Etiology and clinical implications of microvascular dysfunction in patients with acute myocardial infarction

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20 Citations (Scopus)

Abstract

In patients with acute myocardial infarction (MI), coronary microvasculatures are often damaged irreversibly due to myocardial ischemia and reperfusion, and fl ow to the previously ischemic myocardium is markedly reduced, a phenomenon known as the "no-refl ow phenomenon". Percutaneous coronary intervention (PCI) may accelerate embolization of plaque gruels and microthrombi to the microvessels, which further reduces tissue perfusion. The extent of the no-refl ow zone correlates with infarct size, and it has additional prognostic information. Recent advances in imaging modalities have enabled us to diagnose the no-refl ow phenomenon and to assess the mechanisms of the no-refl ow phenomenon. Pharmacological interventions and catheter-based devices to retrieve embolic materials have been proposed, and some of them are associated with improvement in clinical outcomes. Thus, we should keep in mind that only the achievement of complete microvascular perfusion is associated with better functional and clinical outcomes in patients with acute MI.

Original languageEnglish
Pages (from-to)185-189
Number of pages5
JournalInternational Heart Journal
Volume55
Issue number3
DOIs
Publication statusPublished - 2014

Fingerprint

Microvessels
Perfusion
Myocardial Infarction
Myocardial Reperfusion
Percutaneous Coronary Intervention
Myocardial Ischemia
Myocardium
Catheters
Pharmacology
Equipment and Supplies

Keywords

  • Echocardiography
  • Microcirculation
  • Myocardial ischemia
  • Myocardial perfusion
  • Myocardial viability
  • Prognosis
  • Reperfusion
  • Ventricular function

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Etiology and clinical implications of microvascular dysfunction in patients with acute myocardial infarction",
abstract = "In patients with acute myocardial infarction (MI), coronary microvasculatures are often damaged irreversibly due to myocardial ischemia and reperfusion, and fl ow to the previously ischemic myocardium is markedly reduced, a phenomenon known as the {"}no-refl ow phenomenon{"}. Percutaneous coronary intervention (PCI) may accelerate embolization of plaque gruels and microthrombi to the microvessels, which further reduces tissue perfusion. The extent of the no-refl ow zone correlates with infarct size, and it has additional prognostic information. Recent advances in imaging modalities have enabled us to diagnose the no-refl ow phenomenon and to assess the mechanisms of the no-refl ow phenomenon. Pharmacological interventions and catheter-based devices to retrieve embolic materials have been proposed, and some of them are associated with improvement in clinical outcomes. Thus, we should keep in mind that only the achievement of complete microvascular perfusion is associated with better functional and clinical outcomes in patients with acute MI.",
keywords = "Echocardiography, Microcirculation, Myocardial ischemia, Myocardial perfusion, Myocardial viability, Prognosis, Reperfusion, Ventricular function",
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PY - 2014

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KW - Reperfusion

KW - Ventricular function

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