### Abstract

Cerebral blood flow (CBF) has been measured using a microsphere model with octanol-extracted radioactivity counts (integral value of input function). We developed a new method estimating the integral value of input function. First, we fitted the whole brain time-activity curves early after intravenous injection of N-isopropyl-p-[123I]iodoamphetamine (123I-IMP) by the least-squares method. Second, we differentiated this equation. Third, we calibrated it using octanol-extracted radioactivity counts of the arterial blood sampled at 5 min. Finally, we integrated it. A significant correlation was found between the integral values obtained using a new method and those obtained using the continuous arterial blood sampling data (y = 1.048x-1206, r = 0.984). The errors between the CBF values obtained using a new method and those obtained using the 5-min continuous arterial blood sampling was 6.88 +/- 4.78%. Measurement of integral values of the input function using a new method with one-point arterial blood sampling is less invasive and convenient, and is not influenced by cardiopulmonary disease or smoking. Therefore, it would be useful for the routine measurement of CBF.

Original language | English |
---|---|

Pages (from-to) | 7-14 |

Number of pages | 8 |

Journal | Kakuigaku |

Volume | 35 |

Issue number | 1 |

Publication status | Published - Jan 1998 |

Externally published | Yes |

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### ASJC Scopus subject areas

- Radiology Nuclear Medicine and imaging

### Cite this

*Kakuigaku*,

*35*(1), 7-14.

**Estimation of integral value of input function for the quantification of cerebral blood flow with 123I-IMP using one-point arterial blood sampling.** / Fujioka, H.; Murase, K.; Inoue, T.; Ishimaru, Y.; Akamune, A.; Yamamoto, Y.; Tanada, S.; Ikezoe, J.

Research output: Contribution to journal › Article

*Kakuigaku*, vol. 35, no. 1, pp. 7-14.

}

TY - JOUR

T1 - Estimation of integral value of input function for the quantification of cerebral blood flow with 123I-IMP using one-point arterial blood sampling

AU - Fujioka, H.

AU - Murase, K.

AU - Inoue, T.

AU - Ishimaru, Y.

AU - Akamune, A.

AU - Yamamoto, Y.

AU - Tanada, S.

AU - Ikezoe, J.

PY - 1998/1

Y1 - 1998/1

N2 - Cerebral blood flow (CBF) has been measured using a microsphere model with octanol-extracted radioactivity counts (integral value of input function). We developed a new method estimating the integral value of input function. First, we fitted the whole brain time-activity curves early after intravenous injection of N-isopropyl-p-[123I]iodoamphetamine (123I-IMP) by the least-squares method. Second, we differentiated this equation. Third, we calibrated it using octanol-extracted radioactivity counts of the arterial blood sampled at 5 min. Finally, we integrated it. A significant correlation was found between the integral values obtained using a new method and those obtained using the continuous arterial blood sampling data (y = 1.048x-1206, r = 0.984). The errors between the CBF values obtained using a new method and those obtained using the 5-min continuous arterial blood sampling was 6.88 +/- 4.78%. Measurement of integral values of the input function using a new method with one-point arterial blood sampling is less invasive and convenient, and is not influenced by cardiopulmonary disease or smoking. Therefore, it would be useful for the routine measurement of CBF.

AB - Cerebral blood flow (CBF) has been measured using a microsphere model with octanol-extracted radioactivity counts (integral value of input function). We developed a new method estimating the integral value of input function. First, we fitted the whole brain time-activity curves early after intravenous injection of N-isopropyl-p-[123I]iodoamphetamine (123I-IMP) by the least-squares method. Second, we differentiated this equation. Third, we calibrated it using octanol-extracted radioactivity counts of the arterial blood sampled at 5 min. Finally, we integrated it. A significant correlation was found between the integral values obtained using a new method and those obtained using the continuous arterial blood sampling data (y = 1.048x-1206, r = 0.984). The errors between the CBF values obtained using a new method and those obtained using the 5-min continuous arterial blood sampling was 6.88 +/- 4.78%. Measurement of integral values of the input function using a new method with one-point arterial blood sampling is less invasive and convenient, and is not influenced by cardiopulmonary disease or smoking. Therefore, it would be useful for the routine measurement of CBF.

UR - http://www.scopus.com/inward/record.url?scp=0031605911&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031605911&partnerID=8YFLogxK

M3 - Article

VL - 35

SP - 7

EP - 14

JO - Kaku igaku. The Japanese journal of nuclear medicine

JF - Kaku igaku. The Japanese journal of nuclear medicine

SN - 0022-7854

IS - 1

ER -