Evaluation of the effects of anti-pruritic drugs on scratch responses using histamine H1 receptor-deficient mice

Yukio Sugimoto, Yosuke Nakamura, Maria Alejandra Hossen, Takeshi Watanabe, Chiaki Kamei

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The effects of anti-pruritic drugs on scratching behavior associated with passive cutaneous anaphylaxis in histamine H1 receptor-deficient and wild-type mice were studied. Passive sensitization with mouse monoclonal anti-dinitrophenyl-immunoglobulin E (IgE) resulted in an increase in the incidence of scratching behavior induced by intravenous injection of dinitrophenyl-ovalbumin in both wild-type and histamine H1 receptor-deficient mice. The histamine H1 receptor antagonist diphenhydramine inhibited scratching behavior induced by antigen in passively sensitized wild-type mice, whereas no effect was observed in histamine H1 receptor-deficient mice. On the other hand, oxatomide inhibited scratching behavior in both mice, although the effect in wild-type mice was more potent than that in histamine H1 receptor-deficient mice. Tranilast inhibited scratching behavior with the same potency in both mice. We concluded that the scratching behavior associated with passive cutaneous anaphylaxis involves not only histamine H1 receptors but also other chemical mediators. Furthermore, the results of the present study indicated that oxatomide has an antagonistic effect on histamine H1 receptors as well as anti-pruritic effect in vivo.

Original languageEnglish
Pages (from-to)113-116
Number of pages4
JournalEuropean Journal of Pharmacology
Volume470
Issue number1-2
DOIs
Publication statusPublished - May 30 2003

Fingerprint

Histamine H1 Receptors
oxatomide
Pharmaceutical Preparations
Passive Cutaneous Anaphylaxis
Histamine H1 Antagonists
Diphenhydramine
Ovalbumin
Intravenous Injections
Immunoglobulin E
Antigens

Keywords

  • Anti-allergic drug
  • Histamine H receptor
  • Histamine H receptor antagonist
  • Scratching behavior

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Evaluation of the effects of anti-pruritic drugs on scratch responses using histamine H1 receptor-deficient mice. / Sugimoto, Yukio; Nakamura, Yosuke; Hossen, Maria Alejandra; Watanabe, Takeshi; Kamei, Chiaki.

In: European Journal of Pharmacology, Vol. 470, No. 1-2, 30.05.2003, p. 113-116.

Research output: Contribution to journalArticle

Sugimoto, Yukio ; Nakamura, Yosuke ; Hossen, Maria Alejandra ; Watanabe, Takeshi ; Kamei, Chiaki. / Evaluation of the effects of anti-pruritic drugs on scratch responses using histamine H1 receptor-deficient mice. In: European Journal of Pharmacology. 2003 ; Vol. 470, No. 1-2. pp. 113-116.
@article{159c097f0e364ac6af2a322c03ded100,
title = "Evaluation of the effects of anti-pruritic drugs on scratch responses using histamine H1 receptor-deficient mice",
abstract = "The effects of anti-pruritic drugs on scratching behavior associated with passive cutaneous anaphylaxis in histamine H1 receptor-deficient and wild-type mice were studied. Passive sensitization with mouse monoclonal anti-dinitrophenyl-immunoglobulin E (IgE) resulted in an increase in the incidence of scratching behavior induced by intravenous injection of dinitrophenyl-ovalbumin in both wild-type and histamine H1 receptor-deficient mice. The histamine H1 receptor antagonist diphenhydramine inhibited scratching behavior induced by antigen in passively sensitized wild-type mice, whereas no effect was observed in histamine H1 receptor-deficient mice. On the other hand, oxatomide inhibited scratching behavior in both mice, although the effect in wild-type mice was more potent than that in histamine H1 receptor-deficient mice. Tranilast inhibited scratching behavior with the same potency in both mice. We concluded that the scratching behavior associated with passive cutaneous anaphylaxis involves not only histamine H1 receptors but also other chemical mediators. Furthermore, the results of the present study indicated that oxatomide has an antagonistic effect on histamine H1 receptors as well as anti-pruritic effect in vivo.",
keywords = "Anti-allergic drug, Histamine H receptor, Histamine H receptor antagonist, Scratching behavior",
author = "Yukio Sugimoto and Yosuke Nakamura and Hossen, {Maria Alejandra} and Takeshi Watanabe and Chiaki Kamei",
year = "2003",
month = "5",
day = "30",
doi = "10.1016/S0014-2999(03)01786-2",
language = "English",
volume = "470",
pages = "113--116",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Evaluation of the effects of anti-pruritic drugs on scratch responses using histamine H1 receptor-deficient mice

AU - Sugimoto, Yukio

AU - Nakamura, Yosuke

AU - Hossen, Maria Alejandra

AU - Watanabe, Takeshi

AU - Kamei, Chiaki

PY - 2003/5/30

Y1 - 2003/5/30

N2 - The effects of anti-pruritic drugs on scratching behavior associated with passive cutaneous anaphylaxis in histamine H1 receptor-deficient and wild-type mice were studied. Passive sensitization with mouse monoclonal anti-dinitrophenyl-immunoglobulin E (IgE) resulted in an increase in the incidence of scratching behavior induced by intravenous injection of dinitrophenyl-ovalbumin in both wild-type and histamine H1 receptor-deficient mice. The histamine H1 receptor antagonist diphenhydramine inhibited scratching behavior induced by antigen in passively sensitized wild-type mice, whereas no effect was observed in histamine H1 receptor-deficient mice. On the other hand, oxatomide inhibited scratching behavior in both mice, although the effect in wild-type mice was more potent than that in histamine H1 receptor-deficient mice. Tranilast inhibited scratching behavior with the same potency in both mice. We concluded that the scratching behavior associated with passive cutaneous anaphylaxis involves not only histamine H1 receptors but also other chemical mediators. Furthermore, the results of the present study indicated that oxatomide has an antagonistic effect on histamine H1 receptors as well as anti-pruritic effect in vivo.

AB - The effects of anti-pruritic drugs on scratching behavior associated with passive cutaneous anaphylaxis in histamine H1 receptor-deficient and wild-type mice were studied. Passive sensitization with mouse monoclonal anti-dinitrophenyl-immunoglobulin E (IgE) resulted in an increase in the incidence of scratching behavior induced by intravenous injection of dinitrophenyl-ovalbumin in both wild-type and histamine H1 receptor-deficient mice. The histamine H1 receptor antagonist diphenhydramine inhibited scratching behavior induced by antigen in passively sensitized wild-type mice, whereas no effect was observed in histamine H1 receptor-deficient mice. On the other hand, oxatomide inhibited scratching behavior in both mice, although the effect in wild-type mice was more potent than that in histamine H1 receptor-deficient mice. Tranilast inhibited scratching behavior with the same potency in both mice. We concluded that the scratching behavior associated with passive cutaneous anaphylaxis involves not only histamine H1 receptors but also other chemical mediators. Furthermore, the results of the present study indicated that oxatomide has an antagonistic effect on histamine H1 receptors as well as anti-pruritic effect in vivo.

KW - Anti-allergic drug

KW - Histamine H receptor

KW - Histamine H receptor antagonist

KW - Scratching behavior

UR - http://www.scopus.com/inward/record.url?scp=0038022798&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038022798&partnerID=8YFLogxK

U2 - 10.1016/S0014-2999(03)01786-2

DO - 10.1016/S0014-2999(03)01786-2

M3 - Article

VL - 470

SP - 113

EP - 116

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 1-2

ER -