Estrogen and androgen receptors in hepatocellular carcinoma and in noncancerous liver tissue

K. Hamazaki, H. Miura, H. Sakai, S. Sato, M. Yunoki, N. Miichi, T. Noda, M. Mori, K. Orita

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3 Citations (Scopus)

Abstract

We have assayed both estrogen and androgen receptors in hepatocellular carcinomas, in the surrounding noncancerous liver tissue, and in normal liver tissue. Estrogen receptors (ERs) were detected in 5 out of 22 HCC tissues, 14 out of 22 surrounding noncancerous tissues, and in 5 out of 6 normal liver tissues. Androgen receptors (Ars) were detected in 4 out of 21 HCC tissues, in 7 out of 21 surrounding noncancerous tissues, and in 2 out of 5 normal liver tissues. These results suggest that the pathogenesis of some HCC may be dependent on estrogen or androgen. Hence, it may be beneficial to provide hormonal therapy for HCC, especially in cases that show high concentrations of ER and/or AR.

Original languageEnglish
Pages (from-to)1109-1113
Number of pages5
JournalGan no rinsho. Japan journal of cancer clinics
Volume35
Issue number10
Publication statusPublished - Sep 1989

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    Hamazaki, K., Miura, H., Sakai, H., Sato, S., Yunoki, M., Miichi, N., Noda, T., Mori, M., & Orita, K. (1989). Estrogen and androgen receptors in hepatocellular carcinoma and in noncancerous liver tissue. Gan no rinsho. Japan journal of cancer clinics, 35(10), 1109-1113.