Ethnicity affects EGFR and KRAS gene alterations of lung adenocarcinoma

Junichi Sou, Shinichi Toyooka, Keitaro Matsuo, Hiromasa Yamamoto, Ignacio I. Wistuba, Stephen Lam, Kwun M. Fong, Adi F. Gazdar, Shinichiro Miyoshi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Mutations or copy number gains (CNGs) of the EGFR and KRAS genes are representative alterations in lung adenocarcinomas that are individually associated with patient characteristics such as ethnicity, smoking status and gender. However, the effects of combinations of these genetic alterations have not been statistically examined. The present study analyzed previously examined lung adenocarcinoma cases in Asian (n=166) and non‑Asian (n=136) individuals in whom all four EGFR and KRAS alterations had been studied. The polynomial logistic regression models were used following adjustment for gender and smoking status, and using patients without any type of EGFR/KRAS alterations as a reference. Between the two ethnic groups, EGFR CNGs (gEGFR) occurred more frequently than EGFR mutations (mEGFR) (46 vs. 38% in Asians; 21 vs. 10% in non‑Asians), whereas KRAS mutations (mKRAS) were more frequent than KRAS CNGs (gKRAS) (13 vs. 7% and 35 vs. 4%, respectively). Additionally, gEGFR and gKRAS occurred significantly more frequently in respective mutant cases, and all EGFR alterations were almost exclusive of all KRAS alterations. The polynomial logistic regression models confirmed that all types of EGFR alterations were significantly more frequent among Asian individuals than among non‑Asian individuals, independent of gender and smoking status (odds ratios, 2.36‑6.67). KRAS alterations occurred less frequently among Asian individuals than among non‑Asian individuals, although a significant difference was not detected. The present study results indicated that the EGFR and KRAS profiles, including mutations and CNGs, differ between Asian and non‑Asian individuals with lung adenocarcinoma, suggesting that ethnicity strongly affects the molecular characteristics of lung adenocarcinoma.

Original languageEnglish
Pages (from-to)1775-1782
Number of pages8
JournalOncology Letters
Volume10
Issue number3
DOIs
Publication statusPublished - Sep 1 2015

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erbB-1 Genes
Logistic Models
Mutation
Smoking
Ethnic Groups
Odds Ratio
Adenocarcinoma of lung

Keywords

  • Copy number gain
  • EGFR
  • Ethnicity
  • KRAS
  • Lung adenocarcinoma
  • Mutation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Ethnicity affects EGFR and KRAS gene alterations of lung adenocarcinoma. / Sou, Junichi; Toyooka, Shinichi; Matsuo, Keitaro; Yamamoto, Hiromasa; Wistuba, Ignacio I.; Lam, Stephen; Fong, Kwun M.; Gazdar, Adi F.; Miyoshi, Shinichiro.

In: Oncology Letters, Vol. 10, No. 3, 01.09.2015, p. 1775-1782.

Research output: Contribution to journalArticle

Sou, J, Toyooka, S, Matsuo, K, Yamamoto, H, Wistuba, II, Lam, S, Fong, KM, Gazdar, AF & Miyoshi, S 2015, 'Ethnicity affects EGFR and KRAS gene alterations of lung adenocarcinoma', Oncology Letters, vol. 10, no. 3, pp. 1775-1782. https://doi.org/10.3892/ol.2015.3414
Sou, Junichi ; Toyooka, Shinichi ; Matsuo, Keitaro ; Yamamoto, Hiromasa ; Wistuba, Ignacio I. ; Lam, Stephen ; Fong, Kwun M. ; Gazdar, Adi F. ; Miyoshi, Shinichiro. / Ethnicity affects EGFR and KRAS gene alterations of lung adenocarcinoma. In: Oncology Letters. 2015 ; Vol. 10, No. 3. pp. 1775-1782.
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