Estimation of the duration after methamphetamine injection using a pharmacokinetic model in suspects who caused fatal traffic accidents

Kazuo Matsubara, Masaru Asari, Manabu Suno, Toshio Awaya, Mitsuru Sugawara, Tomohiro Omura, Joe Yamamoto, Chikatoshi Maseda, Yoshikazu Tasaki, Hiroshi Shiono, Keiko Shimizu

Research output: Contribution to journalArticle

Abstract

When the population parameters of drug pharmacokinetics in the human body system are known, the time-course of a certain drug in an individual can generally be estimated by pharmacokinetics. In the present two cases where methamphetamine abusers were suspected to have inflicted mortalities in traffic accidents, the time-elapse or duration immediately after methamphetamine injection to the time when the accidents occurred became points of contention. In each case, we estimated the time-course of blood methamphetamine after the self-administration in the suspects using a 2-compartment pharmacokinetic model with known pharmacokinetic parameters from the literatures. If the injected amount can be determined to a certain extent, it is easy to calculate the average time-elapse after injection by referring to reference values. However, there is considerable individual variability in the elimination rate based on genetic polymorphism and a considerably large error range in the estimated time-elapse results. To minimize estimation errors in such cases, we also analyzed genotype of . CYP2D6, which influenced methamphetamine metabolism. Estimation based on two time-point blood samples would usefully benefit legal authorities in passing ruling sentences in cases involving similar personalities and circumstances as those involved in the present study.

Original languageEnglish
Pages (from-to)191-196
Number of pages6
JournalLegal Medicine
Volume14
Issue number4
DOIs
Publication statusPublished - Jul 2012

Fingerprint

Methamphetamine
Traffic Accidents
Pharmacokinetics
Injections
Cytochrome P-450 CYP2D6
Self Administration
Genetic Polymorphisms
Human Body
Pharmaceutical Preparations
Accidents
Personality
Reference Values
Genotype
Mortality
Population

Keywords

  • Methamphetamine
  • Pharmacokinetic model
  • Traffic accident
  • Vehicular homicide

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Issues, ethics and legal aspects

Cite this

Estimation of the duration after methamphetamine injection using a pharmacokinetic model in suspects who caused fatal traffic accidents. / Matsubara, Kazuo; Asari, Masaru; Suno, Manabu; Awaya, Toshio; Sugawara, Mitsuru; Omura, Tomohiro; Yamamoto, Joe; Maseda, Chikatoshi; Tasaki, Yoshikazu; Shiono, Hiroshi; Shimizu, Keiko.

In: Legal Medicine, Vol. 14, No. 4, 07.2012, p. 191-196.

Research output: Contribution to journalArticle

Matsubara, K, Asari, M, Suno, M, Awaya, T, Sugawara, M, Omura, T, Yamamoto, J, Maseda, C, Tasaki, Y, Shiono, H & Shimizu, K 2012, 'Estimation of the duration after methamphetamine injection using a pharmacokinetic model in suspects who caused fatal traffic accidents', Legal Medicine, vol. 14, no. 4, pp. 191-196. https://doi.org/10.1016/j.legalmed.2012.01.013
Matsubara, Kazuo ; Asari, Masaru ; Suno, Manabu ; Awaya, Toshio ; Sugawara, Mitsuru ; Omura, Tomohiro ; Yamamoto, Joe ; Maseda, Chikatoshi ; Tasaki, Yoshikazu ; Shiono, Hiroshi ; Shimizu, Keiko. / Estimation of the duration after methamphetamine injection using a pharmacokinetic model in suspects who caused fatal traffic accidents. In: Legal Medicine. 2012 ; Vol. 14, No. 4. pp. 191-196.
@article{922c5ad6330f47c4aedaf1644b6bb9d0,
title = "Estimation of the duration after methamphetamine injection using a pharmacokinetic model in suspects who caused fatal traffic accidents",
abstract = "When the population parameters of drug pharmacokinetics in the human body system are known, the time-course of a certain drug in an individual can generally be estimated by pharmacokinetics. In the present two cases where methamphetamine abusers were suspected to have inflicted mortalities in traffic accidents, the time-elapse or duration immediately after methamphetamine injection to the time when the accidents occurred became points of contention. In each case, we estimated the time-course of blood methamphetamine after the self-administration in the suspects using a 2-compartment pharmacokinetic model with known pharmacokinetic parameters from the literatures. If the injected amount can be determined to a certain extent, it is easy to calculate the average time-elapse after injection by referring to reference values. However, there is considerable individual variability in the elimination rate based on genetic polymorphism and a considerably large error range in the estimated time-elapse results. To minimize estimation errors in such cases, we also analyzed genotype of . CYP2D6, which influenced methamphetamine metabolism. Estimation based on two time-point blood samples would usefully benefit legal authorities in passing ruling sentences in cases involving similar personalities and circumstances as those involved in the present study.",
keywords = "Methamphetamine, Pharmacokinetic model, Traffic accident, Vehicular homicide",
author = "Kazuo Matsubara and Masaru Asari and Manabu Suno and Toshio Awaya and Mitsuru Sugawara and Tomohiro Omura and Joe Yamamoto and Chikatoshi Maseda and Yoshikazu Tasaki and Hiroshi Shiono and Keiko Shimizu",
year = "2012",
month = "7",
doi = "10.1016/j.legalmed.2012.01.013",
language = "English",
volume = "14",
pages = "191--196",
journal = "Legal Medicine",
issn = "1344-6223",
publisher = "Elsevier",
number = "4",

