Evaluation of mucosal healing in ulcerative colitis by fecal calprotectin vs. fecal immunochemical test

Shiho Takashima, Jun Kato, Sakiko Hiraoka, Asuka Nakarai, Daisuke Takei, Toshihiro Inokuchi, Yuusaku Sugihara, Masahiro Takahara, Keita Harada, Hiroyuki Okada, Takehiro Tanaka, Kazuhide Yamamoto

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Abstract

We previously showed that a quantitative fecal immunochemical test (FIT) can predict mucosal healing (MH) in ulcerative colitis (UC). Fecal calprotectin (Fcal) has also been reported as an important biomarker of UC activity. The aim of this study was to compare the predictive ability of these two fecal markers for MH in UC.METHODS:FIT and Fcal were examined in stool samples from consecutive UC patients who underwent colonoscopy. Mucosal status was assessed via the Mayo endoscopic subscore (MES).RESULTS:In total, 105 colonoscopies in 92 UC patients were evaluated in conjunction with the FIT and Fcal results. Both FIT and Fcal results were significantly correlated with MES (Spearman's rank correlation coefficient: 0.61 and 0.58, respectively). The sensitivity and specificity of the FIT values (

Original languageEnglish
Pages (from-to)873-880
Number of pages8
JournalAmerican Journal of Gastroenterology
Volume110
Issue number6
DOIs
Publication statusPublished - Jun 10 2015

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Leukocyte L1 Antigen Complex
Ulcerative Colitis
Colonoscopy
Nonparametric Statistics
Biomarkers
Sensitivity and Specificity

ASJC Scopus subject areas

  • Gastroenterology
  • Medicine(all)

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Evaluation of mucosal healing in ulcerative colitis by fecal calprotectin vs. fecal immunochemical test. / Takashima, Shiho; Kato, Jun; Hiraoka, Sakiko; Nakarai, Asuka; Takei, Daisuke; Inokuchi, Toshihiro; Sugihara, Yuusaku; Takahara, Masahiro; Harada, Keita; Okada, Hiroyuki; Tanaka, Takehiro; Yamamoto, Kazuhide.

In: American Journal of Gastroenterology, Vol. 110, No. 6, 10.06.2015, p. 873-880.

Research output: Contribution to journalArticle

Takashima, Shiho ; Kato, Jun ; Hiraoka, Sakiko ; Nakarai, Asuka ; Takei, Daisuke ; Inokuchi, Toshihiro ; Sugihara, Yuusaku ; Takahara, Masahiro ; Harada, Keita ; Okada, Hiroyuki ; Tanaka, Takehiro ; Yamamoto, Kazuhide. / Evaluation of mucosal healing in ulcerative colitis by fecal calprotectin vs. fecal immunochemical test. In: American Journal of Gastroenterology. 2015 ; Vol. 110, No. 6. pp. 873-880.
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AU - Takei, Daisuke

AU - Inokuchi, Toshihiro

AU - Sugihara, Yuusaku

AU - Takahara, Masahiro

AU - Harada, Keita

AU - Okada, Hiroyuki

AU - Tanaka, Takehiro

AU - Yamamoto, Kazuhide

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