Evaluation of extracellular matrix protein CCN1 as a prognostic factor for glioblastoma

Joji Ishida, Kazuhiko Kurozumi, Tomotsugu Ichikawa, Yoshihiro Otani, Manabu Onishi, Kentaro Fujii, Yosuke Shimazu, Tetsuo Oka, Toshihiko Shimizu, Isao Date

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Recently, research efforts in identifying prognostic molecular biomarkers for malignant glioma have intensified. Cysteine-rich protein 61 (CCN1) is one of the CCN family of matricellular proteins that promotes cell growth and angiogenesis in cancers through its interaction with several integrins. In this study, we investigated the relationships among CCN1, O6-methylguanine-DNA methyltransferase expression, the tumor removal rate, and prognosis in 46 glioblastoma patients treated at the Okayama University Hospital. CCN1 expression was high in 31 (67 %) of these patients. The median progression-free survival (PFS) and overall survival (OS) times of patients with high CCN1 expression was significantly shorter than those of patients with low CCN1 expression (p 

Original languageEnglish
Pages (from-to)245-252
Number of pages8
JournalBrain Tumor Pathology
Volume32
Issue number4
DOIs
Publication statusPublished - Oct 1 2015

Fingerprint

Extracellular Matrix Proteins
Glioblastoma
CCN Intercellular Signaling Proteins
Cysteine-Rich Protein 61
Methyltransferases
Integrins
Glioma
Disease-Free Survival
Neoplasms
Biomarkers
Survival
DNA
Growth
Research

Keywords

  • CCN1
  • Glioma
  • MGMT
  • Prognostic marker

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Clinical Neurology

Cite this

Evaluation of extracellular matrix protein CCN1 as a prognostic factor for glioblastoma. / Ishida, Joji; Kurozumi, Kazuhiko; Ichikawa, Tomotsugu; Otani, Yoshihiro; Onishi, Manabu; Fujii, Kentaro; Shimazu, Yosuke; Oka, Tetsuo; Shimizu, Toshihiko; Date, Isao.

In: Brain Tumor Pathology, Vol. 32, No. 4, 01.10.2015, p. 245-252.

Research output: Contribution to journalArticle

Ishida, Joji ; Kurozumi, Kazuhiko ; Ichikawa, Tomotsugu ; Otani, Yoshihiro ; Onishi, Manabu ; Fujii, Kentaro ; Shimazu, Yosuke ; Oka, Tetsuo ; Shimizu, Toshihiko ; Date, Isao. / Evaluation of extracellular matrix protein CCN1 as a prognostic factor for glioblastoma. In: Brain Tumor Pathology. 2015 ; Vol. 32, No. 4. pp. 245-252.
@article{5a2fdab3d12e45cc9fa7b7bc313383b6,
title = "Evaluation of extracellular matrix protein CCN1 as a prognostic factor for glioblastoma",
abstract = "Recently, research efforts in identifying prognostic molecular biomarkers for malignant glioma have intensified. Cysteine-rich protein 61 (CCN1) is one of the CCN family of matricellular proteins that promotes cell growth and angiogenesis in cancers through its interaction with several integrins. In this study, we investigated the relationships among CCN1, O6-methylguanine-DNA methyltransferase expression, the tumor removal rate, and prognosis in 46 glioblastoma patients treated at the Okayama University Hospital. CCN1 expression was high in 31 (67 {\%}) of these patients. The median progression-free survival (PFS) and overall survival (OS) times of patients with high CCN1 expression was significantly shorter than those of patients with low CCN1 expression (p ",
keywords = "CCN1, Glioma, MGMT, Prognostic marker",
author = "Joji Ishida and Kazuhiko Kurozumi and Tomotsugu Ichikawa and Yoshihiro Otani and Manabu Onishi and Kentaro Fujii and Yosuke Shimazu and Tetsuo Oka and Toshihiko Shimizu and Isao Date",
year = "2015",
month = "10",
day = "1",
doi = "10.1007/s10014-015-0227-3",
language = "English",
volume = "32",
pages = "245--252",
journal = "Brain Tumor Pathology",
issn = "1433-7398",
publisher = "Springer Japan",
number = "4",

}

TY - JOUR

T1 - Evaluation of extracellular matrix protein CCN1 as a prognostic factor for glioblastoma

AU - Ishida, Joji

AU - Kurozumi, Kazuhiko

AU - Ichikawa, Tomotsugu

AU - Otani, Yoshihiro

AU - Onishi, Manabu

AU - Fujii, Kentaro

AU - Shimazu, Yosuke

AU - Oka, Tetsuo

AU - Shimizu, Toshihiko

AU - Date, Isao

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Recently, research efforts in identifying prognostic molecular biomarkers for malignant glioma have intensified. Cysteine-rich protein 61 (CCN1) is one of the CCN family of matricellular proteins that promotes cell growth and angiogenesis in cancers through its interaction with several integrins. In this study, we investigated the relationships among CCN1, O6-methylguanine-DNA methyltransferase expression, the tumor removal rate, and prognosis in 46 glioblastoma patients treated at the Okayama University Hospital. CCN1 expression was high in 31 (67 %) of these patients. The median progression-free survival (PFS) and overall survival (OS) times of patients with high CCN1 expression was significantly shorter than those of patients with low CCN1 expression (p 

AB - Recently, research efforts in identifying prognostic molecular biomarkers for malignant glioma have intensified. Cysteine-rich protein 61 (CCN1) is one of the CCN family of matricellular proteins that promotes cell growth and angiogenesis in cancers through its interaction with several integrins. In this study, we investigated the relationships among CCN1, O6-methylguanine-DNA methyltransferase expression, the tumor removal rate, and prognosis in 46 glioblastoma patients treated at the Okayama University Hospital. CCN1 expression was high in 31 (67 %) of these patients. The median progression-free survival (PFS) and overall survival (OS) times of patients with high CCN1 expression was significantly shorter than those of patients with low CCN1 expression (p 

KW - CCN1

KW - Glioma

KW - MGMT

KW - Prognostic marker

UR - http://www.scopus.com/inward/record.url?scp=84945491162&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84945491162&partnerID=8YFLogxK

U2 - 10.1007/s10014-015-0227-3

DO - 10.1007/s10014-015-0227-3

M3 - Article

C2 - 26201842

AN - SCOPUS:84945491162

VL - 32

SP - 245

EP - 252

JO - Brain Tumor Pathology

JF - Brain Tumor Pathology

SN - 1433-7398

IS - 4

ER -