}

TY - JOUR

T1 - Estimation of the duration after methamphetamine injection using a pharmacokinetic model in suspects who caused fatal traffic accidents

AU - Matsubara, Kazuo

AU - Asari, Masaru

AU - Suno, Manabu

AU - Awaya, Toshio

AU - Sugawara, Mitsuru

AU - Omura, Tomohiro

AU - Yamamoto, Joe

AU - Maseda, Chikatoshi

AU - Tasaki, Yoshikazu

AU - Shiono, Hiroshi

AU - Shimizu, Keiko

PY - 2012/7

Y1 - 2012/7

N2 - When the population parameters of drug pharmacokinetics in the human body system are known, the time-course of a certain drug in an individual can generally be estimated by pharmacokinetics. In the present two cases where methamphetamine abusers were suspected to have inflicted mortalities in traffic accidents, the time-elapse or duration immediately after methamphetamine injection to the time when the accidents occurred became points of contention. In each case, we estimated the time-course of blood methamphetamine after the self-administration in the suspects using a 2-compartment pharmacokinetic model with known pharmacokinetic parameters from the literatures. If the injected amount can be determined to a certain extent, it is easy to calculate the average time-elapse after injection by referring to reference values. However, there is considerable individual variability in the elimination rate based on genetic polymorphism and a considerably large error range in the estimated time-elapse results. To minimize estimation errors in such cases, we also analyzed genotype of . CYP2D6, which influenced methamphetamine metabolism. Estimation based on two time-point blood samples would usefully benefit legal authorities in passing ruling sentences in cases involving similar personalities and circumstances as those involved in the present study.

AB - When the population parameters of drug pharmacokinetics in the human body system are known, the time-course of a certain drug in an individual can generally be estimated by pharmacokinetics. In the present two cases where methamphetamine abusers were suspected to have inflicted mortalities in traffic accidents, the time-elapse or duration immediately after methamphetamine injection to the time when the accidents occurred became points of contention. In each case, we estimated the time-course of blood methamphetamine after the self-administration in the suspects using a 2-compartment pharmacokinetic model with known pharmacokinetic parameters from the literatures. If the injected amount can be determined to a certain extent, it is easy to calculate the average time-elapse after injection by referring to reference values. However, there is considerable individual variability in the elimination rate based on genetic polymorphism and a considerably large error range in the estimated time-elapse results. To minimize estimation errors in such cases, we also analyzed genotype of . CYP2D6, which influenced methamphetamine metabolism. Estimation based on two time-point blood samples would usefully benefit legal authorities in passing ruling sentences in cases involving similar personalities and circumstances as those involved in the present study.

KW - Methamphetamine

KW - Pharmacokinetic model

KW - Traffic accident

KW - Vehicular homicide

UR - http://www.scopus.com/inward/record.url?scp=84861344571&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861344571&partnerID=8YFLogxK

U2 - 10.1016/j.legalmed.2012.01.013

DO - 10.1016/j.legalmed.2012.01.013

M3 - Article

VL - 14

SP - 191

EP - 196

JO - Legal Medicine

JF - Legal Medicine

SN - 1344-6223

IS - 4

ER -