Evaluation of new Cu(II) complexes as a novel class of inhibitors against plant carbonic anhydrase, glutathione reductase, and photosynthetic activity in photosystem II

Margarita V. Rodionova, Sergei K. Zharmukhamedov, Mehmet Sayım Karacan, Kubra Begum Venedik, Alexandr V. Shitov, Turgay Tunç, Serhat Mamaş, Vladimir D. Kreslavski, Nurcan Karacan, Vyacheslav V. Klimov, Suleyman Allakhverdiev

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Increasing inefficiency of production of important agricultural plants raises one of the biggest problems in the modern world. Herbicide application is still the best method of weed management. Traditional herbicides blocking only one of the plant metabolic pathways is ineffective due to the rapid growth of herbicide-resistant weeds. The synthesis of novel compounds effectively suppressing several metabolic processes, and therefore achieving the synergism effect would serve as the alternative approach to weed problem. For this reason, recently, we synthesized a series of nine novel Cu(II) complexes and four ligands, characterized them with different analyses techniques, and carried out their primary evaluation as inhibitors of photosynthetic electron transfer in spinach thylakoids (design, synthesis, and evaluation of a series of Cu(II) based metal–organic complexes as possible inhibitors of photosynthesis, J Photochem Photobiol B, submitted). Here, we evaluated in vitro inhibitory potency of these agents against: photochemistry and carbonic anhydrase activity of photosystem II (PSII); α-carbonic anhydrase from bovine erythrocytes; as well as glutathione reductase from chloroplast and baker’s yeast. Our results show that all Cu(II) complexes excellently inhibit glutathione reductase and PSII carbonic anhydrase activity. Some of them also decently inhibit PSII photosynthetic activity.

Original languageEnglish
Pages (from-to)139-153
Number of pages15
JournalPhotosynthesis Research
Volume133
Issue number1-3
DOIs
Publication statusPublished - Sep 1 2017
Externally publishedYes

Fingerprint

Carbonic Anhydrases
Photosystem II Protein Complex
Glutathione Reductase
carbonate dehydratase
Herbicides
glutathione-disulfide reductase
photosystem II
herbicide-resistant weeds
Photochemistry
bakers yeast
Thylakoids
synthesis
Spinacia oleracea
Photosynthesis
photochemistry
Photochemical reactions
synergism
Chloroplasts
Metabolic Networks and Pathways
spinach

Keywords

  • Carbonic anhydrase inhibitors
  • Glutathione reductase inhibitors
  • Photosynthetic inhibitors

ASJC Scopus subject areas

  • Biochemistry
  • Plant Science
  • Cell Biology

Cite this

Evaluation of new Cu(II) complexes as a novel class of inhibitors against plant carbonic anhydrase, glutathione reductase, and photosynthetic activity in photosystem II. / Rodionova, Margarita V.; Zharmukhamedov, Sergei K.; Karacan, Mehmet Sayım; Venedik, Kubra Begum; Shitov, Alexandr V.; Tunç, Turgay; Mamaş, Serhat; Kreslavski, Vladimir D.; Karacan, Nurcan; Klimov, Vyacheslav V.; Allakhverdiev, Suleyman.

In: Photosynthesis Research, Vol. 133, No. 1-3, 01.09.2017, p. 139-153.

Research output: Contribution to journalArticle

Rodionova, MV, Zharmukhamedov, SK, Karacan, MS, Venedik, KB, Shitov, AV, Tunç, T, Mamaş, S, Kreslavski, VD, Karacan, N, Klimov, VV & Allakhverdiev, S 2017, 'Evaluation of new Cu(II) complexes as a novel class of inhibitors against plant carbonic anhydrase, glutathione reductase, and photosynthetic activity in photosystem II', Photosynthesis Research, vol. 133, no. 1-3, pp. 139-153. https://doi.org/10.1007/s11120-017-0392-9
Rodionova, Margarita V. ; Zharmukhamedov, Sergei K. ; Karacan, Mehmet Sayım ; Venedik, Kubra Begum ; Shitov, Alexandr V. ; Tunç, Turgay ; Mamaş, Serhat ; Kreslavski, Vladimir D. ; Karacan, Nurcan ; Klimov, Vyacheslav V. ; Allakhverdiev, Suleyman. / Evaluation of new Cu(II) complexes as a novel class of inhibitors against plant carbonic anhydrase, glutathione reductase, and photosynthetic activity in photosystem II. In: Photosynthesis Research. 2017 ; Vol. 133, No. 1-3. pp. 139-153.
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