Evaluation of a urinary multi-parameter biomarker set for oxidative stress in children, adolescents and young adults

Satoshi Tamura, Hirokazu Tsukahara, Masaki Ueno, Masayuki Maeda, Hisako Kawakami, Kyouichi Sekine, Mitsufumi Mayumi

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The involvement of reactive oxygen species (ROS) and oxidative stress in pediatric diseases is an important concern, but oxidative stress status in healthy young subjects and appropriate methods for its measurement remain unclear. This study evaluated a comprehensive set of urinary biomarkers for oxidative stress in healthy children, adolescents and young adults. Results show that urinary excretion of acrolein-lysine, 8-hydroxy-2′-deoxyguanosine (8-OHdG), nitrite/nitrate and pentosidine were highest in the youngest subjects and decreased to constant levels by early adolescence. Urinary acrolein-lysine, 8-OHdG, nitrite/nitrate and pentosidine showed significant inverse correlations with age, but pyrraline did not change significantly with age. No significant differences in biomarkers were apparent between males and females. Younger subjects grow rapidly and sustain immune activation, and are probably exposed to high concentrations of ROS and nitric oxide. Consequently, they are more vulnerable to oxidation of lipids, proteins, DNA and carbohydrates. Normal reported values in this study are a basis for future studies of disease mechanisms involving oxidative stress and for future trials using antioxidant therapies for oxidative stress-related diseases in the pediatric field.

Original languageEnglish
Pages (from-to)1198-1205
Number of pages8
JournalFree Radical Research
Volume40
Issue number11
DOIs
Publication statusPublished - Nov 2006
Externally publishedYes

Fingerprint

Oxidative stress
Biomarkers
Young Adult
Oxidative Stress
Acrolein
Pediatrics
Nitrites
Nitrates
Lysine
Reactive Oxygen Species
Healthy Volunteers
Nitric Oxide
Reference Values
Antioxidants
Chemical activation
Carbohydrates
Lipids
Oxidation
DNA
Proteins

Keywords

  • Biomarkers
  • Oxidative stress
  • Urine
  • Young subjects

ASJC Scopus subject areas

  • Biochemistry

Cite this

Evaluation of a urinary multi-parameter biomarker set for oxidative stress in children, adolescents and young adults. / Tamura, Satoshi; Tsukahara, Hirokazu; Ueno, Masaki; Maeda, Masayuki; Kawakami, Hisako; Sekine, Kyouichi; Mayumi, Mitsufumi.

In: Free Radical Research, Vol. 40, No. 11, 11.2006, p. 1198-1205.

Research output: Contribution to journalArticle

Tamura, Satoshi ; Tsukahara, Hirokazu ; Ueno, Masaki ; Maeda, Masayuki ; Kawakami, Hisako ; Sekine, Kyouichi ; Mayumi, Mitsufumi. / Evaluation of a urinary multi-parameter biomarker set for oxidative stress in children, adolescents and young adults. In: Free Radical Research. 2006 ; Vol. 40, No. 11. pp. 1198-1205.
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