cancer.
KW - Head and neck cancer
KW - Intensity-modulated radiation therapy
KW - Predictive factors
KW - Weight loss
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U2 - 10.5981/jjhnc.46.264
DO - 10.5981/jjhnc.46.264
M3 - Article
AN - SCOPUS:85096056166
VL - 46
SP - 264
EP - 269
JO - Japanese Journal of Head and Neck Cancer
JF - Japanese Journal of Head and Neck Cancer
SN - 1349-5747
IS - 3
ER -