## Abstract

The present study was designed to investigate a possibility of substitution of the venous blood radioactivity counts sampled 26 min post injection for the octanol-extracted arterial blood radioactivity counts obtained at 5 min after the injection of N-isopropyl- p[ ^{123}I]iodoamphetamine ( ^{123}I-IMP). Furthermore, we investigated whether the integral of input function can be estimated from the venous blood radioactivity counts sampled 26 min post injection and the whole-brain time- activity curves early after ^{123}I-IMP injection. There was a good correlation between the arterial blood radioactivity counts sampled 5 min post injection (y) and those obtained at 26 min (r=0.902; n=91; y=2.348x- 867.063). There was also a good correlation between the arterial (x) and venous blood radioactivity counts (y) sampled 26 min post injection (r=0.954; n=14; y=0.761x+924.336). The venous blood radioactivity counts sampled at 26 min (x) correlated well with the octanol-extracted arterial blood radioactivity counts sampled at 5 min (y) (r=0.964; n=32; y=0.173x-21.598). There was a good correlation between the integrals of input function obtained from the regression equation obtained above and the whole-brain time-activity curves acquired during 7 min post injection (y) and those obtained by 5-min continuous arterial blood sampling (x) (r=0.965; n=41; y=0.957x+2665.208). These results indicate that this noninvasive and simple method can estimate the integral of input function for quantification of cerebral blood flow using ^{123}I-IMP.

Original language | English |
---|---|

Pages (from-to) | 801-807 |

Number of pages | 7 |

Journal | Kakuigaku |

Volume | 36 |

Issue number | 8 |

Publication status | Published - Dec 8 1999 |

Externally published | Yes |

## Keywords

- Cerebral blood flow
- Continuous arterial blood sampling
- I-IMP
- Input function
- Venous blood sampling

## ASJC Scopus subject areas

- Radiology Nuclear Medicine and imaging

## Fingerprint

Dive into the research topics of 'Estimation of integral of input function for quantification of cerebral blood flow with N-isopropyl-p-[^{123}I]iodoamphetamine using one-point venous blood sampling'. Together they form a unique fingerprint.