Evaluation of variability of proteinuria indices

Masahiro Yoshimoto, Hirokazu Tsukahara, Masakazu Saito, Shuhei Hayashi, Shinichi Haruki, Shinichi Fujisawa, Masakatsu Sudo

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

We compared several indices of proteinuria, namely protein concentration, hourly protein excretion rate (Up/h) and protein/creatinine ratio (Up/Ucr) in single voided urine samples as well as 24 h-urinary protein excretion (24 h-Up), in 44 children, aged 4-16 years, with varying degrees of urinary protein excretion. We found an excellent correlation between Up/h and Up/Ucr in early morning samples. These two indices in early morning samples had excellent correlation with 24 h-Up, comparable to those in any other urine sample of the day. Among daytime samples, Up/h varied widely, in contrast to Up/Ucr, which had significantly less variability. We analysed six early morning and six bedtime samples from 39 of these subjects, and found smaller coefficients of variation for individual patient's indices in morning samples. Up/h was more variable than Up/Ucr, especially in bedtime samples. Urinary protein concentration had a poorer correlation with 24 h-Up and was more variable than any other index. We conclude that the Up/Ucr in early morning samples, which has the advantages both of simplicity and low day-to-day variability in a given patient, is a superior index of proteinuria.

Original languageEnglish
Pages (from-to)136-139
Number of pages4
JournalPediatric Nephrology
Volume4
Issue number2
DOIs
Publication statusPublished - Mar 1990
Externally publishedYes

Fingerprint

Proteinuria
Proteins
Urine
Creatinine

Keywords

  • Creatinine
  • Exercise
  • Glomerulonephritis
  • Proteinuria
  • Urinary protein/creatinine ratio

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

Cite this

Yoshimoto, M., Tsukahara, H., Saito, M., Hayashi, S., Haruki, S., Fujisawa, S., & Sudo, M. (1990). Evaluation of variability of proteinuria indices. Pediatric Nephrology, 4(2), 136-139. https://doi.org/10.1007/BF00858824

Evaluation of variability of proteinuria indices. / Yoshimoto, Masahiro; Tsukahara, Hirokazu; Saito, Masakazu; Hayashi, Shuhei; Haruki, Shinichi; Fujisawa, Shinichi; Sudo, Masakatsu.

In: Pediatric Nephrology, Vol. 4, No. 2, 03.1990, p. 136-139.

Research output: Contribution to journalArticle

Yoshimoto, M, Tsukahara, H, Saito, M, Hayashi, S, Haruki, S, Fujisawa, S & Sudo, M 1990, 'Evaluation of variability of proteinuria indices', Pediatric Nephrology, vol. 4, no. 2, pp. 136-139. https://doi.org/10.1007/BF00858824
Yoshimoto M, Tsukahara H, Saito M, Hayashi S, Haruki S, Fujisawa S et al. Evaluation of variability of proteinuria indices. Pediatric Nephrology. 1990 Mar;4(2):136-139. https://doi.org/10.1007/BF00858824
Yoshimoto, Masahiro ; Tsukahara, Hirokazu ; Saito, Masakazu ; Hayashi, Shuhei ; Haruki, Shinichi ; Fujisawa, Shinichi ; Sudo, Masakatsu. / Evaluation of variability of proteinuria indices. In: Pediatric Nephrology. 1990 ; Vol. 4, No. 2. pp. 136-139.
@article{9a638fa1548347bfb784602262dd8dd1,
title = "Evaluation of variability of proteinuria indices",
abstract = "We compared several indices of proteinuria, namely protein concentration, hourly protein excretion rate (Up/h) and protein/creatinine ratio (Up/Ucr) in single voided urine samples as well as 24 h-urinary protein excretion (24 h-Up), in 44 children, aged 4-16 years, with varying degrees of urinary protein excretion. We found an excellent correlation between Up/h and Up/Ucr in early morning samples. These two indices in early morning samples had excellent correlation with 24 h-Up, comparable to those in any other urine sample of the day. Among daytime samples, Up/h varied widely, in contrast to Up/Ucr, which had significantly less variability. We analysed six early morning and six bedtime samples from 39 of these subjects, and found smaller coefficients of variation for individual patient's indices in morning samples. Up/h was more variable than Up/Ucr, especially in bedtime samples. Urinary protein concentration had a poorer correlation with 24 h-Up and was more variable than any other index. We conclude that the Up/Ucr in early morning samples, which has the advantages both of simplicity and low day-to-day variability in a given patient, is a superior index of proteinuria.",
keywords = "Creatinine, Exercise, Glomerulonephritis, Proteinuria, Urinary protein/creatinine ratio",
author = "Masahiro Yoshimoto and Hirokazu Tsukahara and Masakazu Saito and Shuhei Hayashi and Shinichi Haruki and Shinichi Fujisawa and Masakatsu Sudo",
year = "1990",
month = "3",
doi = "10.1007/BF00858824",
language = "English",
volume = "4",
pages = "136--139",
journal = "Pediatric Nephrology",
issn = "0931-041X",
publisher = "Springer Verlag",
number = "2",

