Estimation of integral value of input function for the quantification of cerebral blood flow with 123I-IMP using one-point arterial blood sampling

H. Fujioka, K. Murase, T. Inoue, Y. Ishimaru, A. Akamune, Y. Yamamoto, S. Tanada, J. Ikezoe

Research output: Contribution to journalArticle

Abstract

Cerebral blood flow (CBF) has been measured using a microsphere model with octanol-extracted radioactivity counts (integral value of input function). We developed a new method estimating the integral value of input function. First, we fitted the whole brain time-activity curves early after intravenous injection of N-isopropyl-p-[123I]iodoamphetamine (123I-IMP) by the least-squares method. Second, we differentiated this equation. Third, we calibrated it using octanol-extracted radioactivity counts of the arterial blood sampled at 5 min. Finally, we integrated it. A significant correlation was found between the integral values obtained using a new method and those obtained using the continuous arterial blood sampling data (y = 1.048x-1206, r = 0.984). The errors between the CBF values obtained using a new method and those obtained using the 5-min continuous arterial blood sampling was 6.88 +/- 4.78%. Measurement of integral values of the input function using a new method with one-point arterial blood sampling is less invasive and convenient, and is not influenced by cardiopulmonary disease or smoking. Therefore, it would be useful for the routine measurement of CBF.

Original languageEnglish
Pages (from-to)7-14
Number of pages8
JournalKakuigaku
Volume35
Issue number1
Publication statusPublished - Jan 1998
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Estimation of integral value of input function for the quantification of cerebral blood flow with 123I-IMP using one-point arterial blood sampling'. Together they form a unique fingerprint.

  • Cite this

    Fujioka, H., Murase, K., Inoue, T., Ishimaru, Y., Akamune, A., Yamamoto, Y., Tanada, S., & Ikezoe, J. (1998). Estimation of integral value of input function for the quantification of cerebral blood flow with 123I-IMP using one-point arterial blood sampling. Kakuigaku, 35(1), 7-14.