Evaluation of the state of active ingredients in pharmaceutical preparations using Fourier transform-Raman difference spectra

Masaki Mifune, Toshinobu Iwasaki, Yukari Kozaki, Ikuko Tsukamoto, Madoka Saito, Youji Kitamura, Toshikazu Yamaguchi, Yutaka Saito

Research output: Contribution to journalArticle


To examine the pharmaceutical application of Fourier transform (FT)-Raman spectroscopy, the state of active pharmaceutical ingredients (APIs) in a preparation of several forms was evaluated by investigating the Raman difference spectra between the preparation and excipient. The difference spectra indicated that APIs in alacepril tablets, caffeine sustained-release granules, and quinidine sulfate granules remained unchanged after the manufacturing process. However, the state of sparfloxacin in nanoparticles changed, although it remained unchanged in tablets or powders. These results show that the FT-Raman difference spectrum is expected to be utilized in the field of quality control of crystalline pharmaceutical preparations.

Original languageEnglish
Pages (from-to)1363-1367
Number of pages5
JournalYakugaku Zasshi
Issue number12
Publication statusPublished - Dec 1 2006



  • Active pharmaceutical ingredient
  • Difference spectrum
  • Fourier transform-Raman spectroscopy
  • Qualitative analysis

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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