Abstract
To improve the results of hepatectomy in cirrhotic patients, the likely reserve function of the liver was evaluated before surgery. Asialoglycoprotein receptor (ASGP-R) is a hepatic cell surface receptor specific for galactose-terminated glycoproteins. Technetium-99m-diethylene triamine pentaacetic acid-galactosyl human serum albumin (99mTc-GSA) is a newly developed analog ligand to ASPG-R. The probable functional reserve of the remnant liver after hepatectomy was estimated preoperatively as the hepatic binding protein (HBP) concentration specific for ASGP-R on the hepatocellular membrane of the remnant liver. This estimate was based on the effective liver volume rate, obtained by the uptake of99mTc-GSA. In all, 3 normal volunteers, 3 patients with chronic hepatitis (CH), 9 patients with liver cirrhosis (LC), 2 patients with hepatic cystadenoma, 3 patients with hepatocellular carcinoma (HCC) associated with CH, and 21 HCC patients with LC were studied. The mean value ±SD obtained for HBP in normal volunteers (three cases) and in patients with mild (four cases), moderate (two cases), and severe liver damage (five cases) were 0.74±0.03 μM, 0.43±0.042 μM, 0.31±0.05 μM, and 0.20±0.05 μM, respectively. Most of the cases in which the preoperative HBP of the remnant liver was above 0.22 μM had a good postoperative course irrespective of the type of hepatectomy. On the other hand, in subjects with a remnant liver HBP of between 0.22 and 0.11 μM, postoperative severe liver dysfunction occurred in about 50% of cases. In all cases with a remnant liver HBP below 0.1 μM, the prognosis was very poor, indicating that hepatectomy should be avoided. The HBP concentration detected by the99mTc-GSA study is a very sensitive indicator of changes in the hepatic functional reserve, and the HBP value for the functional reserve of the remnant liver is extremely useful for estimating the liver function before and after hepatectomy.
| Original language | English |
|---|---|
| Journal | Cancer Chemotherapy and Pharmacology |
| Volume | 33 |
| Issue number | 1 Supplement |
| DOIs | |
| Publication status | Published - Jan 1994 |
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ASJC Scopus subject areas
- Pharmacology
- Oncology
- Cancer Research
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Estimation of remnant liver function before hepatectomy by means of technetium-99m-diethylenetriamine-pentaacetic acid galactosyl human albumin. / Yumoto, Yasuhiro; Umeda, Masakichi; Ohshima, Kanji; Ogawa, Hiromichi; Kurokawa, Tatsuo; Kajitani, Motonao; Yumoto, Eiichiro; Hanafusa, Tadashi; Tsuboi, Hajime; Higashi, Toshihiro; Mitani, Tsuyoshi; Tsuji, Takao.
In: Cancer Chemotherapy and Pharmacology, Vol. 33, No. 1 Supplement, 01.1994.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Estimation of remnant liver function before hepatectomy by means of technetium-99m-diethylenetriamine-pentaacetic acid galactosyl human albumin
AU - Yumoto, Yasuhiro
AU - Umeda, Masakichi
AU - Ohshima, Kanji
AU - Ogawa, Hiromichi
AU - Kurokawa, Tatsuo
AU - Kajitani, Motonao
AU - Yumoto, Eiichiro
AU - Hanafusa, Tadashi
AU - Tsuboi, Hajime
AU - Higashi, Toshihiro
AU - Mitani, Tsuyoshi
AU - Tsuji, Takao
PY - 1994/1
Y1 - 1994/1
N2 - To improve the results of hepatectomy in cirrhotic patients, the likely reserve function of the liver was evaluated before surgery. Asialoglycoprotein receptor (ASGP-R) is a hepatic cell surface receptor specific for galactose-terminated glycoproteins. Technetium-99m-diethylene triamine pentaacetic acid-galactosyl human serum albumin (99mTc-GSA) is a newly developed analog ligand to ASPG-R. The probable functional reserve of the remnant liver after hepatectomy was estimated preoperatively as the hepatic binding protein (HBP) concentration specific for ASGP-R on the hepatocellular membrane of the remnant liver. This estimate was based on the effective liver volume rate, obtained by the uptake of99mTc-GSA. In all, 3 normal volunteers, 3 patients with chronic hepatitis (CH), 9 patients with liver cirrhosis (LC), 2 patients with hepatic cystadenoma, 3 patients with hepatocellular carcinoma (HCC) associated with CH, and 21 HCC patients with LC were studied. The mean value ±SD obtained for HBP in normal volunteers (three cases) and in patients with mild (four cases), moderate (two cases), and severe liver damage (five cases) were 0.74±0.03 μM, 0.43±0.042 μM, 0.31±0.05 μM, and 0.20±0.05 μM, respectively. Most of the cases in which the preoperative HBP of the remnant liver was above 0.22 μM had a good postoperative course irrespective of the type of hepatectomy. On the other hand, in subjects with a remnant liver HBP of between 0.22 and 0.11 μM, postoperative severe liver dysfunction occurred in about 50% of cases. In all cases with a remnant liver HBP below 0.1 μM, the prognosis was very poor, indicating that hepatectomy should be avoided. The HBP concentration detected by the99mTc-GSA study is a very sensitive indicator of changes in the hepatic functional reserve, and the HBP value for the functional reserve of the remnant liver is extremely useful for estimating the liver function before and after hepatectomy.
AB - To improve the results of hepatectomy in cirrhotic patients, the likely reserve function of the liver was evaluated before surgery. Asialoglycoprotein receptor (ASGP-R) is a hepatic cell surface receptor specific for galactose-terminated glycoproteins. Technetium-99m-diethylene triamine pentaacetic acid-galactosyl human serum albumin (99mTc-GSA) is a newly developed analog ligand to ASPG-R. The probable functional reserve of the remnant liver after hepatectomy was estimated preoperatively as the hepatic binding protein (HBP) concentration specific for ASGP-R on the hepatocellular membrane of the remnant liver. This estimate was based on the effective liver volume rate, obtained by the uptake of99mTc-GSA. In all, 3 normal volunteers, 3 patients with chronic hepatitis (CH), 9 patients with liver cirrhosis (LC), 2 patients with hepatic cystadenoma, 3 patients with hepatocellular carcinoma (HCC) associated with CH, and 21 HCC patients with LC were studied. The mean value ±SD obtained for HBP in normal volunteers (three cases) and in patients with mild (four cases), moderate (two cases), and severe liver damage (five cases) were 0.74±0.03 μM, 0.43±0.042 μM, 0.31±0.05 μM, and 0.20±0.05 μM, respectively. Most of the cases in which the preoperative HBP of the remnant liver was above 0.22 μM had a good postoperative course irrespective of the type of hepatectomy. On the other hand, in subjects with a remnant liver HBP of between 0.22 and 0.11 μM, postoperative severe liver dysfunction occurred in about 50% of cases. In all cases with a remnant liver HBP below 0.1 μM, the prognosis was very poor, indicating that hepatectomy should be avoided. The HBP concentration detected by the99mTc-GSA study is a very sensitive indicator of changes in the hepatic functional reserve, and the HBP value for the functional reserve of the remnant liver is extremely useful for estimating the liver function before and after hepatectomy.
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UR - http://www.scopus.com/inward/citedby.url?scp=0028299929&partnerID=8YFLogxK
U2 - 10.1007/BF00686659
DO - 10.1007/BF00686659
M3 - Article
VL - 33
JO - Cancer Chemotherapy and Pharmacology
JF - Cancer Chemotherapy and Pharmacology
SN - 0344-5704
IS - 1 Supplement
ER -