Abstract
The scavenging rates of DOPA (dl- and l-3-(3,4-dihydroxyphenyl)alanine) and Tyr (tyrosine (dl- and l-3-(4-hydroxyphenyl)alanine)) against five reactive oxygen species (ROS) and methyl radical were measured with the use of electron spin resonance (ESR) spin-trapping method and the scavenging rate constants of DOPA and Tyr were determined. The scavenging rate constants for multiple active species increased in the order of O2- < RO < 1O2 < H3C < HO for Tyr and RO O2- < 1O2 H3C < HO for DOPA, and the differences in the radical scavenging abilities for l-enantiomers and dl-mixtures of DOPA and Tyr were shown. Further, based on the redox potentials, we have suggested that the primary chemical process of antioxidant reactions with O2- and 1O2 can be characterized with the electron transfer of antioxidants (DOPA and Tyr).
Original language | English |
---|---|
Pages (from-to) | 1808-1810 |
Number of pages | 3 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 25 |
Issue number | 8 |
DOIs | |
Publication status | Published - Apr 15 2015 |
Keywords
- DOPA
- ESR spin trapping
- Radical scavenging rate constant
- Tyrosine
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry