TY - JOUR
T1 - Evaluation of the novel myocardial perfusion positron-emission tomography tracer 18F-BMS-747158-02
T2 - Comparison to 13N-ammonia and validation with microspheres in a pig model
AU - Nekolla, S. G.
AU - Reder, S.
AU - Saraste, A.
AU - Higuchi, T.
AU - Dzewas, G.
AU - Preissel, A.
AU - Huisman, M.
AU - Poethko, T.
AU - Schuster, T.
AU - Yu, M.
AU - Robinson, S.
AU - Casebier, D.
AU - Henke, J.
AU - Wester, H. J.
AU - Schwaiger, M.
PY - 2009/5/5
Y1 - 2009/5/5
N2 - BACKGROUND-: Positron-emission tomography (PET) tracers for myocardial perfusion are commonly labeled with short-lived isotopes that limit their widespread clinical use. F-BMS-747158-02 (F-BMS) is a novel pyridaben derivative that was evaluated for assessment of myocardial perfusion by comparison with N-ammonia (NH3) and with radioactive microspheres in a pig model. METHODS AND RESULTS-: Fourteen pigs injected with 500 MBq of NH3 or 100 to 200 MBq of F-BMS underwent dynamic PET at rest and during pharmacological stress. In 8 of these pigs, F-BMS was injected during stress combined with transient, 2.5-minute constriction of the left anterior descending coronary artery. Radioactive microspheres were coinjected with F-BMS. Ratios of myocardial tracer uptake to surrounding tissues were determined, and myocardial blood flow was quantified by compartmental modeling. Both tracers showed high and homogeneous myocardial uptake. Compared with NH3, F-BMS showed higher activity ratios between myocardium and blood (rest 2.5 versus 4.1; stress 2.1 versus 5.8), liver (rest 1.2 versus 1.8; stress 0.7 versus 2.0), and lungs (rest 2.5 versus 4.2; stress 2.9 versus 6.4). Regional myocardial blood flow assessed with F-BMS PET showed good correlation (r=0.88, slope=0.84) and agreement (mean difference -0.10 [25th percentile -0.3, 75th percentile 0.1 mL • min • g]) with that measured with radioactive microspheres over a flow range from 0.1 to 3.0 mL • min • g. The extent of defects induced by left anterior descending coronary artery constriction measured by F-BMS and microspheres also correlated closely (r=0.63, slope=1.1). CONCLUSIONS-: F-BMS-747158-02 is a very attractive new PET perfusion tracer that allows quantitative assessment of regional myocardial perfusion over a wide flow range. The long half-life of F renders this tracer useful for clinical PET/CT applications in the workup of patients with suspected or proven coronary artery disease.
AB - BACKGROUND-: Positron-emission tomography (PET) tracers for myocardial perfusion are commonly labeled with short-lived isotopes that limit their widespread clinical use. F-BMS-747158-02 (F-BMS) is a novel pyridaben derivative that was evaluated for assessment of myocardial perfusion by comparison with N-ammonia (NH3) and with radioactive microspheres in a pig model. METHODS AND RESULTS-: Fourteen pigs injected with 500 MBq of NH3 or 100 to 200 MBq of F-BMS underwent dynamic PET at rest and during pharmacological stress. In 8 of these pigs, F-BMS was injected during stress combined with transient, 2.5-minute constriction of the left anterior descending coronary artery. Radioactive microspheres were coinjected with F-BMS. Ratios of myocardial tracer uptake to surrounding tissues were determined, and myocardial blood flow was quantified by compartmental modeling. Both tracers showed high and homogeneous myocardial uptake. Compared with NH3, F-BMS showed higher activity ratios between myocardium and blood (rest 2.5 versus 4.1; stress 2.1 versus 5.8), liver (rest 1.2 versus 1.8; stress 0.7 versus 2.0), and lungs (rest 2.5 versus 4.2; stress 2.9 versus 6.4). Regional myocardial blood flow assessed with F-BMS PET showed good correlation (r=0.88, slope=0.84) and agreement (mean difference -0.10 [25th percentile -0.3, 75th percentile 0.1 mL • min • g]) with that measured with radioactive microspheres over a flow range from 0.1 to 3.0 mL • min • g. The extent of defects induced by left anterior descending coronary artery constriction measured by F-BMS and microspheres also correlated closely (r=0.63, slope=1.1). CONCLUSIONS-: F-BMS-747158-02 is a very attractive new PET perfusion tracer that allows quantitative assessment of regional myocardial perfusion over a wide flow range. The long half-life of F renders this tracer useful for clinical PET/CT applications in the workup of patients with suspected or proven coronary artery disease.
KW - Ischemia
KW - Microspheres
KW - Perfusion
KW - Positron-emission tomography
KW - Regional blood flow
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U2 - 10.1161/CIRCULATIONAHA.108.797761
DO - 10.1161/CIRCULATIONAHA.108.797761
M3 - Article
C2 - 19380625
AN - SCOPUS:66349108176
SN - 0009-7322
VL - 119
SP - 2333
EP - 2342
JO - Circulation
JF - Circulation
IS - 17
ER -