Estimation of integral of input function for quantification of cerebral blood flow with N-isopropyl-p-[ 123I]iodoamphetamine using one-point venous blood sampling

Hiroyoshi Fujioka, Kenya Murase, Takeshi Inoue, Yoshihiro Ishimaru, Hidemi Ebara, Akihisa Akamune, Yuji Yamamoto, Teruhito Mochizuki, Junpei Ikezoe

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1 Citation (Scopus)

Abstract

The present study was designed to investigate a possibility of substitution of the venous blood radioactivity counts sampled 26 min post injection for the octanol-extracted arterial blood radioactivity counts obtained at 5 min after the injection of N-isopropyl- p[ 123I]iodoamphetamine ( 123I-IMP). Furthermore, we investigated whether the integral of input function can be estimated from the venous blood radioactivity counts sampled 26 min post injection and the whole-brain time- activity curves early after 123I-IMP injection. There was a good correlation between the arterial blood radioactivity counts sampled 5 min post injection (y) and those obtained at 26 min (r=0.902; n=91; y=2.348x- 867.063). There was also a good correlation between the arterial (x) and venous blood radioactivity counts (y) sampled 26 min post injection (r=0.954; n=14; y=0.761x+924.336). The venous blood radioactivity counts sampled at 26 min (x) correlated well with the octanol-extracted arterial blood radioactivity counts sampled at 5 min (y) (r=0.964; n=32; y=0.173x-21.598). There was a good correlation between the integrals of input function obtained from the regression equation obtained above and the whole-brain time-activity curves acquired during 7 min post injection (y) and those obtained by 5-min continuous arterial blood sampling (x) (r=0.965; n=41; y=0.957x+2665.208). These results indicate that this noninvasive and simple method can estimate the integral of input function for quantification of cerebral blood flow using 123I-IMP.

Original languageEnglish
Pages (from-to)801-807
Number of pages7
JournalKakuigaku
Volume36
Issue number8
Publication statusPublished - Dec 8 1999
Externally publishedYes

Keywords

  • Cerebral blood flow
  • Continuous arterial blood sampling
  • I-IMP
  • Input function
  • Venous blood sampling

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Fujioka, H., Murase, K., Inoue, T., Ishimaru, Y., Ebara, H., Akamune, A., Yamamoto, Y., Mochizuki, T., & Ikezoe, J. (1999). Estimation of integral of input function for quantification of cerebral blood flow with N-isopropyl-p-[ 123I]iodoamphetamine using one-point venous blood sampling. Kakuigaku, 36(8), 801-807.