Estimation of remnant liver function before hepatectomy by means of technetium-99m-diethylenetriamine-pentaacetic acid galactosyl human albumin

Yasuhiro Yumoto, Masakichi Umeda, Kanji Ohshima, Hiromichi Ogawa, Tatsuo Kurokawa, Motonao Kajitani, Eiichiro Yumoto, Tadashi Hanafusa, Hajime Tsuboi, Toshihiro Higashi, Tsuyoshi Mitani, Takao Tsuji

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Abstract

To improve the results of hepatectomy in cirrhotic patients, the likely reserve function of the liver was evaluated before surgery. Asialoglycoprotein receptor (ASGP-R) is a hepatic cell surface receptor specific for galactose-terminated glycoproteins. Technetium-99m-diethylene triamine pentaacetic acid-galactosyl human serum albumin (99mTc-GSA) is a newly developed analog ligand to ASPG-R. The probable functional reserve of the remnant liver after hepatectomy was estimated preoperatively as the hepatic binding protein (HBP) concentration specific for ASGP-R on the hepatocellular membrane of the remnant liver. This estimate was based on the effective liver volume rate, obtained by the uptake of99mTc-GSA. In all, 3 normal volunteers, 3 patients with chronic hepatitis (CH), 9 patients with liver cirrhosis (LC), 2 patients with hepatic cystadenoma, 3 patients with hepatocellular carcinoma (HCC) associated with CH, and 21 HCC patients with LC were studied. The mean value ±SD obtained for HBP in normal volunteers (three cases) and in patients with mild (four cases), moderate (two cases), and severe liver damage (five cases) were 0.74±0.03 μM, 0.43±0.042 μM, 0.31±0.05 μM, and 0.20±0.05 μM, respectively. Most of the cases in which the preoperative HBP of the remnant liver was above 0.22 μM had a good postoperative course irrespective of the type of hepatectomy. On the other hand, in subjects with a remnant liver HBP of between 0.22 and 0.11 μM, postoperative severe liver dysfunction occurred in about 50% of cases. In all cases with a remnant liver HBP below 0.1 μM, the prognosis was very poor, indicating that hepatectomy should be avoided. The HBP concentration detected by the99mTc-GSA study is a very sensitive indicator of changes in the hepatic functional reserve, and the HBP value for the functional reserve of the remnant liver is extremely useful for estimating the liver function before and after hepatectomy.

Original languageEnglish
JournalCancer Chemotherapy and Pharmacology
Volume33
Issue number1 Supplement
DOIs
Publication statusPublished - Jan 1994

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Technetium Tc 99m Pentetate
Pentetic Acid
Technetium
Hepatectomy
Liver
Albumins
Asialoglycoprotein Receptor
Chronic Hepatitis
Liver Cirrhosis
Hepatocellular Carcinoma
Healthy Volunteers
Cystadenoma
Cell Surface Receptors
hepatic sialoglycoprotein receptor
Galactose
Serum Albumin

ASJC Scopus subject areas

  • Pharmacology
  • Oncology
  • Cancer Research

Cite this

Estimation of remnant liver function before hepatectomy by means of technetium-99m-diethylenetriamine-pentaacetic acid galactosyl human albumin. / Yumoto, Yasuhiro; Umeda, Masakichi; Ohshima, Kanji; Ogawa, Hiromichi; Kurokawa, Tatsuo; Kajitani, Motonao; Yumoto, Eiichiro; Hanafusa, Tadashi; Tsuboi, Hajime; Higashi, Toshihiro; Mitani, Tsuyoshi; Tsuji, Takao.

In: Cancer Chemotherapy and Pharmacology, Vol. 33, No. 1 Supplement, 01.1994.

