Abstract
To examine the pharmaceutical application of Fourier transform (FT)-Raman spectroscopy, the state of active pharmaceutical ingredients (APIs) in a preparation of several forms was evaluated by investigating the Raman difference spectra between the preparation and excipient. The difference spectra indicated that APIs in alacepril tablets, caffeine sustained-release granules, and quinidine sulfate granules remained unchanged after the manufacturing process. However, the state of sparfloxacin in nanoparticles changed, although it remained unchanged in tablets or powders. These results show that the FT-Raman difference spectrum is expected to be utilized in the field of quality control of crystalline pharmaceutical preparations.
| Original language | English |
|---|---|
| Pages (from-to) | 1363-1367 |
| Number of pages | 5 |
| Journal | Yakugaku Zasshi |
| Volume | 126 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 2006 |
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Keywords
- Active pharmaceutical ingredient
- Difference spectrum
- Fourier transform-Raman spectroscopy
- Qualitative analysis
ASJC Scopus subject areas
- Molecular Medicine
Cite this
Evaluation of the state of active ingredients in pharmaceutical preparations using Fourier transform-Raman difference spectra. / Mifune, Masaki; Iwasaki, Toshinobu; Kozaki, Yukari; Tsukamoto, Ikuko; Saito, Madoka; Kitamura, Youji; Yamaguchi, Toshikazu; Saito, Yutaka.
In: Yakugaku Zasshi, Vol. 126, No. 12, 12.2006, p. 1363-1367.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evaluation of the state of active ingredients in pharmaceutical preparations using Fourier transform-Raman difference spectra
AU - Mifune, Masaki
AU - Iwasaki, Toshinobu
AU - Kozaki, Yukari
AU - Tsukamoto, Ikuko
AU - Saito, Madoka
AU - Kitamura, Youji
AU - Yamaguchi, Toshikazu
AU - Saito, Yutaka
PY - 2006/12
Y1 - 2006/12
N2 - To examine the pharmaceutical application of Fourier transform (FT)-Raman spectroscopy, the state of active pharmaceutical ingredients (APIs) in a preparation of several forms was evaluated by investigating the Raman difference spectra between the preparation and excipient. The difference spectra indicated that APIs in alacepril tablets, caffeine sustained-release granules, and quinidine sulfate granules remained unchanged after the manufacturing process. However, the state of sparfloxacin in nanoparticles changed, although it remained unchanged in tablets or powders. These results show that the FT-Raman difference spectrum is expected to be utilized in the field of quality control of crystalline pharmaceutical preparations.
AB - To examine the pharmaceutical application of Fourier transform (FT)-Raman spectroscopy, the state of active pharmaceutical ingredients (APIs) in a preparation of several forms was evaluated by investigating the Raman difference spectra between the preparation and excipient. The difference spectra indicated that APIs in alacepril tablets, caffeine sustained-release granules, and quinidine sulfate granules remained unchanged after the manufacturing process. However, the state of sparfloxacin in nanoparticles changed, although it remained unchanged in tablets or powders. These results show that the FT-Raman difference spectrum is expected to be utilized in the field of quality control of crystalline pharmaceutical preparations.
KW - Active pharmaceutical ingredient
KW - Difference spectrum
KW - Fourier transform-Raman spectroscopy
KW - Qualitative analysis
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UR - http://www.scopus.com/inward/citedby.url?scp=33846179021&partnerID=8YFLogxK
U2 - 10.1248/yakushi.126.1363
DO - 10.1248/yakushi.126.1363
M3 - Article
VL - 126
SP - 1363
EP - 1367
JO - Yakugaku Zasshi
JF - Yakugaku Zasshi
SN - 0031-6903
IS - 12
ER -