Evaluating the performance of a hybrid artificial liver support system with a recoverable hepatic failure rat model

Hiroyuki Ijima, Ayako Noguchi, Takeyuki Katsuno, Tsutomu Ono, Kohji Nakazawa, Kazumori Funatsu, Koei Kawakami

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

To evaluate the performance of an artificial liver, we created a recoverable hepatic failure rat model. This involves a 30-60 minute warm ischemia, via clamping, of one-third of the liver with a partial (two-thirds) hepatectomy. Variations on this method provide for the possibility of several modes of hepatic failure. Survival time of the rats was prolonged (35%) by applying our hybrid artificial liver. However, the extracorporeal circulation is a considerable burden to the rat. Therefore, we need to apply the hybrid artificial liver intermittently and repeatedly.

Original languageEnglish
Pages (from-to)344-349
Number of pages6
JournalAnnals of the New York Academy of Sciences
Volume944
Publication statusPublished - 2001
Externally publishedYes

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Keywords

  • Hepatic failure
  • Hybrid artificial liver
  • Rat model
  • Support system

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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