}

TY - JOUR

T1 - Evaluation of variability of proteinuria indices

AU - Yoshimoto, Masahiro

AU - Tsukahara, Hirokazu

AU - Saito, Masakazu

AU - Hayashi, Shuhei

AU - Haruki, Shinichi

AU - Fujisawa, Shinichi

AU - Sudo, Masakatsu

PY - 1990/3

Y1 - 1990/3

N2 - We compared several indices of proteinuria, namely protein concentration, hourly protein excretion rate (Up/h) and protein/creatinine ratio (Up/Ucr) in single voided urine samples as well as 24 h-urinary protein excretion (24 h-Up), in 44 children, aged 4-16 years, with varying degrees of urinary protein excretion. We found an excellent correlation between Up/h and Up/Ucr in early morning samples. These two indices in early morning samples had excellent correlation with 24 h-Up, comparable to those in any other urine sample of the day. Among daytime samples, Up/h varied widely, in contrast to Up/Ucr, which had significantly less variability. We analysed six early morning and six bedtime samples from 39 of these subjects, and found smaller coefficients of variation for individual patient's indices in morning samples. Up/h was more variable than Up/Ucr, especially in bedtime samples. Urinary protein concentration had a poorer correlation with 24 h-Up and was more variable than any other index. We conclude that the Up/Ucr in early morning samples, which has the advantages both of simplicity and low day-to-day variability in a given patient, is a superior index of proteinuria.

AB - We compared several indices of proteinuria, namely protein concentration, hourly protein excretion rate (Up/h) and protein/creatinine ratio (Up/Ucr) in single voided urine samples as well as 24 h-urinary protein excretion (24 h-Up), in 44 children, aged 4-16 years, with varying degrees of urinary protein excretion. We found an excellent correlation between Up/h and Up/Ucr in early morning samples. These two indices in early morning samples had excellent correlation with 24 h-Up, comparable to those in any other urine sample of the day. Among daytime samples, Up/h varied widely, in contrast to Up/Ucr, which had significantly less variability. We analysed six early morning and six bedtime samples from 39 of these subjects, and found smaller coefficients of variation for individual patient's indices in morning samples. Up/h was more variable than Up/Ucr, especially in bedtime samples. Urinary protein concentration had a poorer correlation with 24 h-Up and was more variable than any other index. We conclude that the Up/Ucr in early morning samples, which has the advantages both of simplicity and low day-to-day variability in a given patient, is a superior index of proteinuria.

KW - Creatinine

KW - Exercise

KW - Glomerulonephritis

KW - Proteinuria

KW - Urinary protein/creatinine ratio

UR - http://www.scopus.com/inward/record.url?scp=0025360019&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025360019&partnerID=8YFLogxK

U2 - 10.1007/BF00858824

DO - 10.1007/BF00858824

M3 - Article

C2 - 2397179

AN - SCOPUS:0025360019

VL - 4

SP - 136

EP - 139

JO - Pediatric Nephrology

JF - Pediatric Nephrology

SN - 0931-041X

IS - 2

ER -