Research output: Contribution to journalArticle

Yumoto, Y, Umeda, M, Ohshima, K, Ogawa, H, Kurokawa, T, Kajitani, M, Yumoto, E, Hanafusa, T, Tsuboi, H, Higashi, T, Mitani, T & Tsuji, T 1994, 'Estimation of remnant liver function before hepatectomy by means of technetium-99m-diethylenetriamine-pentaacetic acid galactosyl human albumin', Cancer Chemotherapy and Pharmacology, vol. 33, no. 1 Supplement. https://doi.org/10.1007/BF00686659
Yumoto, Yasuhiro ; Umeda, Masakichi ; Ohshima, Kanji ; Ogawa, Hiromichi ; Kurokawa, Tatsuo ; Kajitani, Motonao ; Yumoto, Eiichiro ; Hanafusa, Tadashi ; Tsuboi, Hajime ; Higashi, Toshihiro ; Mitani, Tsuyoshi ; Tsuji, Takao. / Estimation of remnant liver function before hepatectomy by means of technetium-99m-diethylenetriamine-pentaacetic acid galactosyl human albumin. In: Cancer Chemotherapy and Pharmacology. 1994 ; Vol. 33, No. 1 Supplement.
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abstract = "To improve the results of hepatectomy in cirrhotic patients, the likely reserve function of the liver was evaluated before surgery. Asialoglycoprotein receptor (ASGP-R) is a hepatic cell surface receptor specific for galactose-terminated glycoproteins. Technetium-99m-diethylene triamine pentaacetic acid-galactosyl human serum albumin (99mTc-GSA) is a newly developed analog ligand to ASPG-R. The probable functional reserve of the remnant liver after hepatectomy was estimated preoperatively as the hepatic binding protein (HBP) concentration specific for ASGP-R on the hepatocellular membrane of the remnant liver. This estimate was based on the effective liver volume rate, obtained by the uptake of99mTc-GSA. In all, 3 normal volunteers, 3 patients with chronic hepatitis (CH), 9 patients with liver cirrhosis (LC), 2 patients with hepatic cystadenoma, 3 patients with hepatocellular carcinoma (HCC) associated with CH, and 21 HCC patients with LC were studied. The mean value ±SD obtained for HBP in normal volunteers (three cases) and in patients with mild (four cases), moderate (two cases), and severe liver damage (five cases) were 0.74±0.03 μM, 0.43±0.042 μM, 0.31±0.05 μM, and 0.20±0.05 μM, respectively. Most of the cases in which the preoperative HBP of the remnant liver was above 0.22 μM had a good postoperative course irrespective of the type of hepatectomy. On the other hand, in subjects with a remnant liver HBP of between 0.22 and 0.11 μM, postoperative severe liver dysfunction occurred in about 50{\%} of cases. In all cases with a remnant liver HBP below 0.1 μM, the prognosis was very poor, indicating that hepatectomy should be avoided. The HBP concentration detected by the99mTc-GSA study is a very sensitive indicator of changes in the hepatic functional reserve, and the HBP value for the functional reserve of the remnant liver is extremely useful for estimating the liver function before and after hepatectomy.",
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AU - Umeda, Masakichi

AU - Ohshima, Kanji

AU - Ogawa, Hiromichi

AU - Kurokawa, Tatsuo

AU - Kajitani, Motonao

AU - Yumoto, Eiichiro

AU - Hanafusa, Tadashi

AU - Tsuboi, Hajime

AU - Higashi, Toshihiro

AU - Mitani, Tsuyoshi

AU - Tsuji, Takao

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N2 - To improve the results of hepatectomy in cirrhotic patients, the likely reserve function of the liver was evaluated before surgery. Asialoglycoprotein receptor (ASGP-R) is a hepatic cell surface receptor specific for galactose-terminated glycoproteins. Technetium-99m-diethylene triamine pentaacetic acid-galactosyl human serum albumin (99mTc-GSA) is a newly developed analog ligand to ASPG-R. The probable functional reserve of the remnant liver after hepatectomy was estimated preoperatively as the hepatic binding protein (HBP) concentration specific for ASGP-R on the hepatocellular membrane of the remnant liver. This estimate was based on the effective liver volume rate, obtained by the uptake of99mTc-GSA. In all, 3 normal volunteers, 3 patients with chronic hepatitis (CH), 9 patients with liver cirrhosis (LC), 2 patients with hepatic cystadenoma, 3 patients with hepatocellular carcinoma (HCC) associated with CH, and 21 HCC patients with LC were studied. The mean value ±SD obtained for HBP in normal volunteers (three cases) and in patients with mild (four cases), moderate (two cases), and severe liver damage (five cases) were 0.74±0.03 μM, 0.43±0.042 μM, 0.31±0.05 μM, and 0.20±0.05 μM, respectively. Most of the cases in which the preoperative HBP of the remnant liver was above 0.22 μM had a good postoperative course irrespective of the type of hepatectomy. On the other hand, in subjects with a remnant liver HBP of between 0.22 and 0.11 μM, postoperative severe liver dysfunction occurred in about 50% of cases. In all cases with a remnant liver HBP below 0.1 μM, the prognosis was very poor, indicating that hepatectomy should be avoided. The HBP concentration detected by the99mTc-GSA study is a very sensitive indicator of changes in the hepatic functional reserve, and the HBP value for the functional reserve of the remnant liver is extremely useful for estimating the liver function before and after hepatectomy.

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