Eudistomidins H-K, new β-carboline alkaloids from the Okinawan marine tunicate Eudistoma glaucus

Teppei Suzuki, Takaaki Kubota, Jun'Ichi Kobayashi

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

Four new β-carboline alkaloids, eudistomidins H-K (1-4), were isolated from an Okinawan marine tunicate Eudistoma glaucus and the structures of 1-4 were elucidated on the basis of spectroscopic data. Eudistomidins H (1) and I (2) were new β-carboline alkaloids possessing a unique fused-tetracyclic ring system consisting of a tetrahydro β-carboline ring and a hexahydropyrimidine ring. Eudistomidin J (3) showed relatively potent cytotoxicity against murine leukemia cells P388 and L1210, and human epidermoid carcinoma cells KB in vitro.

Original languageEnglish
Pages (from-to)4220-4223
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume21
Issue number14
DOIs
Publication statusPublished - Jul 15 2011
Externally publishedYes

Keywords

  • β-carboline alkaloids
  • Eudistoma glaucus
  • Eudistomidins H-K
  • Marine tunicate

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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