Abstract
Pervasive developmental disorder (PDD) and attention deficit hyperactivity disorder (ADHD) are likely to be associated with increased oxidative stress, particularly that of lipid peroxidation. We evaluated the oxidative stress status of pediatric PDD and ADHD patients using their urine samples. Urinary acrolein-lysine levels in 11 PDD and 10 ADHD children (205 ± 97 and 234 ± 75 nmol/mg Cr, respectively) appeared higher than those of the control subjects (155 ± 59 nmol/mg Cr). Measurement of urinary specific biomarkers is comfortable, non-invasive, and easy to perform in children. Our findings might provide a scientific guide for use in further clinical and biochemical studies of these disorders.
| Original language | English |
|---|---|
| Pages (from-to) | 45-46 |
| Number of pages | 2 |
| Journal | Redox Report |
| Volume | 16 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2011 |
| Externally published | Yes |
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Keywords
- Acrolein-lysine
- Attention deficit hyperactivity disorder
- Oxidative stress
- Pervasive developmental disorder
- Urinary biomarker
ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Clinical Biochemistry
- Biochemistry, medical
- Physiology
Cite this
Evaluation of oxidative stress status in children with pervasive developmental disorder and attention deficit hyperactivity disorder using urinary-specific biomarkers. / Kawatani, Masao; Tsukahara, Hirokazu; Mayumi, Mitsufumi.
In: Redox Report, Vol. 16, No. 1, 01.2011, p. 45-46.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evaluation of oxidative stress status in children with pervasive developmental disorder and attention deficit hyperactivity disorder using urinary-specific biomarkers
AU - Kawatani, Masao
AU - Tsukahara, Hirokazu
AU - Mayumi, Mitsufumi
PY - 2011/1
Y1 - 2011/1
N2 - Pervasive developmental disorder (PDD) and attention deficit hyperactivity disorder (ADHD) are likely to be associated with increased oxidative stress, particularly that of lipid peroxidation. We evaluated the oxidative stress status of pediatric PDD and ADHD patients using their urine samples. Urinary acrolein-lysine levels in 11 PDD and 10 ADHD children (205 ± 97 and 234 ± 75 nmol/mg Cr, respectively) appeared higher than those of the control subjects (155 ± 59 nmol/mg Cr). Measurement of urinary specific biomarkers is comfortable, non-invasive, and easy to perform in children. Our findings might provide a scientific guide for use in further clinical and biochemical studies of these disorders.
AB - Pervasive developmental disorder (PDD) and attention deficit hyperactivity disorder (ADHD) are likely to be associated with increased oxidative stress, particularly that of lipid peroxidation. We evaluated the oxidative stress status of pediatric PDD and ADHD patients using their urine samples. Urinary acrolein-lysine levels in 11 PDD and 10 ADHD children (205 ± 97 and 234 ± 75 nmol/mg Cr, respectively) appeared higher than those of the control subjects (155 ± 59 nmol/mg Cr). Measurement of urinary specific biomarkers is comfortable, non-invasive, and easy to perform in children. Our findings might provide a scientific guide for use in further clinical and biochemical studies of these disorders.
KW - Acrolein-lysine
KW - Attention deficit hyperactivity disorder
KW - Oxidative stress
KW - Pervasive developmental disorder
KW - Urinary biomarker
UR - http://www.scopus.com/inward/record.url?scp=79957836604&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79957836604&partnerID=8YFLogxK
U2 - 10.1179/174329211X12968219310873
DO - 10.1179/174329211X12968219310873
M3 - Article
C2 - 21605498
AN - SCOPUS:79957836604
VL - 16
SP - 45
EP - 46
JO - Redox Report
JF - Redox Report
SN - 1351-0002
IS - 1
ER -