Evaluation of calcium alginate gel as electrode material for alternating current iontophoresis of lidocaine using excised rat skin

Tomoko Ebisawa, Atsushi Nakajima, Haruka Haida, Ryo Wakita, Shizuka Ando, Tomohiko Yoshioka, Toshiyuki Ikoma, Junzo Tanaka, Haruhisa Fukayama

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Iontophoresis (IOP) is a noninvasive method of delivering medication transcutaneously through the skin. The electrodes used in this method should tightly fit to rough and irregular surfaces and be biologically safe, easy to handle and prepare, and cost-effective. To satisfy these requirements, calcium alginate gel can be a candidate electrode for IOP. Using calcium alginate gel electrodes, we examined whether lidocaine can be effectively transported across an excised rat skin by squarewave alternating current (AC) application. A squarewave AC with either a 70 % or 80 % duty cycle was continuously applied to 0.5 % calcium alginate gel electrodes containing 10 % lidocaine at 10 V and 1 kHz for 60 min. Lidocaine concentration was measured using a spectrophotometer and the temperature of the gel was determined. The lidocaine concentrations for AC-IOP at the 70 % and 80 % duty cycles were significantly higher than that without AC-IOP. Furthermore, the group with the 80 % duty cycle showed higher lidocaine concentrations than the group with the 70 % duty cycle. The temperatures of all the groups were lower than 28 °C throughout the procedure. In conclusion, the calcium alginate gel can be used as a possible matrix for IOP electrodes.

Original languageEnglish
Pages (from-to)41-48
Number of pages8
JournalJournal of Medical and Dental Sciences
Volume61
Issue number2
Publication statusPublished - 2014
Externally publishedYes

Keywords

  • Alternating current (AC)
  • Calcium alginate gel
  • Drug delivery system (DDS)
  • Electrode
  • Iontophoresis (IOP)

ASJC Scopus subject areas

  • Dentistry(all)

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  • Cite this

    Ebisawa, T., Nakajima, A., Haida, H., Wakita, R., Ando, S., Yoshioka, T., Ikoma, T., Tanaka, J., & Fukayama, H. (2014). Evaluation of calcium alginate gel as electrode material for alternating current iontophoresis of lidocaine using excised rat skin. Journal of Medical and Dental Sciences, 61(2), 41-48.