Evaluating the performance of a hybrid artificial liver support system with a recoverable hepatic failure rat model

Hiroyuki Ijima, Ayako Noguchi, Takeyuki Katsuno, Tsutomu Ono, Kohji Nakazawa, Kazumori Funatsu, Koei Kawakami

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

To evaluate the performance of an artificial liver, we created a recoverable hepatic failure rat model. This involves a 30-60 minute warm ischemia, via clamping, of one-third of the liver with a partial (two-thirds) hepatectomy. Variations on this method provide for the possibility of several modes of hepatic failure. Survival time of the rats was prolonged (35%) by applying our hybrid artificial liver. However, the extracorporeal circulation is a considerable burden to the rat. Therefore, we need to apply the hybrid artificial liver intermittently and repeatedly.

Original languageEnglish
Pages (from-to)344-349
Number of pages6
JournalAnnals of the New York Academy of Sciences
Volume944
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Artificial Liver
Liver Failure
Liver
Rats
Warm Ischemia
Extracorporeal Circulation
Hepatectomy
Constriction
Artificial
Rat

Keywords

  • Hepatic failure
  • Hybrid artificial liver
  • Rat model
  • Support system

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Evaluating the performance of a hybrid artificial liver support system with a recoverable hepatic failure rat model. / Ijima, Hiroyuki; Noguchi, Ayako; Katsuno, Takeyuki; Ono, Tsutomu; Nakazawa, Kohji; Funatsu, Kazumori; Kawakami, Koei.

In: Annals of the New York Academy of Sciences, Vol. 944, 2001, p. 344-349.

Research output: Contribution to journalArticle

Ijima, Hiroyuki ; Noguchi, Ayako ; Katsuno, Takeyuki ; Ono, Tsutomu ; Nakazawa, Kohji ; Funatsu, Kazumori ; Kawakami, Koei. / Evaluating the performance of a hybrid artificial liver support system with a recoverable hepatic failure rat model. In: Annals of the New York Academy of Sciences. 2001 ; Vol. 944. pp. 344-349.
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