Evaluation of new Cu(II) complexes as a novel class of inhibitors against plant carbonic anhydrase, glutathione reductase, and photosynthetic activity in photosystem II

Margarita V. Rodionova, Sergei K. Zharmukhamedov, Mehmet Sayım Karacan, Kubra Begum Venedik, Alexandr V. Shitov, Turgay Tunç, Serhat Mamaş, Vladimir D. Kreslavski, Nurcan Karacan, Vyacheslav V. Klimov, Suleyman I. Allakhverdiev

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)

    Abstract

    Increasing inefficiency of production of important agricultural plants raises one of the biggest problems in the modern world. Herbicide application is still the best method of weed management. Traditional herbicides blocking only one of the plant metabolic pathways is ineffective due to the rapid growth of herbicide-resistant weeds. The synthesis of novel compounds effectively suppressing several metabolic processes, and therefore achieving the synergism effect would serve as the alternative approach to weed problem. For this reason, recently, we synthesized a series of nine novel Cu(II) complexes and four ligands, characterized them with different analyses techniques, and carried out their primary evaluation as inhibitors of photosynthetic electron transfer in spinach thylakoids (design, synthesis, and evaluation of a series of Cu(II) based metal–organic complexes as possible inhibitors of photosynthesis, J Photochem Photobiol B, submitted). Here, we evaluated in vitro inhibitory potency of these agents against: photochemistry and carbonic anhydrase activity of photosystem II (PSII); α-carbonic anhydrase from bovine erythrocytes; as well as glutathione reductase from chloroplast and baker’s yeast. Our results show that all Cu(II) complexes excellently inhibit glutathione reductase and PSII carbonic anhydrase activity. Some of them also decently inhibit PSII photosynthetic activity.

    Original languageEnglish
    Pages (from-to)139-153
    Number of pages15
    JournalPhotosynthesis research
    Volume133
    Issue number1-3
    DOIs
    Publication statusPublished - Sep 1 2017

    Keywords

    • Carbonic anhydrase inhibitors
    • Glutathione reductase inhibitors
    • Photosynthetic inhibitors

    ASJC Scopus subject areas

    • Biochemistry
    • Plant Science
    • Cell Biology

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