Evaluation of the mutagenicity and the tumor-promoting activity of parasite extracts: Schistosoma japonicum and Clonorchis sinensis

Akira Ishii, Hiroyuki Matsuoka, Toshiki Aji, Hikoya Hayatsu, Yusuke Wataya, Sakae Arimoto, Harukuni Tokuda

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

In relation to the observed association of carcinogenesis with parasitic infections, the mutagenicity of extracts of Schistosoma japonicum and Clonorchis sinensis was examined. In the bacterial mutagenicity tests using the Ames Salmonella typhimurium strains TA98, TA100, TA97 and TA102, and Escherichia coli WP2 and WP2 uvrA pKM101 Schistosoma soluble egg antigen and a homogenate of adult Schistosoma worms showed no positive responses either in the presence or in the absence of S9 mix. Likewise, adult worm extracts of Clonorchis showed no mutagenicity. The Schistosoma soluble egg antigen showed a weak but significant activity for the induction of Epstein-Barr virus expression in viral genome-carrying human lymphoblastoid cells in culture. This phenomenon suggests that the soluble egg antigen possesses tumor-promoting activity.

Original languageEnglish
Pages (from-to)229-233
Number of pages5
JournalMutation Research/Genetic Toxicology
Volume224
Issue number2
DOIs
Publication statusPublished - 1989

Fingerprint

Clonorchis sinensis
Schistosoma
Schistosoma japonicum
Ovum
Tumors
Parasites
Antigens
Mutagenicity Tests
Neoplasms
Parasitic Diseases
Salmonella
Viral Genome
Neoplasm Antigens
Salmonella typhimurium
Human Herpesvirus 4
Viruses
Cell culture
Escherichia coli
Carcinogenesis
Cell Culture Techniques

Keywords

  • Clonorchis
  • Mutagenicity
  • Parasite
  • Schistosoma
  • Tumor-promoting activity

ASJC Scopus subject areas

  • Genetics
  • Toxicology
  • Medicine(all)

Cite this

Evaluation of the mutagenicity and the tumor-promoting activity of parasite extracts : Schistosoma japonicum and Clonorchis sinensis. / Ishii, Akira; Matsuoka, Hiroyuki; Aji, Toshiki; Hayatsu, Hikoya; Wataya, Yusuke; Arimoto, Sakae; Tokuda, Harukuni.

In: Mutation Research/Genetic Toxicology, Vol. 224, No. 2, 1989, p. 229-233.

Research output: Contribution to journalArticle

Ishii, Akira ; Matsuoka, Hiroyuki ; Aji, Toshiki ; Hayatsu, Hikoya ; Wataya, Yusuke ; Arimoto, Sakae ; Tokuda, Harukuni. / Evaluation of the mutagenicity and the tumor-promoting activity of parasite extracts : Schistosoma japonicum and Clonorchis sinensis. In: Mutation Research/Genetic Toxicology. 1989 ; Vol. 224, No. 2. pp. 229-233.
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