Abstract
When the population parameters of drug pharmacokinetics in the human body system are known, the time-course of a certain drug in an individual can generally be estimated by pharmacokinetics. In the present two cases where methamphetamine abusers were suspected to have inflicted mortalities in traffic accidents, the time-elapse or duration immediately after methamphetamine injection to the time when the accidents occurred became points of contention. In each case, we estimated the time-course of blood methamphetamine after the self-administration in the suspects using a 2-compartment pharmacokinetic model with known pharmacokinetic parameters from the literatures. If the injected amount can be determined to a certain extent, it is easy to calculate the average time-elapse after injection by referring to reference values. However, there is considerable individual variability in the elimination rate based on genetic polymorphism and a considerably large error range in the estimated time-elapse results. To minimize estimation errors in such cases, we also analyzed genotype of . CYP2D6, which influenced methamphetamine metabolism. Estimation based on two time-point blood samples would usefully benefit legal authorities in passing ruling sentences in cases involving similar personalities and circumstances as those involved in the present study.
| Original language | English |
|---|---|
| Pages (from-to) | 191-196 |
| Number of pages | 6 |
| Journal | Legal Medicine |
| Volume | 14 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jul 2012 |
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Keywords
- Methamphetamine
- Pharmacokinetic model
- Traffic accident
- Vehicular homicide
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Issues, ethics and legal aspects
Cite this
Estimation of the duration after methamphetamine injection using a pharmacokinetic model in suspects who caused fatal traffic accidents. / Matsubara, Kazuo; Asari, Masaru; Suno, Manabu; Awaya, Toshio; Sugawara, Mitsuru; Omura, Tomohiro; Yamamoto, Joe; Maseda, Chikatoshi; Tasaki, Yoshikazu; Shiono, Hiroshi; Shimizu, Keiko.
In: Legal Medicine, Vol. 14, No. 4, 07.2012, p. 191-196.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Estimation of the duration after methamphetamine injection using a pharmacokinetic model in suspects who caused fatal traffic accidents
AU - Matsubara, Kazuo
AU - Asari, Masaru
AU - Suno, Manabu
AU - Awaya, Toshio
AU - Sugawara, Mitsuru
AU - Omura, Tomohiro
AU - Yamamoto, Joe
AU - Maseda, Chikatoshi
AU - Tasaki, Yoshikazu
AU - Shiono, Hiroshi
AU - Shimizu, Keiko
PY - 2012/7
Y1 - 2012/7
N2 - When the population parameters of drug pharmacokinetics in the human body system are known, the time-course of a certain drug in an individual can generally be estimated by pharmacokinetics. In the present two cases where methamphetamine abusers were suspected to have inflicted mortalities in traffic accidents, the time-elapse or duration immediately after methamphetamine injection to the time when the accidents occurred became points of contention. In each case, we estimated the time-course of blood methamphetamine after the self-administration in the suspects using a 2-compartment pharmacokinetic model with known pharmacokinetic parameters from the literatures. If the injected amount can be determined to a certain extent, it is easy to calculate the average time-elapse after injection by referring to reference values. However, there is considerable individual variability in the elimination rate based on genetic polymorphism and a considerably large error range in the estimated time-elapse results. To minimize estimation errors in such cases, we also analyzed genotype of . CYP2D6, which influenced methamphetamine metabolism. Estimation based on two time-point blood samples would usefully benefit legal authorities in passing ruling sentences in cases involving similar personalities and circumstances as those involved in the present study.
AB - When the population parameters of drug pharmacokinetics in the human body system are known, the time-course of a certain drug in an individual can generally be estimated by pharmacokinetics. In the present two cases where methamphetamine abusers were suspected to have inflicted mortalities in traffic accidents, the time-elapse or duration immediately after methamphetamine injection to the time when the accidents occurred became points of contention. In each case, we estimated the time-course of blood methamphetamine after the self-administration in the suspects using a 2-compartment pharmacokinetic model with known pharmacokinetic parameters from the literatures. If the injected amount can be determined to a certain extent, it is easy to calculate the average time-elapse after injection by referring to reference values. However, there is considerable individual variability in the elimination rate based on genetic polymorphism and a considerably large error range in the estimated time-elapse results. To minimize estimation errors in such cases, we also analyzed genotype of . CYP2D6, which influenced methamphetamine metabolism. Estimation based on two time-point blood samples would usefully benefit legal authorities in passing ruling sentences in cases involving similar personalities and circumstances as those involved in the present study.
KW - Methamphetamine
KW - Pharmacokinetic model
KW - Traffic accident
KW - Vehicular homicide
UR - http://www.scopus.com/inward/record.url?scp=84861344571&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84861344571&partnerID=8YFLogxK
U2 - 10.1016/j.legalmed.2012.01.013
DO - 10.1016/j.legalmed.2012.01.013
M3 - Article
VL - 14
SP - 191
EP - 196
JO - Legal Medicine
JF - Legal Medicine
SN - 1344-6223
IS - 4
ER -