Evaluation of the novel myocardial perfusion positron-emission tomography tracer 18F-BMS-747158-02: Comparison to 13N-ammonia and validation with microspheres in a pig model

S. G. Nekolla, S. Reder, A. Saraste, T. Higuchi, G. Dzewas, A. Preissel, M. Huisman, T. Poethko, T. Schuster, M. Yu, S. Robinson, D. Casebier, J. Henke, H. J. Wester, M. Schwaiger

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Abstract

BACKGROUND-: Positron-emission tomography (PET) tracers for myocardial perfusion are commonly labeled with short-lived isotopes that limit their widespread clinical use. F-BMS-747158-02 (F-BMS) is a novel pyridaben derivative that was evaluated for assessment of myocardial perfusion by comparison with N-ammonia (NH3) and with radioactive microspheres in a pig model. METHODS AND RESULTS-: Fourteen pigs injected with 500 MBq of NH3 or 100 to 200 MBq of F-BMS underwent dynamic PET at rest and during pharmacological stress. In 8 of these pigs, F-BMS was injected during stress combined with transient, 2.5-minute constriction of the left anterior descending coronary artery. Radioactive microspheres were coinjected with F-BMS. Ratios of myocardial tracer uptake to surrounding tissues were determined, and myocardial blood flow was quantified by compartmental modeling. Both tracers showed high and homogeneous myocardial uptake. Compared with NH3, F-BMS showed higher activity ratios between myocardium and blood (rest 2.5 versus 4.1; stress 2.1 versus 5.8), liver (rest 1.2 versus 1.8; stress 0.7 versus 2.0), and lungs (rest 2.5 versus 4.2; stress 2.9 versus 6.4). Regional myocardial blood flow assessed with F-BMS PET showed good correlation (r=0.88, slope=0.84) and agreement (mean difference -0.10 [25th percentile -0.3, 75th percentile 0.1 mL • min • g]) with that measured with radioactive microspheres over a flow range from 0.1 to 3.0 mL • min • g. The extent of defects induced by left anterior descending coronary artery constriction measured by F-BMS and microspheres also correlated closely (r=0.63, slope=1.1). CONCLUSIONS-: F-BMS-747158-02 is a very attractive new PET perfusion tracer that allows quantitative assessment of regional myocardial perfusion over a wide flow range. The long half-life of F renders this tracer useful for clinical PET/CT applications in the workup of patients with suspected or proven coronary artery disease.

Original languageEnglish
Pages (from-to)2333-2342
Number of pages10
JournalCirculation
Volume119
Issue number17
DOIs
Publication statusPublished - May 5 2009
Externally publishedYes

Keywords

  • Ischemia
  • Microspheres
  • Perfusion
  • Positron-emission tomography
  • Regional blood flow

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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    Nekolla, S. G., Reder, S., Saraste, A., Higuchi, T., Dzewas, G., Preissel, A., Huisman, M., Poethko, T., Schuster, T., Yu, M., Robinson, S., Casebier, D., Henke, J., Wester, H. J., & Schwaiger, M. (2009). Evaluation of the novel myocardial perfusion positron-emission tomography tracer 18F-BMS-747158-02: Comparison to 13N-ammonia and validation with microspheres in a pig model. Circulation, 119(17), 2333-2342. https://doi.org/10.1161/CIRCULATIONAHA.108.797761